A5040848104- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Global Cancer Incidence and Screening
- Olfactory and Sensory Function Studies
- T-cell and B-cell Immunology
- Circular RNAs in diseases
- Immune Cell Function and Interaction
- Biochemical Analysis and Sensing Techniques
- Health Systems, Economic Evaluations, Quality of Life
- vaccines and immunoinformatics approaches
- Genetic diversity and population structure
- Animal Behavior and Reproduction
- Molecular Biology Techniques and Applications
- Algorithms and Data Compression
- melanin and skin pigmentation
- Cell Adhesion Molecules Research
- Genetic Associations and Epidemiology
- Reproductive System and Pregnancy
- Connexins and lens biology
- Economic and Financial Impacts of Cancer
- Cancer Cells and Metastasis
- Cerebrovascular and genetic disorders
- Genomics and Phylogenetic Studies
Martin Luther University Halle-Wittenberg
2023-2024
Luther University
2024
Universität Ulm
2017-2021
Universidade Federal do Paraná
2005-2019
Leibniz Institute for Zoo and Wildlife Research
2010-2016
Hospital do Divino Espírito Santo
2014
Freie Universität Berlin
2009-2011
Charité - Universitätsmedizin Berlin
2008-2011
Abstract Major histocompatibility complex (MHC) genes play a pivotal role in vertebrate self/nonself recognition, parasite resistance and life history decisions. In evolutionary terms, the MHC’s exceptional diversity is likely maintained by sexual pathogen-driven selection. Even though MHC-dependent mating preferences have been confirmed for many species, sensory genetic mechanisms underlying mate recognition remain cryptic. Since olfaction crucial social communication vertebrates, variation...
AbstractSelf/nonself perception governs mate selection in most eukaryotic species. It relies on a number of natural barriers that act before, during, and after copulation. These hurdles prevent costly investment into an embryo with potentially suboptimal genetic immunological properties aim at discouraging fertilization when male female gametes exhibit extensive sharing alleles. Due to the fact several genes belonging extended major histocompatibility complex (xMHC) carry out crucial immune...
Abstract The low overall survival rates of patients with breast cancer in sub-Saharan Africa (SSA) are driven by regionally differing tumor biology, advanced stages at diagnosis, and limited access to therapy. However, it is not known whether regional differences the composition microenvironment (TME) exist affect patients’ prognosis. In this international, multicentre cohort study, 1,237 formalin-fixed, paraffin-embedded samples, including samples “African Breast Cancer-Disparities Outcomes...
Abstract Background In Ethiopia, both incidence and mortality of cervical cancer are relatively high. Screening services, which were implemented during the past few years, currently being expanded. The World Health Organization recommends patients with a positive VIA (visual inspection acetic acid) result should immediately receive treatment followed by rescreening after 1 year as precancerous lesions can reoccur or become residential despite treatment. Materials Methods logbooks dating...
Abstract Sexual selection involving genetically disassortative mate choice is one of several evolutionary processes that can maintain or enhance population genetic variability. Examples reproductive systems in which choosers (generally females) select mates depending on their major histocompatibility complex ( MHC ) genes have been reported for vertebrate species. Notably, the role ‐dependent not mating contexts, but other kinds social interactions such as establishment systems, has yet...
Summary A high proportion of human recurrent spontaneous abortions ( RSA ) remain unexplained. The possible association between and different genetic polymorphisms within the leucocyte antigen system HLA system, major histocompatibility complex) has been investigated with conflicting results since many decades. Here, we describe a case–control study 136 S outhern B razilian women predominantly E uropean ancestry (75 control 61 cases unexplained ). We relationship alleles genotypes from two...
The products of the genes major histocompatibility complex (MHC) are known to be drivers pathogen resistance and sexual selection enhancing offspring genetic diversity. MHC further influences individual odour types social communication. However, little is about receptors their volatile ligands that involved in this type chemical Here, we have investigated chemosensory receptor ultimately enable females assess male through cues. As a model, used an invasive population North American raccoons...
Abstract Genotyping complex multigene families in novel systems is particularly challenging. Target primers frequently amplify simultaneously multiple loci leading to high PCR and sequencing artefacts such as chimeras allele amplification bias. Most genotyping pipelines have been validated nonmodel whereby the real genotype unknown generation of may be highly repeatable. Further hindering accurate genotyping, relationship between complexity (i.e. number alleles per genotype) within a remains...
Smoking behavior has been associated in two independent European cohorts with the most common Caucasian human leukocyte antigen (HLA) haplotype (A1-B8-DR3). We aimed to test whether polymorphic members of odorant receptor (OR) clusters within extended HLA complex might be responsible for observed association, by genotyping a cohort Hungarian women which mentioned association had found. One hundred and eighty haplotypes from Centre d'Etude du Polymorphisme Humain families were analyzed silico...
Congenital orbital teratoma associated with a PTCH1 mutation syndrome (NBCCS), is rare autosomal dominant disorder caused by mutations in the gene and shows high level of penetrance variable expressivity.The characterized developmental abnormalities or neoplasms diagnosed 2 major criteria, 1 minor criteria.Here, we report new clinical manifestation this boy affected NBCCS who had congenital at birth.Later, age 15 years, he presented 4 criteria NBCCS, including multiple basal cell carcinoma...
Introduction Breast cancer (BC) is the most common malignant neoplasm among women in Addis Ababa, Ethiopia. The willingness and ability to pay (WATP) for treatment a contributing factor utilization of health care services. World Health Organization Cancer Initiative calls 80% patients complete multimodality indicates payment as central improve BC outcome. objectives this study are identify how much female paid Ababa treatment, their WATP factors that affect WATP. Methods researchers...
Hintergrund und Fragestellung Das Mammakarzinom ist in den meisten afrikanischen Ländern die Krebserkrankung mit der höchsten Inzidenz einer deutlich höheren Sterberate im Vergleich zu westlichen (teilweise> 50% versus 10% nach fünf Jahren). Genexpressionsprofile ermöglichen Kategorisierung vom klinisch bzw. therapierelevante intrinsische Subtypen (IS). Ziel Studie war, das Überleben von äthiopischen Patientinnen entsprechend IS analysieren.
<title>Abstract</title> Pathogen-mediated balancing selection shapes host ecology and evolution across the tree of life, fueling a co-evolutionary arms race based on frequency-dependent adaptations hosts counter-adaptations pathogens. While rare immune genotypes are predicted to be more resistant pathogens, evidence for this allele-advantage negative feedbacks has only been observed in model species or inferred from short-term field observations. Evidence long-term data wild populations is...
Systemic therapy plays a major part in the cure of patients with early breast cancer (eBC). However, personalized treatment concepts are required to avoid potentially harmful overtreatment. Biomarkers pivotal for individualized therapy. The Notch signalling pathway is widely considered as suitable prognostic or predictive marker eBC. This study aimed primarily at assessing relationship between NOTCH1 mRNA expression levels and histopathological features tumors, well clinical characteristics...
Abstract Background To assess population-based quality of cancer care in sub-Saharan Africa and to identify specific gaps joint opportunities, we assessed concordance diagnostics treatments with National Comprehensive Cancer Network Harmonized Guidelines for leading types 10 countries. Methods Adult patients female breast cancer, cervical colorectal non-Hodgkin lymphoma, prostate were randomly drawn from 11 registries. Guideline treatment was using clinical records. In a subcohort 906...
<p>Figure S1: Consort diagram of the analyzed samples</p>
<p>Figure S1: Consort diagram of the analyzed samples</p>
<p>Figure S2: TILs in SSA</p>
<p>Figure S3: Immune cell subpopulations in SSA</p>
<p>Figure S2: TILs in SSA</p>