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Annelle Zietsman

ORCID: 0009-0006-6406-6887
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A5085150949
Research Areas
  • Cancer Immunotherapy and Biomarkers
  • Immunotherapy and Immune Responses
  • Ferroptosis and cancer prognosis
  • Cancer Genomics and Diagnostics
  • Global Cancer Incidence and Screening
  • Circular RNAs in diseases
  • Health Systems, Economic Evaluations, Quality of Life
  • Economic and Financial Impacts of Cancer
  • Cancer Cells and Metastasis
  • Liver Disease Diagnosis and Treatment

African Field Epidemiology Network
 2024

National Art Gallery of Namibia
 2023-2024

 Regional Variation in the Tumor Microenvironment, Immune Escape and Prognostic Factors in Breast Cancer in Sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

Abstract The low overall survival rates of patients with breast cancer in sub-Saharan Africa (SSA) are driven by regionally differing tumor biology, advanced stages at diagnosis, and limited access to therapy. However, it is not known whether regional differences the composition microenvironment (TME) exist affect patients’ prognosis. In this international, multicentre cohort study, 1,237 formalin-fixed, paraffin-embedded samples, including samples “African Breast Cancer-Disparities Outcomes...

10.1158/2326-6066.cir-22-0795 article EN Cancer Immunology Research 2023-04-14
 NCCN guideline-concordant cancer care in Sub-Saharan Africa A population-based multi-country study of five cancers
OPENALEX - Publications 
Nikolaus Christian Simon Mezger Tobias Paul Seraphin Robert Ballé Mirko Griesel Yvonne Walburga Joko-Fru and 21 more Lucia Hämmerl Jana Feuchtner Biying Liu Annelle Zietsman Bakarou Kamaté Freddy Houéhanou Rodrigue Gnangnon Franck Gnahatin Dimitry Moudiongui Mboungou Mathewos Assefa Phoebe Mary Amulen Gladys Chesumbai Tatenda Chingonzoh Cesaltina Feirreira Lorenzoni Anne Korir Pablo Santos J. Mezger Haifa Kathrin Al‐Ali Rafael Mikolajczyk D. Max Parkin Ahmedin Jemal Eva Johanna Kantelhardt

Abstract Background To assess population-based quality of cancer care in sub-Saharan Africa and to identify specific gaps joint opportunities, we assessed concordance diagnostics treatments with National Comprehensive Cancer Network Harmonized Guidelines for leading types 10 countries. Methods Adult patients female breast cancer, cervical colorectal non-Hodgkin lymphoma, prostate were randomly drawn from 11 registries. Guideline treatment was using clinical records. In a subcohort 906...

10.1093/jnci/djae221 article EN cc-by JNCI Journal of the National Cancer Institute 2024-09-12
 Supplementary Figure 1 from Regional variation in the tumor microenvironment, immune escape and prognostic factors in breast cancer in sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S1: Consort diagram of the analyzed samples</p>

10.1158/2326-6066.27026444.v1 preprint EN 2024-09-16
 Supplementary Figure 1 from Regional variation in the tumor microenvironment, immune escape and prognostic factors in breast cancer in sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S1: Consort diagram of the analyzed samples</p>

10.1158/2326-6066.27026444 preprint EN 2024-09-16
 Supplementary Figure 2 from Regional variation in the tumor microenvironment, immune escape and prognostic factors in breast cancer in sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S2: TILs in SSA</p>

10.1158/2326-6066.27026441 preprint NL 2024-09-16
 Supplementary Figure 3 from Regional variation in the tumor microenvironment, immune escape and prognostic factors in breast cancer in sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S3: Immune cell subpopulations in SSA</p>

10.1158/2326-6066.27026438 preprint FR 2024-09-16
 Supplementary Figure 2 from Regional variation in the tumor microenvironment, immune escape and prognostic factors in breast cancer in sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S2: TILs in SSA</p>

10.1158/2326-6066.27026441.v1 preprint NL 2024-09-16
 Supplementary Figure 4 from Regional variation in the tumor microenvironment, immune escape and prognostic factors in breast cancer in sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S4:PD-L1 expression and cytotoxicity</p>

10.1158/2326-6066.27026435 preprint EN 2024-09-16
 Supplementary Figure 3 from Regional variation in the tumor microenvironment, immune escape and prognostic factors in breast cancer in sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S3: Immune cell subpopulations in SSA</p>

10.1158/2326-6066.27026438.v1 preprint FR 2024-09-16
 Supplementary Figure 5 from Regional variation in the tumor microenvironment, immune escape and prognostic factors in breast cancer in sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S5: MHC I expression in SSA</p>

10.1158/2326-6066.27026432 preprint EN 2024-09-16
 Supplementary Figure 4 from Regional variation in the tumor microenvironment, immune escape and prognostic factors in breast cancer in sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S4:PD-L1 expression and cytotoxicity</p>

10.1158/2326-6066.27026435.v1 preprint EN 2024-09-16
 Supplementary Figure 5 from Regional variation in the tumor microenvironment, immune escape and prognostic factors in breast cancer in sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S5: MHC I expression in SSA</p>

10.1158/2326-6066.27026432.v1 preprint EN 2024-09-16
 Supplementary Figure 6 from Regional variation in the tumor microenvironment, immune escape and prognostic factors in breast cancer in sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S6: Multivariate Cox regression analysis of patient's survival.</p>

10.1158/2326-6066.27026429.v1 preprint EN 2024-09-16
 Supplementary Figure 6 from Regional variation in the tumor microenvironment, immune escape and prognostic factors in breast cancer in sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S6: Multivariate Cox regression analysis of patient's survival.</p>

10.1158/2326-6066.27026429 preprint EN 2024-09-16
 Supplementary Figure 6 from Regional Variation in the Tumor Microenvironment, Immune Escape and Prognostic Factors in Breast Cancer in Sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S6: Multivariate Cox regression analysis of patient's survival.</p>

10.1158/2326-6066.23283420 preprint EN cc-by 2023-06-02
 Supplementary Figure 3 from Regional Variation in the Tumor Microenvironment, Immune Escape and Prognostic Factors in Breast Cancer in Sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S3: Immune cell subpopulations in SSA</p>

10.1158/2326-6066.23283429 preprint FR cc-by 2023-06-02
 Supplementary Figure 4 from Regional Variation in the Tumor Microenvironment, Immune Escape and Prognostic Factors in Breast Cancer in Sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S4:PD-L1 expression and cytotoxicity</p>

10.1158/2326-6066.23283426 preprint EN cc-by 2023-06-02
 Supplementary Figure 1 from Regional Variation in the Tumor Microenvironment, Immune Escape and Prognostic Factors in Breast Cancer in Sub-Saharan Africa
OPENALEX - Publications 
Marcus Bauer Martina Vetter Kathrin Stückrath Meron Yohannes Zelalem Desalegn and 27 more Tewodros Yalew Yonas Bekuretsion Tariku W. Kenea Maureen Joffe Eunice J. van den Berg Julien I. Nikulu Bakarou Kamaté Shyam S. Manraj Olufemi J. Ogunbiyi Ima-Obong Ekanem Festus Igbinoba Mohenou Diomande Clement Adebamowo Charles P. Dzamalala Angelica A. Anele Annelle Zietsman Moses Galukande Milena Foerster Isabel dos‐Santos‐Silva Biying Liu Pablo Santos Ahmedin Jemal Tamrat Abebe Claudia Wickenhauser Barbara Seliger Valerie McCormack Eva Johanna Kantelhardt

<p>Figure S1: Consort diagram of the analyzed samples</p>

10.1158/2326-6066.23283435 preprint EN cc-by 2023-06-02
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