A5075185509- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Global Cancer Incidence and Screening
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Economic and Financial Impacts of Cancer
- Cervical Cancer and HPV Research
- Colorectal Cancer Screening and Detection
- Cancer Risks and Factors
- Circular RNAs in diseases
- BRCA gene mutations in cancer
- Breast Cancer Treatment Studies
- Cancer survivorship and care
- Family Support in Illness
- Cancer Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Viral-associated cancers and disorders
- Global Health and Surgery
- Data-Driven Disease Surveillance
- Cancer Cells and Metastasis
- Legal and Policy Issues
- Hernia repair and management
- Maternal and Perinatal Health Interventions
- Nail Diseases and Treatments
- Liver Disease Diagnosis and Treatment
Federal Medical Centre
2016-2025
Hudson Institute
2023
John Wiley & Sons (United States)
2023
Imo State University
2014
Imo State University Teaching Hospital
2009
BackgroundBreast cancer is the second leading cause of death from in women sub-Saharan Africa, yet there are few well characterised large-scale survival studies with complete follow-up data. We aimed to provide robust estimates this setting and apportion gaps.MethodsThe African Breast Cancer-Disparities Outcomes (ABC-DO) prospective cohort study was done at eight hospitals across five countries (Namibia, Nigeria, South Uganda, Zambia). prospectively recruited (aged ≥18 years) who attended...
Improving breast cancer survival in sub-Saharan Africa (SSA) is urgently needed, requiring early diagnosis and improved access to treatment. However, data on the types of barriers receiving therapy this region are limited have not been compared between different SSA countries treatment settings. In health care settings across Uganda, Nigeria Namibian sites prospective African Breast Cancer - Disparities Outcomes cohort study, we assessed percentage newly diagnosed patients who received...
Breast cancer (BC) survival rates in sub-Saharan Africa (SSA) are low part due to advanced stage at diagnosis. As one component of a study the entire journey SSA women with BC, we aimed identify shared and setting-specific drivers BC. Women newly diagnosed multicountry African Cancer-Disparities Outcomes (ABC-DO) completed baseline interview their information was extracted from medical records. Ordinal logistic regression used estimate odds ratios (OR) 95% confidence intervals (CI) for (I,...
Introduction Sub-Saharan African (SSA) women with breast cancer (BC) have low survival rates from this potentially treatable disease. An understanding of context-specific societal, health-systems and woman-level barriers to BC early detection, diagnosis treatment are needed. Methods The Breast Cancer—Disparities in Outcomes (ABC-DO) is a prospective hospital-based study overall survival, impact on quality life (QOL) delays along the journey SSA. ABC-DO currently recruiting Namibia, Nigeria,...
Most breast cancer patients in sub-Saharan Africa are diagnosed at advanced stages after prolonged symptomatic periods. In the multicountry African Breast Cancer-Disparities Outcomes cohort, we dissected diagnostic journey to inform downstaging interventions. At hospital presentation for cancer, women recalled their journey, including dates of first noticing symptoms and health-care provider (HCP) visits. Negative binomial regression models were used identify correlates length journey. Among...
Abstract We examined the geospatial dimension of delays to diagnosis breast cancer in a prospective study 1541 women newly diagnosed African Breast Cancer—Disparities Outcomes (ABC‐DO) Study. Women were recruited at treatment facilities Namibia, Nigeria, Uganda and Zambia. The baseline interview included information used generate features: urban/rural residence, travel mode facility straight‐line distances from home first‐care provider diagnostic/treatment facility, categorized into...
Low breast cancer survival in sub-Saharan Africa's young population increases the likelihood that deaths result maternal orphans, ie, children (<18 years) losing their mother.
Abstract The low overall survival rates of patients with breast cancer in sub-Saharan Africa (SSA) are driven by regionally differing tumor biology, advanced stages at diagnosis, and limited access to therapy. However, it is not known whether regional differences the composition microenvironment (TME) exist affect patients’ prognosis. In this international, multicentre cohort study, 1,237 formalin-fixed, paraffin-embedded samples, including samples “African Breast Cancer-Disparities Outcomes...
There is an urgent need to improve breast cancer survival in sub-Saharan Africa. Geospatial barriers delay diagnosis and treatment, but their effect on these settings not well understood. We examined geospatial disparities 4-year the African Breast Cancer-Disparities Outcomes cohort. In this prospective cohort study, women (aged ≥18 years) newly diagnosed with were recruited from eight hospitals Namibia, Nigeria, South Africa, Uganda, Zambia. They reported sociodemographic information...
Accurate survival estimates are needed for guiding cancer control efforts in sub-Saharan Africa, but previous studies have been hampered by unknown biases due to excessive loss follow-up (LTFU). In the African Breast Cancer-Disparities Outcomes Study, a prospective breast cohort study, we implemented active mobile health follow-up, telephoning each woman or her next-of-kin (NOK) trimonthly on phone update information vital status. Dates of every contact with women/NOK were analyzed from...
Abstract The presence of preexisting morbidities poses a challenge to cancer patient care. There is little information on the profile and prevalence multi‐morbidities in breast patients across middle income countries (MIC) lower (LIC) sub‐Saharan Africa (SSA). African Breast Cancer–Disparities Outcomes (ABC‐DO) cohort spans upper MICs South Namibia, Zambia Nigeria LIC Uganda. At diagnosis, seven were assessed: obesity, hypertension, diabetes, asthma/chronic obstructive pulmonary disease,...
Abstract Background Arm and shoulder problems (ASP), including lymphedema, were common among women with breast cancer in high-income countries before sentinel lymph node biopsy became the standard of care. Although ASP impair quality life, as they affect daily life activities, their frequency determinants Sub-Saharan Africa remain unclear. Methods All newly diagnosed at Namibian, Ugandan, Nigerian, Zambian sites African Breast Cancer-Disparities Outcomes (ABC-DO) cohort study included. At...
<p>Figure S1: Consort diagram of the analyzed samples</p>
<p>Figure S1: Consort diagram of the analyzed samples</p>
<p>Figure S2: TILs in SSA</p>
<p>Figure S3: Immune cell subpopulations in SSA</p>
<p>Figure S2: TILs in SSA</p>
<p>Figure S4:PD-L1 expression and cytotoxicity</p>