Olufemi J. Ogunbiyi
A5084899985- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Global Cancer Incidence and Screening
- Prostate Cancer Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Prostate Cancer Treatment and Research
- Colorectal Cancer Screening and Detection
- Cervical Cancer and HPV Research
- Genetic Associations and Epidemiology
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Childhood Cancer Survivors' Quality of Life
- Cancer-related molecular mechanisms research
- Colorectal Cancer Treatments and Studies
- Endometrial and Cervical Cancer Treatments
- Colorectal and Anal Carcinomas
- Ovarian cancer diagnosis and treatment
- Radiomics and Machine Learning in Medical Imaging
- Renin-Angiotensin System Studies
- Genetic factors in colorectal cancer
- Hormonal Regulation and Hypertension
- Glioma Diagnosis and Treatment
- Economic and Financial Impacts of Cancer
- Helicobacter pylori-related gastroenterology studies
University College Hospital, Ibadan
2011-2025
University of Ibadan
2015-2025
University College London
1997-2023
Northwestern University
2023
Great Ormond Street Hospital
2023
NorthShore University HealthSystem
2022
London Women's Clinic
2021
Beth Israel Deaconess Medical Center
2018
Dana-Farber Cancer Institute
2018
The Royal Free Hospital
2006-2017
Worldwide data for cancer survival are scarce. We aimed to initiate worldwide surveillance of by central analysis population-based registry data, as a metric the effectiveness health systems, and inform global policy on control.
Global inequalities in access to health care are reflected differences cancer survival. The CONCORD programme was designed assess worldwide and trends population-based In this study, we aimed estimate survival globally for several subtypes of childhood leukaemia. Cancer registries participating were asked submit tumour registrations all children aged 0-14 years who diagnosed with leukaemia between Jan 1, 1995, Dec 31, 2009, followed up until 2009. Haematological malignancies defined by...
Body mass index (BMI) is the most commonly used measure of obesity. Recently, some investigators have advocated direct measurement adiposity rather than use BMI. This study was undertaken to determine ability BMI predict body fat levels in three populations West African heritage living different environments. A total 1,054 black men and women were examined Nigeria, Jamaica, United States during 1994 1995. standardized protocol height, weight, waist hip circumferences, blood pressure at all...
Breast cancer (BC) is the leading cause of in sub-Saharan Africa (SSA) with rapidly increasing incidence rates reported Uganda and Zimbabwe. However, magnitude these rising trends premenopausal postmenopausal women unknown most African countries. We used data from Cancer Registry Network on incident breast cancers 11 population-based registries 10 countries representing each four SSA regions. explored changes among before after age 50 by calendar period and, where possible, generational...
BackgroundLeukaemias comprise a heterogenous group of haematological malignancies. In CONCORD-3, we analysed data for children (aged 0–14 years) and adults 15–99 diagnosed with malignancy during 2000–14 in 61 countries. Here, aimed to examine worldwide trends survival from leukaemia, by age morphology, young patients 0–24 years).MethodsWe 258 population-based cancer registries countries participating CONCORD-3 that submitted on leukaemia. We grouped as (0–14 years), adolescents (15–19 (20–24...
A rare African ancestry-specific germline deletion variant in HOXB13 (X285K, rs77179853) was recently reported Martinican men with early-onset prostate cancer. Given the role of variation cancer, we investigated association between X285K and cancer risk a large sample 22 361 ancestry men, including 11 688 cases. The allele present only West ancestry, an frequency that ranged from 0.40% Ghana 0.31% Nigeria to 0% Uganda South Africa, range frequencies admixed North America Europe (0-0.26%)....
Abstract Background: Prostate cancer is the leading in men sub-Saharan Africa (SSA) regarding incidence and mortality. Published data from a few registries SSA suggest that rates are still rising, but there little comprehensive information on time trends of prostate incidence. Methods: We analyzed registry 13,170 incident cases aged 40 years or above, 12 population-based 11 countries, with at least 10-year span comparable data. Results: observed an increase cumulative risks (CR)...
Abstract Background Genome-wide association studies do not always replicate well across populations, limiting the generalizability of polygenic risk scores (PRS). Despite higher incidence and mortality rates prostate cancer in men African descent, much what is known about genetics comes from populations European descent. To understand how genetic predictions perform different we evaluated test characteristics PRS three previous using data UK Biobank a novel dataset 1298 cases 1333 controls...
Survival is a key metric of the effectiveness health system in managing cancer. We set out to provide comprehensive examination worldwide variation and trends survival from brain tumors adults, by histology.We analyzed individual data for adults (15-99 years) diagnosed with tumor (ICD-O-3 topography code C71) during 2000-2014, regardless behavior. Data underwent 3-phase quality control as part CONCORD-3. estimated net 11 histology groups, using unbiased nonparametric Pohar Perme...
Within the context of an international collaborative study evolution hypertension in black diaspora, we determined allelic distribution candidate genes for renin-angiotensin system three populations African origin. The insertion/deletion (I/D) polymorphism angiotensin-converting enzyme (ACE) and M235T T174M variants angiotensinogen (AGT) gene were examined individuals from Nigeria, Jamaica, United States. Large differences prevalence recorded door-to-door surveys, ranging 16% Nigeria to 33%...
Background We evaluated the association among M235T and T174M variants of angiotensinogen (AGT) gene, plasma AGT, hypertension status in a sample Nigerians. Methods Results Participants were selected from extremes blood pressure distribution obtained population survey 2509 men women aged 25 to 74 years. Cases (hypertensive subjects) individuals who had high or taking antihypertensive medication, control subjects with low never taken medication. found significant between variant AGT level....
Abstract Background: Bone tumours constitute about 0.5% of documented cancer incidence. A previous study conducted in our hospital showed an incidence 0.53% for primary malignant bone tumour (PMBT). Some the predisposing factors to development these include trauma, irradiation, foreign bodies, and genetic malfunctioning or mutation. They present symptoms, such as pain, swelling tenderness affected bone, weight loss, some cases, first presentation may be a pathological fracture through...
This study aimed to identify and quantify the relative collective contributions of lifestyle, behavioral, biological risk factors cervical HPV infections among female sex workers (FSWs) in Ibadan, Nigeria. cross-sectional was part Sexual Behavior Infections Nigerians Ibadan project involved 182 FSWs for whom complete data on genotypes were available. Quantile-based g-computation employed assess any HPV/hrHPV multiple HPV/hrHPV. The contribution all selected high-risk 2.47 (95% CI:...
Background The relationship between circulating levels of angiotensinogen and hypertension in the epidemio-logic setting has not been studied much. Recent findings related to association polymorphisms gene have generated new interest this potential pathway hypertension. Objectives To examine environmental factors associated with as determinants populations African origin. Methods We recruited 1557 participants from communities Nigeria (n = 611), Zimbabwe 161), Jamaica 476), Maywood,...
The desmocollins are members of the desmosomal cadherin family cell-cell adhesion molecules. They essential constituents desmosomes, intercellular junctions that play a critical role in maintenance tissue integrity epithelia and cardiac muscle. In humans, three (Dsc1, Dsc2 Dsc3) have been described. exhibit tissue-specific patterns expression; only is expressed normal colonic epithelium. We found switching between sporadic colorectal adenocarcinoma with reduction protein (in 8/16 samples...