A5015596805- Sports Performance and Training
- Pain Mechanisms and Treatments
- Sports injuries and prevention
- Ion Channels and Receptors
- Muscle activation and electromyography studies
- Exercise and Physiological Responses
- Infrared Thermography in Medicine
- Laser Applications in Dentistry and Medicine
- Physical Education and Gymnastics
- Spinal Cord Injury Research
- Neuropeptides and Animal Physiology
- Medical research and treatments
- Bee Products Chemical Analysis
- Physical Education and Sports Studies
- Pharmacological Effects of Natural Compounds
- Cerebral Palsy and Movement Disorders
- Children's Physical and Motor Development
- Shoulder Injury and Treatment
- Gout, Hyperuricemia, Uric Acid
- Menstrual Health and Disorders
- Cardiovascular and exercise physiology
- Urticaria and Related Conditions
- Thermoregulation and physiological responses
- Pharmacological Receptor Mechanisms and Effects
- Muscle metabolism and nutrition
Universidade Federal do Amazonas
2016-2025
Universidade Federal de Santa Catarina
2007-2024
Mayo Clinic
2022
WinnMed
2022
Universidade de São Paulo
2017-2020
ORCID
2020
Institute of Pharmacology
2017
Universidade Federal de Santa Maria
2006-2016
Centro Universitário da Cidade
2016
Associação Saúde da Família
2016
Despite intense investigation, the mechanisms of different forms trigeminal neuropathic pain remain substantially unidentified. The transient receptor potential ankyrin 1 channel (encoded by TRPA1 ) has been reported to contribute allodynia or hyperalgesia in some models, including those produced sciatic nerve constriction. However, role and processes that cause pain-like behaviours from insult are poorly understood. TRPA1, monocytes macrophages, oxidative stress behaviour evoked...
Acute gout attacks produce severe joint pain and inflammation associated with monosodium urate (MSU) crystals leading to oxidative stress production. The transient potential receptor ankyrin 1 (TRPA1) is expressed by a subpopulation of peptidergic nociceptors and, via its activation endogenous reactive oxygen species, including hydrogen peroxide (H2O2), contributes neurogenic inflammation. aim this study was investigate the role TRPA1 in hyperalgesia model acute attack rodents. Inflammatory...
Introduction World Para Athletics classifies athletes with brain injury, cerebral palsy, and motor coordination impairments into Group Class 31 to 38. who can run jump but are affected by such as athetosis, ataxia, dystonia, which impact all four limbs the trunk, categorized T36. Monitoring training load performance is essential for guiding programs preventing injuries in this population. Vertical jumps commonly used assess neuromuscular parameters palsy. In study, we tracked changes...
The transient potential vanilloid 1 receptor (TRPV1) is a calcium-permeable channel responsible for the transduction and modulation of acute chronic pain signaling. As such, this target treatment number disorders. However, AMG517, TRPV1 antagonist, presents several clinical limitations that include induction severe hyperthermia. aim study was to investigate possible interaction flavonoid eriodictyol with determine its putative antinociceptive hyperthermic effects. Eriodictyol able displace...
Objective Gout is a common cause of inflammatory arthritis and provoked by the accumulation monosodium urate (MSU) crystals. However, underlying mechanisms pain associated with acute attacks gout are poorly understood. The aim this study was to evaluate role transient receptor potential ankyrin 1 (TRPA‐1) TRPA‐1 stimulants, such as H 2 O , in rodent model MSU‐induced inflammation. Methods MSU or injected into hind paws rodents applied cultured sensory neurons, intracellular calcium response...
The transient receptor potential vanilloid 1 (TRPV1) is relevant to the perception of noxious information and has been studied as a therapeutic target for development new analgesics. goal this study was perform in vivo vitro screens identify novel, efficacious, safe TRPV1 antagonists isolated from leaves medicinal plant Vernonia tweedieana Baker. All fractions hydroalcoholic extract produced antinociception mice during capsaicin test, but dichloromethane fraction also had antioedematogenic...
The treatment with the chemotherapeutic agent paclitaxel produces a painful peripheral neuropathy, and is associated an acute pain syndrome in clinically significant number of patients. However, no standard therapy has been established to manage or chronic neuropathic related paclitaxel. In present study, we evaluated analgesic potential two N-type voltage-gated calcium channel (VGCC) blockers, ω-conotoxin MVIIA Phα1β, on induced by Adult male rats were treated four intraperitoneal...
Herpetic neuralgia is the most important symptom of herpes zoster disease, which caused by <i>Varicella zoster</i>. Nevertheless, pathophysiological mechanisms involved in herpetic are not totally elucidated. Here, we examined neuroimmune interactions at sensory ganglia that account for genesis using a murine model Herpes Simplex Virus Type-1 (HSV-1) infection. The cutaneous HSV-1 infection mice results development zosteriform-like skin lesion followed time-dependent increase pain-like...
There is a major, unmet need for the treatment of cancer pain, and new targets medicines are required. The transient receptor potential ankyrin 1 (TRPA1), cation channel expressed by nociceptors, activated oxidizing substances to mediate pain-like responses in models inflammatory neuropathic pain. As known increase oxidative stress, role TRPA1 was evaluated mouse model Fourteen days after injection B16-F10 murine melanoma cells into plantar region right hind paw, C57BL/6 mice exhibited...
In Southern Brazil, the plant Campomanesia xanthocarpa Berg. (Myrtaceae), popularly known as "guavirova", has been empirically used for its potential effect in reducing blood cholesterol levels. Since there are no scientific data confirming popular use, aim of present study was to investigate on biochemical, hematological, anthropometrical and oxidative stress parameters hypercholesterolemic patients. Thirty three patients were selected according total (TC) levels: 200–240 mg/dL, undesirable...
This study investigated the effects of changing cadence and workload on pedaling technique. Eight cyclists were evaluated during an incremental maximal cycling two 30-minute submaximal trials at 60% 80% power output (W(60%) W(80%), respectively). During trials, they cycled for 10 minutes a freely chosen (FCC), 20% above FCC (FCC+20%), below (FCC-20%). Pedal forces kinematics evaluated. The resultant force (RF), effective (EF), index effectiveness (IE) IE propulsive recovery phase (IEprop...
In a previous work based on popular belief, Campomanesia xanthocarpa Berg., popularly known as “guavirova”, showed to have potential effect in the control of number conditions associated with cardiovascular diseases. The aim present was investigate effects C . extract (CXE) antiplatelet, antithrombotic and fibrinolytic activities mice human blood. Mice were treated orally for 5 days CXE or acetylsalicylic acid at end treatment period animals challenged bleeding, acute thromboembolism...
Gout is characterized by the deposition of monosodium urate (MSU) crystals. Despite being one most painful forms arthritis, gout and mechanisms responsible for its acute attacks are poorly understood. In present study, we found that MSU caused dose-related nociception (ED(50) [ie, necessary dose to elicit 50% response relative control value]=0.04 [95% confidence interval 0.01-0.11]mg/paw) edema (ED(50)=0.08 0.04-0.16]mg/paw) when injected into hind paw rats. Treatment with selective TRPV1...
The aim of the present study was to investigate participation TRPV1 in an acute gout attack model.Experiments were conducted evaluate nociceptive and inflammatory responses (oedema, plasma extravasation, leucocyte infiltration also IL-1β production) triggered by IA (ankle) administration monosodium urate (MSU) rats using selective antagonist receptor, defunctionalization sensory fibres increased immunoreactivity. We have analysed response. mast cells MSU-induced nociception inflammation...
In Brazil, the plant Aloe saponaria Haw, popularly known as "babosa pintadinha", has been empirically used for its potential effect on thermal injury. Because there are no scientific data confirming popular use, aim of present study was to investigate effects nociceptive and inflammatory parameters in a rat model Adult male Wistar rats were subjected injury or sham procedure (immersion water at 70 37 °C, respectively, 5 8 s). Burned animals topically treated with vehicle (base cream),...
Dellagrana, RA, Rossato, M, Sakugawa, RL, Baroni, BM, and Diefenthaeler, F. Photobiomodulation therapy on physiological performance parameters during running tests: Dose-response effects. J Strength Cond Res 32(10): 2807-2815, 2018-This study was aimed at verifying effects of photobiomodulation (PBMT) with different energy doses (15, 30, 60 per site) tests. Fifteen male recreational runners participated in a crossover, randomized, double-blind, placebo-controlled trial. They performed...
Ethnopharmacological relevance: Jatropha isabellei Müll Arg. (Euphorbiaceae) is a medicinal plant that has been used in South American folk medicine for the treatment of arthritic diseases, particularly gout. This study was designed to verify antinociceptive, anti-inflammatory and hypouricemic potential isabellei. Rats were orally administered with crude extract (100–300 mg/kg) or fraction rich alkaloids (0.15 An intra-articular (i.a.) injection 50 μl monosodium urate (MSU) crystals (1.25...