Jaime Shalkow‐Klincovstein
A5053024675- Childhood Cancer Survivors' Quality of Life
- Sarcoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Cardiac tumors and thrombi
- Vascular Malformations and Hemangiomas
- Bone Tumor Diagnosis and Treatments
- Medical Imaging and Pathology Studies
- Palliative Care and End-of-Life Issues
- Renal and related cancers
- Child and Adolescent Health
- Abdominal Surgery and Complications
- Glioma Diagnosis and Treatment
- Testicular diseases and treatments
- Global Cancer Incidence and Screening
- Oral and Maxillofacial Pathology
- Epigenetics and DNA Methylation
- Ethics and Legal Issues in Pediatric Healthcare
- Appendicitis Diagnosis and Management
- Congenital Diaphragmatic Hernia Studies
- Advances in Oncology and Radiotherapy
- Cancer Genomics and Diagnostics
- Neuroblastoma Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Tumors and Oncological Cases
- Chromatin Remodeling and Cancer
Centro Médico ABC
2022-2025
Universidad Anáhuac
2020-2024
Instituto Nacional de Pediatria
2009-2022
Weill Cornell Medical College in Qatar
2022
Cancer Registry of Norway
2021
Queen's University
2018
Cancer Council Queensland
2018
Universidad Autónoma de Nuevo León
2018
Consejo Nacional de Humanidades, Ciencias y Tecnologías
2014-2016
Instituto Nacional de Cancerología
2014
BackgroundLeukaemias comprise a heterogenous group of haematological malignancies. In CONCORD-3, we analysed data for children (aged 0–14 years) and adults 15–99 diagnosed with malignancy during 2000–14 in 61 countries. Here, aimed to examine worldwide trends survival from leukaemia, by age morphology, young patients 0–24 years).MethodsWe 258 population-based cancer registries countries participating CONCORD-3 that submitted on leukaemia. We grouped as (0–14 years), adolescents (15–19 (20–24...
Survival is a key metric of the effectiveness health system in managing cancer. We set out to provide comprehensive examination worldwide variation and trends survival from brain tumors adults, by histology.We analyzed individual data for adults (15-99 years) diagnosed with tumor (ICD-O-3 topography code C71) during 2000-2014, regardless behavior. Data underwent 3-phase quality control as part CONCORD-3. estimated net 11 histology groups, using unbiased nonparametric Pohar Perme...
Pediatric soft tissue sarcomas (STS) are aggressive malignancies with poor prognoses, particularly in recurrent and metastatic cases. Standard therapies, such as cytotoxic chemotherapy, offer limited survival benefits carry significant toxicities, highlighting the urgent need for innovative ther-apeutic approaches. CYP2W1, a tumor-associated monooxygenase enzyme, has emerged promising therapeutic target due to its aberrant expression various cancers; however, role pediatric STS remains...
Pediatric soft-tissue sarcomas (STSs) are aggressive malignancies with poor prognoses, particularly in recurrent and metastatic cases. Standard therapies, such as cytotoxic chemotherapy, offer limited survival benefits carry significant toxicities, underscoring the urgent need for innovative therapeutic approaches. CYP2W1, a tumor-specific monooxygenase enzyme, has emerged promising target due to its aberrant expression various cancers. However, role pediatric STSs remains poorly understood....
Introduction Paediatric burns are a leading cause of mortality among Mexican children, yet comprehensive national data scarce. This retrospective cohort study provides an epidemiological analysis paediatric burn injuries in Mexico using nationwide hospitalisation database. Methods We conducted all patients aged 0–18 years (ICD-10 codes: T200–T329) who were hospitalised the public sector Ministry Health’s hospital discharge database for 2016, 2018 and 2020. used descriptive statistics,...
All the children registered at National Council for Prevention and Treatment of Childhood Cancer were analyzed. The rationale this Federal Government is to financially support treatment all into system. patients are within a network 55 public certified hospitals nationwide.In current study, data from 2007 2012 presented (0-18 years) with pathological diagnosis leukemia, lymphoma solid tumors. parameters analyzed prevalence, incidence, mortality, abandonment rate.A cancer was documented in...
Abstract Background Global variations in survival for brain tumors are very wide when all histological types considered together. Appraisal of international differences should be informed by the distribution histology, but little is known beyond Europe and North America. Methods The source analysis was CONCORD database, a program global surveillance cancer trends, which includes tumor records individual patients from more than 300 population-based registries. We aged 0-99 years who were...
Abstract Background Primary epithelial lung malignancies are rare in childhood and adolescence. We reviewed the Memorial Sloan‐Kettering Cancer Center experience with these tumors to better understand their histology, time diagnosis, treatment, outcome. Procedure A retrospective review was performed on all patients 21 years of age or younger at treated for primary between 1980 2001. Results identified 11 malignancy. The median diagnosis 19 (range: 12–21) years. most common radiographic...
Intratumoral expression of genes encoding Cytochrome P450 enzymes (CYP) might play a critical role not only in cancer development but also the metabolism anticancer drugs. The purpose this study was to compare mRNA patterns seven representative CYPs paired tumor and normal tissue child patients with rabdomyosarcoma (RMS). Using real time quantitative RT-PCR, gene pattern CYP1A1, CYP1A2, CYP1B1, CYP2E1, CYP2W1, CYP3A4, CYP3A5 were analyzed adjacent non-tumor tissues from 13 RMS patients....
Abstract Introduction Tumors of the central nervous system are among leading causes cancer-related death in children. Population-based cancer survival reflects overall effectiveness a health care managing cancer. Inequity access to world-wide may result disparities. Methods We considered children (0–14 years) diagnosed with brain tumor during 2000–2014, regardless behavior. Data underwent rigorous, three-phase quality control as part CONCORD-3. implemented revised version International...
Purpose Limited data describe the delivery of pediatric cancer care in Mexico. We report a nationwide survey units. Methods An electronic was distributed to 74 units Mexico case volumes; organization care; and availability medical/surgical specialists, supportive care, complex therapies, diagnostic services. Centers were classified as low (< 30 new patients/year), medium (30 59/year) high (≥ 60/year). Results Sixty-two centers completed (response rate, 84%). The median annual volume per...
A comprehensive operative report for cancer surgery is crucial accurate disease staging, risk stratification, and therapy escalation/de-escalation, which affects the outcome. Narrative reports may fail to include some critical findings. Furthermore, standardized can form basis of a local registry, often lacking in limited-resource settings (LRSs). In adult literature, synoptic (SOR) contain more key findings than narrative reports. LRSs, where capacity diagnostic pathology services typically...
Abstract Purpose To identify the current practices and priorities in Wilms’ tumor management for surgeons low- middle-income countries (LMICs). Methods One hundred thirty-seven pediatric from 44 completed surveys on Wilms ’ surgical strategy LMIC . This survey was distributed through Global Initiative Children’s Surgery, Pan-African Pediatric Surgical Association, Latin American Oncology Group. Results Ninety-two respondents (67.2%) participated 19 lower (43.2%). Twenty-one (15.3%) nine...
BACKGROUND: Intratumoral up-regulation of genes coding for drug transporters and metabolizing enzymes, such as MDR1 CYP3A4, after chemotherapy are linked to cancer resistance. However their expression in primary soft tissue sarcomas (STS) prior treatment role innate re sistance remain unclear. OBJECTIVE: The aim this study was characterize CYP3A4 pattern before its clinical implication pediatric STS. METHODS: In prospective we analyzed mRNA both normal tumor tissues from 28 newly diagnosed...
The 5-year relative survival rate estimate of treated patients with non-rhabdomyosarcoma soft tissue sarcomas (NRSTS) is ∼50% since they generally present tumor progression, relapse, metastasis, and/or chemoresistance. expression cytochrome P450 (CYP) enzymes in malignancies can affect the pharmacology drugs commonly used chemotherapy or confer susceptibility to development chemical carcinogenesis; addition, their specific be as a therapeutic target. Using qPCR and Western blot assays,...
Introduction. Foreign body aspiration is one of the most common accidents in childhood morbidity and mortality. 3,9 This problem caused, among other reasons by children’s curiosity, immaturity swallowing mechanism anatomical narrowing pathway where foreign bodies become. 4,5,22 Material methods. report describes types objects lodged airway digestive tract; time method extraction, treated at Hospital for Children Toluca, from January 2008 to April 2009. It a cross-sectional, retrospective...
Background. Staging in Hepatoblastoma has recently become controversial. In developing countries diagnosis occurs mostly advanced stages under these circumstances, we propose another option that can be considered of prognostic value. Method. A retrospective analysis cases diagnosed with (HB), treated a single Institution, nine years was conducted. Chemotherapeutic regimens were analyzed, as well the number courses administered and response to treatment. Results. Thirty-two patients studied....
Structural abnormalities of the female reproductive system are manifested in different chronological moments life. 1,5 An imperforate hymen is most common pathology Mullerian duct 1,6 A tentative diagnosis based on a physical examination and imaging studies. The treatment choice plasty (opening hymenal membrane.) 4,25,26 We report five cases who presented hymen. Successful was performed.