A5051492793- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Global Cancer Incidence and Screening
- Neonatal Respiratory Health Research
- Circular RNAs in diseases
- Multiple and Secondary Primary Cancers
- Cervical Cancer and HPV Research
- Ethnobotanical and Medicinal Plants Studies
- Natural Antidiabetic Agents Studies
- Drug-Induced Hepatotoxicity and Protection
- HER2/EGFR in Cancer Research
- Pregnancy and Medication Impact
- Molecular Biology Techniques and Applications
- Pregnancy and preeclampsia studies
- Diagnosis and treatment of tuberculosis
- Neuroscience of respiration and sleep
- Breast Cancer Treatment Studies
- Prenatal Substance Exposure Effects
- Cancer Risks and Factors
- Cancer Cells and Metastasis
- Child Nutrition and Water Access
- Forensic Toxicology and Drug Analysis
- Congenital Diaphragmatic Hernia Studies
Addis Ababa University
2014-2024
Tikur Anbessa Hospital
2023
Neonatal deaths now account for 47% of all in children younger than 5 years globally. More a third newborn are due to preterm birth complications, which is the leading cause death. Understanding causes and factors contributing neonatal needed identify interventions that will reduce mortality. We aimed establish major mortality infants first 28 days life Ethiopia.We did prospective, cross-sectional, observational study five hospitals Ethiopia. Study participants were born at 37 gestational...
There is little information on breast cancer (BC) survival in Ethiopia and other parts of sub-Saharan Africa. Our study estimated cumulative probabilities distant metastasis-free (MFS) patients at Addis Ababa (AA) University Radiotherapy Center, the only public oncologic institution Ethiopia. We analyzed 1,070 females with BC stage 1–3 seen 2005–2010. Patients underwent regular follow-up; estrogen receptor-positive -unknown received free endocrine treatment (an independent project funded by...
Abstract Background. Almost 500,000 women are newly diagnosed with cervical cancer (CC) every year, the majority from developing countries. There is little information on survival of these patients. Our primary objective was to evaluate consecutive CC patients presenting over 4 years at only radiotherapy center in Ethiopia. Methods. All September 2008 2012 who received and/or surgery were included (without brachytherapy). Vital status obtained through telephone contact or patient cards....
Abstract Introduction Restriction in the growth of fetus is a leading cause stillbirth, neonatal mortality, and short- long-term morbidity. Documented existing scientific evidence have shown effects maternal drugs use, alcohol drinking, tobacco smoking, cocaine use heroin on fetal restriction. However, data lacking khat chewing during pregnancy status newborn size at birth. Therefore, aim present study was to measure effect birth eastern Ethiopia. Method A cohort conducted selected health...
In contrast with breast cancers (BCs) in other parts of the world, most previous studies reported that majority BCs sub-Saharan Africa are estrogen-receptor (ER) negative. However, a recent study using US SEER database showed proportion ER-negative BC is comparable between US-born blacks and West-African born but substantially lower East African-born blacks, over 74% patients Ethiopians or Eritreans. this paper, we provide first report on Ethiopia, relation to progesterone-receptor (PgR)...
Discontinuation of radiotherapy (RT) for cervical cancer (CC) in sub-Saharan Africa is common because patient- and health service-related reasons. This analysis describes toxicities the effect adherence on survival.A total 788 patients with CC (2008-2012) who received RT at Addis Ababa University Hospital were included. External beam without brachytherapy was performed according to local guidelines. We previously described survival prognostic factors. Now we analyzed doses received....
Syzygium guineense is an important medicinal plant effective against hypertension, diabetes mellitus, and cancer but with no evidence of its teratogenicity. This study was planned to investigate the teratogenic potential S. leaves on rat embryos fetuses. Five groups Wistar albino rats, each consisting ten pregnant were used as experimental animals. Groups I-III rats treated 250, 500, 1000 mg/kg hydroethanolic extract leaves, IV V control ad libitum control, respectively. Rats during day 6–12...
Uncertainty about the causes of neonatal deaths impedes achieving global health targets to reduce mortality. Complete diagnostic autopsy (CDA) is gold standard determine cause death. However, it often difficult perform in high-burden, low-income settings. Validations more feasible methods death are needed. This prospective, multi-center study Ethiopia assessed validity minimally invasive tissue sampling (MITS) approach contribute preterm neonates compared CDA. The MITS and CDA 105 cases were...
Abstract The low overall survival rates of patients with breast cancer in sub-Saharan Africa (SSA) are driven by regionally differing tumor biology, advanced stages at diagnosis, and limited access to therapy. However, it is not known whether regional differences the composition microenvironment (TME) exist affect patients’ prognosis. In this international, multicentre cohort study, 1,237 formalin-fixed, paraffin-embedded samples, including samples “African Breast Cancer-Disparities Outcomes...
Syzygium guineense Wall. leaf is being used as a traditional medicine against hypertension and diabetes mellitus. Unlike its efficacy, the safety profile of this plant upon long-term administration has not been investigated yet. Therefore, study sub-chronic toxicity S. leaves in rats.Wistar albino rats, 10/sex/group were randomly assigned into four groups. Group I-III respectively received 250, 500, 1000 mg/kg body weight 70 % ethanol extract ofS. for 90 consecutive days. IV (control)...
Breast cancer (BC) is the leading cause of mortality among women in Ethiopia. Overall, African ancestry have highest death toll due to BC compared other racial/ethnic groups. The disparity unclear. Recently, studies conducted United States and high-income countries highlighted role microbial dysbiosis initiation, tumor growth, treatment outcome. However, extent which inter-individual differences makeup microbiota are associated with clinical histopathological outcomes Ethiopian has not been...
Many of the traditional herbal products are served to consumer without proper efficacy and safety investigations. A laboratory-based experimental study was employed investigate toxic effects Syzygium guineense leaf extract on fetal development histopathology placenta in rats. Fifty pregnant Wistar albino rats were randomly allocated into five groups, each consisting 10 S. extract, at doses 250, 500, 1000 mg/kg body weight, respectively administered groups I-III Groups four control ad libitum...
The recent development of multi-gene assays for gene expression profiling has contributed significantly to the understanding clinically and biologically heterogeneous breast cancer (BC) disease. PAM50 is one these used stratify BC patients individualize treatment. present study was conducted characterize PAM50-based intrinsic subtypes among Ethiopian patients.Formalin-fixed paraffin-embedded tissues were collected from 334 who attended five different health facilities. All samples assessed...
Background: Various medicinal plants have been studied using modern scientific approaches. These a variety of properties and various biological components that can be used to treat diseases. However, harmful effects are common clinical occurrence.Objective: This study was designed investigate toxicological assessment acute chronic methanol leaf extract Vernonia bipontini Vatke (V.bipontini V) on blood, liver kidney tissues mice.Methods: Lethal dose (LD) at which 50% experimental mice died...
Female genital tuberculosis (FGTB) is known to cause severe tubal disease leading infertility and its incidence closely parallels with the overall prevalence of (TB) in a community. Its magnitude underreported because diagnosis difficult requires invasive techniques. In this study we determined endometrial characterized isolates among women who underwent biopsy for evaluation various conditions at Tikur Anbessa Specialized Hospital (TAHS), Addis Ababa, Ethiopia. A cross sectional was...
Khat (Catha edulis Forsk) is a plant consumed by many people in Eastern Africa, including Ethiopia, and Southern Arabia to be stimulated. There are several human animal studies on khat that provide information about its toxic effects. However, the potential effects of embryos fetuses have not been elucidated. The aim present study was investigate embryotoxic fetotoxic exposure during earliest period gestation rats. Pregnant Wistar albino rats were treated with extract at 250, 500, 750 mg/kg...
It has been reported that some herbal products affect reproduction. To date, reproductive toxicity of Syzygium guineense not investigated although the plant is widely used in treating fertility related problems. Thus, objective current study was to investigate toxic effects 70% ethanol extract S. leaves on function and histopathology organs female rats.Eighty Wistar albino rats were randomly divided into four groups where each group consisted 20 rats. Rats first three treated with at doses...
Little is known about the fetal and pregnancy effects of khat chewing during pregnancy. The aim current study was to determine impact on selected outcomes in Ethiopia, 2022: A Cohort Study with a Generalized Structural Equation Modeling Analysis Approach.
Background: Respiratory disorders are the leading cause of death in preterm infants. Postmortem lung histological findings may help to confirm or exclude a clinical diagnosis. This study aims describe common postmortem pulmonary and their potential contributions neonatal mortality Ethiopia. Methods : A prospective, multicenter, cross-sectional infants was conducted five hospitals three regions total 4,919 were enrolled, these, 3,852 admitted intensive care units (NICUs). Within 28 days...
<p>Figure S1: Consort diagram of the analyzed samples</p>
<p>Figure S1: Consort diagram of the analyzed samples</p>
<p>Figure S2: TILs in SSA</p>
<p>Figure S3: Immune cell subpopulations in SSA</p>
<p>Figure S2: TILs in SSA</p>