A5083508564- Plant Toxicity and Pharmacological Properties
- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Sesquiterpenes and Asteraceae Studies
- Parasites and Host Interactions
- Natural product bioactivities and synthesis
- Allelopathy and phytotoxic interactions
- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Essential Oils and Antimicrobial Activity
- Glioma Diagnosis and Treatment
- Pain Mechanisms and Treatments
- Pancreatitis Pathology and Treatment
- Teratomas and Epidermoid Cysts
- Complement system in diseases
- Global Public Health Policies and Epidemiology
- Hepatitis Viruses Studies and Epidemiology
- Toxin Mechanisms and Immunotoxins
- Phenothiazines and Benzothiazines Synthesis and Activities
- Plant biochemistry and biosynthesis
- Immune Response and Inflammation
- Business and Management Studies
- Morinda citrifolia extract uses
- Medicinal Plant Extracts Effects
- Tumors and Oncological Cases
Universidade do Estado do Rio de Janeiro
2023
Hospital Universitário Pedro Ernesto
2023
Universidade Federal de Santa Catarina
2008-2009
Universidade de São Paulo
1979-2008
Instituto de Ciências Farmacêuticas
2008
Universidade de Ribeirão Preto
2007
Instituto de Medicina Tropical
1979-1982
Quercetin is a plant-derived flavonoid widely known by its anti-oxidant and anti-inflammatory properties, but oral bioavailability very poor this becomes difficult to assess therapeutic potential. Here we have compared the effect of quercetin-loaded microemulsion (QU-ME) quercetin suspension (QU-SP) in an experimental model airways allergic inflammation. Mice received daily doses QU-ME (3 or 10mg/kg; oil-in-water content 0.02:0.2:1 lecithin:castor oil:Solutol HS15((R))), QU-SP [10mg/kg,...
BackgroundLeukaemias comprise a heterogenous group of haematological malignancies. In CONCORD-3, we analysed data for children (aged 0–14 years) and adults 15–99 diagnosed with malignancy during 2000–14 in 61 countries. Here, aimed to examine worldwide trends survival from leukaemia, by age morphology, young patients 0–24 years).MethodsWe 258 population-based cancer registries countries participating CONCORD-3 that submitted on leukaemia. We grouped as (0–14 years), adolescents (15–19 (20–24...
Survival is a key metric of the effectiveness health system in managing cancer. We set out to provide comprehensive examination worldwide variation and trends survival from brain tumors adults, by histology.We analyzed individual data for adults (15-99 years) diagnosed with tumor (ICD-O-3 topography code C71) during 2000-2014, regardless behavior. Data underwent 3-phase quality control as part CONCORD-3. estimated net 11 histology groups, using unbiased nonparametric Pohar Perme...
The present study examined the antinociceptive effect of ethanolic extract from Melissa officinalis L. and rosmarinic acid in chemical behavioral models nociception investigates some mechanisms underlying this effect. (3-1000 mg/kg), given orally (p.o.) 1 h prior to testing, produced dose-dependent inhibition acetic acid-induced visceral pain, with ID50 value 241.9 mg/kg. In formalin test, (30-1000 mg/kg, p.o.) also caused significant both, early (neurogenic pain) late (inflammatory pain),...
A quantitative study was undertaken to assess the plasma and tissue levels, distribution skin (ear) absorption of sesquiterpene α-humulene, main active constituent isolated from plant Cordia verbenacea (Boraginaceae), after oral, intravenous topical administration in mice. The α-humulene levels were quantified by GC-MS analysis. peak concentration achieved 15 min following its oral (150 mg/kg). Then, gradually decreased it almost undetectable at 2 hours 12 administration. When oil C. given...
Abstract Introduction Tumors of the central nervous system are among leading causes cancer-related death in children. Population-based cancer survival reflects overall effectiveness a health care managing cancer. Inequity access to world-wide may result disparities. Methods We considered children (0–14 years) diagnosed with brain tumor during 2000–2014, regardless behavior. Data underwent rigorous, three-phase quality control as part CONCORD-3. implemented revised version International...
Tanacetum parthenium (feverfew) is an herb that commercialized worldwide as a therapeutic treatment for migraine. Its pharmacological effect mainly due to the presence of sesquiterpene lactone parthenolide well flavonoids. So far, there are no studies on standardization pre-formulations or phytomedicines containing this herb. The present study aimed at developing pre-formulation using standardized spray-dried extract feverfew and further designing standardizing enteric coated tablets. In...
In this study, we present a proposal for the physical and chemical quality control of powder species T. parthenium (feverfew) its hydroalcoholic extract obtained by percolation. The sesquiterpene lactone parthenolide, main active compound plant, was quantified HPLC content found to be 0.49% in 1.06% extract. total flavonoids, determined UV spectroscopy, 0.54% 1.05% Santin, flavonoid species, isolated further identified HPLC. Since parthenolide can also other Asteraceae analysis santin is...
Phytochemical study of Mikania hoehnei yielded lupeyl acetate, stigmasterol, b-sitosterol, campesterol, b-sitosteryl glucopyranoside, stigmasteryl benzil 2,6-dimethoxybenzoate, luteolin, kaempferol and two sesquiterpene lactones: dehydrocostuslactone 8b-hydroxyzaluzanin D. IR, ¹H 13C NMR MS spectroscopic analyses comparisons with previously reported data were used for the identification these compounds.
Estudantes do Instituto Federal de Mato Grosso (IFMT) - Campus Rondonópolis propuseram um aplicativo para enfrentar desafios na liberação alunos nos contra-turnos e comunicação com os servidores, visando aprimorar a vida acadêmica. Uma pesquisa realizada revelou dificuldades, como atrasos falta o Núcleo Apoio Psicopedagógico (NAPP). Os resultados indicaram interesse em que permita eficiente solicitação serviços, ressaltando viabilidade projeto necessidade uma solução integrada dos usuários.
Southeastern Brazilian Mikania. (Asteraceae) species were evaluated for trypanocidal activity against the trypomastigote forms of Trypanosoma cruzi.at a concentration 4000 µg/mL. Fourteen extracts examined in vitro. properties. Of total extracts, 92.9% (13 extracts) exhibited effects. The dichloromethane extract Mikania camporum. B. Robinson and methanol micrantha. H. K. caused 100% lysis parasites.
Apresentação do Caso Relatamos o caso paciente CSM, de 29 anos, sexo masculino, que apresentava massa indolor na região perianal havia mais 1 ano, causava incômodo para deambular e sentar, sem drenagem secreção, sangramento ou outros sintomas. Ele procurou atendimento em múltiplos serviços, resolução caso. Ao exame físico, observou-se tumoração próxima a margem anal, posterior direita, aproximadamente 5 cm, fibroelástica, móvel, orifício drenagem. Propôs-se cirurgia ressecção da lesão...