A5032035992- Bladder and Urothelial Cancer Treatments
- Urological Disorders and Treatments
- Cancer Immunotherapy and Biomarkers
- Genital Health and Disease
- Urinary and Genital Oncology Studies
- Kidney Stones and Urolithiasis Treatments
- Urologic and reproductive health conditions
- Pediatric Urology and Nephrology Studies
- Prostate Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Ureteral procedures and complications
- Immunotherapy and Immune Responses
- Burn Injury Management and Outcomes
- Cancer Research and Treatments
- Multiple and Secondary Primary Cancers
- Immune Cell Function and Interaction
- Female Genital Mutilation/Cutting Issues
- Tuberous Sclerosis Complex Research
- Rabies epidemiology and control
- Homicide, Infanticide, and Child Abuse
- Ethics in Clinical Research
- MRI in cancer diagnosis
- Pelvic floor disorders treatments
- Urinary Tract Infections Management
- Appendicitis Diagnosis and Management
Stanford Medicine
2025
Weill Cornell Medicine
2024
Cornell University
2024
Stanford University
2024
Rockefeller University
2023-2024
New York Hospital Queens
2024
Presbyterian Hospital
2024
NewYork–Presbyterian Hospital
2024
Universidad Anáhuac
2022-2023
Hospital General de México
2022
Introduction Paediatric burns are a leading cause of mortality among Mexican children, yet comprehensive national data scarce. This retrospective cohort study provides an epidemiological analysis paediatric burn injuries in Mexico using nationwide hospitalisation database. Methods We conducted all patients aged 0–18 years (ICD-10 codes: T200–T329) who were hospitalised the public sector Ministry Health’s hospital discharge database for 2016, 2018 and 2020. used descriptive statistics,...
Abstract Introduction and Objectives: 2141-V11 is a novel anti-CD40 antibody developed by our group, with enhanced binding to FcγRIIB that results in effective tumor-specific T-cell responses vivo recent first-in-human phase I clinical trial (NCT04059588). In several preclinical bladder cancer models, including BCG-unresponsive disease, intravesical administration of durable anti-tumor immunity without systemic toxicity. Based on these findings, we initiated first human Phase I/II study for...
CD40 is a central costimulatory receptor implicated in productive antitumor immune responses across multiple cancers, including bladder cancer. Despite strong preclinical rationale, systemic administration of therapeutic agonistic antibodies targeting the pathway has demonstrated dose-limiting toxicities with minimal clinical activity, emphasizing an important need for optimized CD40-targeted approaches, rational combination therapy strategies. Here, we describe role endogenous IL-15...
Background On encountering a self-inflicted foreign body in the urinary tract, it is common that emergency physicians only consult department of urology, and no further evaluations from other specialties are sought. Psychological conditions can also involve people with psychiatric disorders who perform self-harming or sexual practices. Many case reports bodies have been reported literature. However, there little information regarding which to this situation within (ED). Methodology This...
Wünderlich syndrome (WS) is a spontaneous retroperitoneal hemorrhage confined to the subcapsular or perinephric space without history of trauma. Since it rare condition with significant mortality rate if not treated timely, essential identify its risk factors and early clinical manifestations for favorable outcome. Various conditions are associated, but most common causes benign malignant renal neoplasms. We present 26-year-old female tonic-clonic seizures who presented ED intense abdominal...
To establish the level of access to healthcare, education, social and geographical factors predisposing a negative surgical outcome higher mortality rate in patients with penile cancer.This is retrospective, longitudinal analytical study. Ninety-three medical records adult male diagnosed cancer were reviewed. Fisher's exact test was performed determine association between factors, outcomes for cancer.Patients without primary care had chance having lymphovascular invasion at time diagnosis...
Abstract Introduction: The CD40-CD40L pathway is crucial for activating antigen-presenting cells and initiating tumor-specific T cell responses across various malignancies. However, prior agonistic anti-CD40 antibodies have encountered limited clinical success significant toxicity. Our previous studies demonstrate that interactions between the antibody Fc domain inhibitory Fc-gamma receptor FcγRIIB are critical efficient CD40 multimerization enhanced antitumor activity. To optimize this...
You have accessJournal of UrologyDiversity, Equity & Inclusion: Health Outcomes III (MP70)1 May 2024MP70-17 GLOBAL DISPARITIES IN CLINICAL TRIALS FOR BLADDER CANCER IMMUNE CHECKPOINT INHIBITORS AND ANTIBODY-DRUG CONJUGATES Juan C. Angulo-Lozano, Andres Noyola-Perez, Gabriel Cojuc-Konigsberg, Hector A. Vaquera, Claudia Mendoza, Luisa F. Sanchez, Jimena Alcocer, Pavel S. Pichardo-Rojas, Parwiz Abrahimi, Lina Posada Calderon, LaMont J. Barlow, and Douglas Scherr Angulo-LozanoJuan Angulo-Lozano...
You have accessJournal of UrologyBladder Cancer: Non-invasive I (MP16)1 May 2024MP16-17 PHASE STUDY OF INTRAVESICAL FC-OPTIMIZED ANTI-CD40 AGONIST ANTIBODY 2141-V11 FOR NON-MUSCLE INVASIVE BLADDER CANCER (NMIBC) UNRESPONSIVE TO BACILLUS CALMETTE-GUERIN (BCG) Bernard H. Bochner, Muneeb Alam, Juan C. Osorio, Jeffrey L. Wong, David Knorr, Lucas Blanchard, Angulo-Lozano, Karissa Whiting, Venkatraman E. Seshan, Timothy Donahue, Eugene Cha, Alvin Goh, Robert Smith, Guido Dalbagni, Christian...
Pediatric lower urinary tract symptoms (LUTS) are a set of common childhood problems. Community-level interventions that target behavioral change among children with LUTS can improve outside the clinic environment. Parents, navigating home and school environments, key in supporting healthy bladder behaviors. Thus, we asked parents about their perceptions barriers related to pediatric health.
CD40 is a central co-stimulatory receptor implicated in the development of productive anti-tumor immune responses across multiple cancers, including bladder cancer. Despite strong preclinical rationale, systemic administration therapeutic agonistic antibodies targeting pathway have demonstrated dose limiting toxicities with minimal clinical activity to date, emphasizing an important need for optimized CD40-targeted approaches, rational combination therapy strategies. Here, we describe role...
Background There is a clear association between testicular cancer and microlithiasis when there are predisposing risk factors such as the history of germ cell tumors in first-degree relatives, atrophy, Klinefelter's syndrome, cryptorchidism. This study aimed to establish an histological subtype by analyzing data on Hispanic population. Methods A retrospective cohort, longitudinal, comparative, analytic was conducted patients with confirmed diagnosis primary cancer. The ultrasounds were...