A5042996802- Pain Mechanisms and Treatments
- Acupuncture Treatment Research Studies
- Vagus Nerve Stimulation Research
- Exercise and Physiological Responses
- Musculoskeletal pain and rehabilitation
- Laser Applications in Dentistry and Medicine
- Pharmacological Effects of Natural Compounds
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Healthcare and Venom Research
- Myofascial pain diagnosis and treatment
- Bee Products Chemical Analysis
- Botulinum Toxin and Related Neurological Disorders
- Adipose Tissue and Metabolism
- Asthma and respiratory diseases
- Natural product bioactivities and synthesis
- Complementary and Alternative Medicine Studies
- Stress Responses and Cortisol
- Body Contouring and Surgery
- Nerve injury and regeneration
- Phytochemistry and biological activities of Ficus species
- Neuropeptides and Animal Physiology
- Heart Rate Variability and Autonomic Control
- Biochemical effects in animals
- Phytochemistry Medicinal Plant Applications
- Healthcare Regulation
Universidade Federal de Santa Catarina
2013-2025
Universidade Federal do Pampa
2014-2023
Hospital de Clínicas de Porto Alegre
2022
Universidade Federal de Santa Maria
2021
Universidade do Estado de Santa Catarina
2012
The present study examined the antinociceptive effect of ethanolic extract from Melissa officinalis L. and rosmarinic acid in chemical behavioral models nociception investigates some mechanisms underlying this effect. (3-1000 mg/kg), given orally (p.o.) 1 h prior to testing, produced dose-dependent inhibition acetic acid-induced visceral pain, with ID50 value 241.9 mg/kg. In formalin test, (30-1000 mg/kg, p.o.) also caused significant both, early (neurogenic pain) late (inflammatory pain),...
Abstract Memory, learning, anxiety, and depression have concerned science for years, increasingly leading to research into new therapeutic targets. The study investigated the effect of acupuncture stimulation auricular branch vagus nerve (ABVN) on memory, anxiety-like depression-like behaviors in healthy rats. Healthy rats were divided groups: (1) control, without treatment; (2) left ABVN; (3) right ABVN. Tests conducted evaluate memory (inhibitory avoidance object recognition), (open field,...
In this study, we determined the anti-inflammatory effect of manual acupuncture at Sanyinjiao or Spleen 6 (SP6) point on carrageenan-induced peritonitis in mice and investigated mechanisms that may underlie effect. first set experiments, male Swiss were allocated into five groups: control (sterile saline), dexamethasone (DEXA), invasive sham-acupuncture (non-acupoint), SP6 carrageenan-treated groups. Ten minutes after needle retention 30 min DEXA treatment, received an intraperitoneal...
The present work explored the antinociceptive effects of flavonoid myricitrin in models overt nociception triggered by intraplantar injection chemical algogens into hind paw mice. induced bradykinin (3 nmol/paw i.pl.) was abolished prior treatment with (10-100mg/kg, i.p.) ID(50) 12.4 (8.5-18.1)mg/kg. In sharp contrast, failed to affect elicited prostaglandin E(2) i.pl.). Cinnamaldehyde (10 i.pl.)-induced reduced (100mg/kg, and camphor (7.6 mg/kg,s.c.) 43±10% 57±8%, respectively. Myricitrin...
The 3β, 6β, 16β-trihydroxylup-20(29)-ene (TTHL) is a pentacyclic triterpene obtained from medicinal plant named Combretum leprosum. In folk medicine, this used to treat several diseases associated with inflammation and pain. We previously demonstrated that TTHL presents significant antinociceptive effect, suggesting the involvement of glutamatergic system.This study was designed investigate effect on nociception vascular permeability induced by acetic acid. also evaluated carrageenan-induced...
Neuropathic pain is severely debilitating and resistant to pharmacological approaches; therefore, the study of therapies complement its treatment especially relevant. In a case report study, light-emitting diode therapy (LEDT) has shown analgesic activity as well reduced expression pro-inflammatory cytokines in rabbit osteoarthritis model calcaneal tendinitis rats. Although LEDT stimulated morphofunctional recovery after nerve injury rats, effect against neuropathic not been tested.To that...
Abstract Aim To determine the dose of monosodium iodoacetate (MIA) required to induce oxidative stress, as well pain and edema; confirm induction knee osteoarthritis (OA) symptoms in rats by presence reactive oxygen species (ROS) reduction antioxidant agents; verify histopathological injury these affected joints. Method Biological markers pain, edema, cartilage degeneration provided different doses MIA (0.5; 1.0 or 1.5 mg) rat joints were analyzed. The animal evaluations conducted during 15...
The infusion or decoction of Mirabilis jalapa leaves is used in traditional medicine Brazil to treat inflammatory and painful diseases. Thus, the present study was designed investigate whether leaf ethyl acetate (Eta) fraction from exhibits antinociceptive effect clinically relevant pain models mice. Furthermore, we have investigated role cholinergic system action produced by Eta mice.The administered orally (10mg/kg, p.o.) mice verified on hypersensitivity (mechanical allodynia) chronic...
Although studies have suggested an association between lung infections and increased risk of neuronal disorders (e.g., dementia, cognitive impairment, depressive anxious behaviors), its mechanisms remain unclear. Thus, experimental mice model pulmonary sepsis was developed to investigate the relationship brain inflammation. Male Swiss were randomly assigned either pneumosepsis or control groups. Pneumosepsis induced by intratracheal instillation Klebsiella pneumoniae, while group received a...
Studies have reported that exposure to diesel exhaust particles (DEPs) induces lung inflammation and increases oxidative stress, both effects are susceptible changes via regular aerobic exercise in rehabilitation programs. However, the of on lungs exposed DEP after cessation not clear. Therefore, aim this study was evaluate high-intensity swimming stress mice concomitantly cessation. Male Swiss were divided into 4 groups: Control (n = 12), Swimming (30 min/day) 8), (3 mg/mL-10 μL/mouse) 9)...
Abstract Knee osteoarthritis (OA) is a chronic disease that causes pain and gradual degeneration of the articular cartilage. In this study, MIA‐induced OA knee model was used in rats to test effects photobiomodulation therapy (PBM). We analyzed inflammatory process (pain cytokine levels), its influence on oxidative stress antioxidant capacity. induced by monosodium iodoacetate (MIA) intra‐articular injection (1.5 mg/50 μL) were treated with eight sessions PBM 3 days/week (904 nm, 6 or 18...
Background: Lipopolysaccharide (LPS) endotoxins are activators of innate immunity inducing infection and inflammatory responses. Anti-inflammatory drugs can have undesirable side effects. Acupuncture may be an alternative for the treatment processes. Objective: We investigated potential anti-inflammatory effect manual acupuncture (MA) at SP6 upon LPS-induced peritonitis in rats. Methods: Peritonitis was induced rats with intraperitoneal injection LPS (0.002, 0.02, 0.2 or 2 µg/kg) four...
Abstract Aim To investigate the antinociceptive, antiedematogenic and chondroprotective effects of diacerein (DIA) in a model joint inflammation induced by complete Freund's adjuvant (CFA), as well to involvement metalloproteinase (MMP)‐9, transient receptor potential vanilloid 1 (TRPV1) glial cells DIA′s action mechanism. Methods Complete was injected into knee male rats. We observed mechanical cold hypersensitivity, vocalization spontaneous pain‐related behaviors, edema knee. Tissue...
The present study investigated the mechanisms involved in antinociception produced by triterpene 3β, 6β, 16β-trihydroxylup-20(29)-ene (TTHL) mice. TTHL administered intra-gastric (i.g.) gavage inhibited glutamate-induced nociception with an ID(50) of 19.0 (13.2-27.5) mg/kg. This action started 60 min (inhibition of: 59±6%) after i.g. administration and remained significant up to 6h 37±6%). Moreover, both phases formalin induced pain. was reversed pre-administration naloxone (1mg/kg;...