A5057209357- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Global Cancer Incidence and Screening
- Antibiotic Resistance in Bacteria
- Circular RNAs in diseases
- Urinary Tract Infections Management
- Antibiotic Use and Resistance
- Hepatitis B Virus Studies
- Nosocomial Infections in ICU
- Infection Control in Healthcare
- Vibrio bacteria research studies
- Cancer Cells and Metastasis
- COVID-19 epidemiological studies
- Mosquito-borne diseases and control
- Liver Disease Diagnosis and Treatment
- Bacterial Identification and Susceptibility Testing
- Vaccine Coverage and Hesitancy
- COVID-19 diagnosis using AI
- HIV/AIDS Research and Interventions
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and Mental Health
- Malaria Research and Control
- HIV, Drug Use, Sexual Risk
Martin Luther University Halle-Wittenberg
2023-2024
Addis Ababa University
2015-2024
Wollega University
2019-2024
Tikur Anbessa Hospital
2023
Saba University School of Medicine
2020
Armauer Hansen Research Institute
2020
Bahir Dar University
2020
The COVID-19 pandemic is impacting the global community in many ways. Combating requires a coordinated effort through engaging public and service providers preventive measures. government of Ethiopia had already announced prevention guidelines for public. However, there scarcity evidence-based data on knowledge, attitude, practice (KAP) response regarding COVID-19.This study aimed to assess KAP providers' preparedness towards Addis Ababa, Ethiopia.A community-based cross-sectional was...
Hepatitis, a highly contagious viral infection, is one of the leading killer diseases globally caused by hepatitis virus. Among existing causes for hepatic failure, B virus (HBV) plays significant role with devastating implications, especially when combined other infections such as human immunodeficiency (HIV). Co-infection and HIV leads to increased morbidity mortality compared independent HBV infections. In this study, we aimed assess seroprevalence coinfection associated risk factors...
Urinary tract infection (UTI) is one of the commonest infections affecting millions worldwide, especially pregnant women. It can lead to poor maternal and perinatal outcomes. Untreated UTI be associated with serious obstetric complications. So objective present study was determine bacterial profile, antibiotic susceptibility pattern factors among women in Goba Sinana Woredas, Bale Zone, Southeast Ethiopia.The overall prevalence 44/169 (26%) 18/51 (35.3%) symptomatic 26/118 (22%) asymptomatic...
Background Bloodstream infection due to beta-lactamase and carbapenemase-producing gram-negative bacteria poses a substantial challenge the effectiveness of antimicrobial treatments. Therefore, this study aimed investigate magnitude beta-lactamase, bacteria, associated risk factors bloodstream infections in patients at tertiary care hospital, Addis Ababa, Ethiopia. Methods An institutional-based cross-sectional was conducted with convenience sampling techniques from September 2018 March...
Background The World Health Organization has declared that infection with SARS-CoV-2 is a pandemic. Experiences SARS in 2003 and have shown health professionals are at higher risk of contracting COVID-19. Hence, it been recommended aperiodic wide-scale assessment the knowledge preparedness regarding current COVID-19 pandemic critical. Objectives This study aimed to assess among selected hospitals Addis Ababa, Ethiopia. Methods A facility-based cross-sectional was conducted from last week...
Background Urinary tract infections are the most common causes of morbidity and mortality in patients with cancer. The emergence multiple-drug-resistant (MDR) strains gram-negative bacteria causing urinary infection has become a serious concern cancer patients. Therefore, present study aimed to determine spectrum antibiotic resistance pattern bacterial isolates related among at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. Methods materials Hospital based prospective...
Abstract Background Anti-SARS-CoV-2 antibody tests are being increasingly used for sero-epidemiological purposes to provide better understanding of the extent infection in community, and monitoring progression COVID-19 epidemic. We conducted sero-prevalence study estimate prior with SARS-CoV-2 Addis Ababa. Methods A cross-sectional was done from April 23 28, 2020 among 301 randomly selected residents Ababa; no known history contact confirmed person. Interviews on socio demographic...
Abstract The low overall survival rates of patients with breast cancer in sub-Saharan Africa (SSA) are driven by regionally differing tumor biology, advanced stages at diagnosis, and limited access to therapy. However, it is not known whether regional differences the composition microenvironment (TME) exist affect patients’ prognosis. In this international, multicentre cohort study, 1,237 formalin-fixed, paraffin-embedded samples, including samples “African Breast Cancer-Disparities Outcomes...
Microbial contamination of the hospital environment plays an important role in spread healthcare-associated infections (HCAIs). This study was conducted to determine bacterial contamination, profiles, and antimicrobial susceptibility pattern isolates from environmental surfaces medical equipment.A cross-sectional at Tikur Anbessa Specialized Hospital (TASH) June September 2018. A total 164 inanimate located intensive care units (ICUs) operation theaters (OTs) were swabbed. All identified by...
Resistance to anti-malarials is a major challenge for effective malaria control in sub-Saharan Africa. This triggered need routine monitoring of the efficacy antimalarial drugs every two years all endemic countries. Chloroquine remained drug choice treatment vivax Ethiopia. Though, strong scientific evidence chloroquine resistance P.vivax that could have brought change regimen yet be established Ethiopia, continuous and regular drug's critical establishing rational anti-malarial policies....
Breast cancer (BC) is the leading cause of mortality among women in Ethiopia. Overall, African ancestry have highest death toll due to BC compared other racial/ethnic groups. The disparity unclear. Recently, studies conducted United States and high-income countries highlighted role microbial dysbiosis initiation, tumor growth, treatment outcome. However, extent which inter-individual differences makeup microbiota are associated with clinical histopathological outcomes Ethiopian has not been...
Malaria is a complex disease, which varies in its epidemiology and clinical manifestation. Although artemether-lumefantrine has been used as first-line drug for uncomplicated Plasmodium falciparum malaria Bahir Dar district since 2004, efficacy not yet assessed. The main objective of this study was to quantify the proportion patients with who were prescribed failed treatment after 28-day follow-up. research team attempted conduct an observational cohort on assessment therapeutic safety aged...
The recent development of multi-gene assays for gene expression profiling has contributed significantly to the understanding clinically and biologically heterogeneous breast cancer (BC) disease. PAM50 is one these used stratify BC patients individualize treatment. present study was conducted characterize PAM50-based intrinsic subtypes among Ethiopian patients.Formalin-fixed paraffin-embedded tissues were collected from 334 who attended five different health facilities. All samples assessed...
Health professionals are exposed to a wide range of hazards in the workplace. Needle stick injuries have been recognized as one occupational hazards. Healthcare worker handling sharp devices or equipment is at risk exposure blood borne pathogens. Despite burden potential exposures, Ethiopia, there only few researches that conducted; result clearly paucity information on this regard. The aim research conducted was determine epidemiology needle stick-sharp and high exposures among health...
Background: Hepatitis B is a global public health problem and major cause of liver disease, including chronic hepatitis, cirrhosis cancer. Pregnant women with hepatitis virus infection are reservoir for the do have high potential to transmit it their fetuses newborns. The objective study was investigatesero-prevalence surface antigen assesses risk factors among pregnant in Ethiopia. Methods: Institution based cross-sectional conducted from July September, 2014 A pretested structured...
Purpose: Escherichia coli strains that produce extended-spectrum ß-lactamase (ESBL) and carbapenemase are among the major threats to global health. The objective of present study was determine distribution genes multidrug-resistant (MDR) ESBL-producing Diarrheagenic E. (DEC) pathotypes isolated from under-five children in Ethiopia. Patients Methods: A cross-sectional conducted Addis Ababa Debre Berhan, It a health-facility-based between December 2020 August 2021. total 476 participated...
When faced with a public health problem such as the COVID-19 pandemic, devising test an accurate and rapid diagnostic capacity is critical to contain disease. We compared performance of antigen in comparison reference method, namely real-time polymerase chain reaction (RT-PCR) assay.
Abstract Background Trachoma, caused by the bacteria Chlamydia trachomatous, is a contagious eye condition that frequently affects children and quickly spreads from child to caregiver. The study aimed assess distribution of active trachoma its associated risk factors among 1–9 years aged in Households Sasiga Rural District, Western Ethiopia, 2022. Methods A community-based cross-sectional was conducted 577 randomly selected March May multistage sampling technique used. Data collected through...
<p>Figure S1: Consort diagram of the analyzed samples</p>
<p>Figure S1: Consort diagram of the analyzed samples</p>
<p>Figure S2: TILs in SSA</p>
<p>Figure S3: Immune cell subpopulations in SSA</p>
<p>Figure S2: TILs in SSA</p>