A5042458087- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Global Cancer Incidence and Screening
- Renal cell carcinoma treatment
- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Urological Disorders and Treatments
- Male Reproductive Health Studies
- Urinary Tract Infections Management
- Sexual function and dysfunction studies
- Urologic and reproductive health conditions
- Colorectal Cancer Screening and Detection
- Genital Health and Disease
- Cancer, Lipids, and Metabolism
- Advanced Radiotherapy Techniques
- Molecular Biology Techniques and Applications
- Kidney Stones and Urolithiasis Treatments
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Healthcare Policy and Management
- COVID-19 and healthcare impacts
- Economic and Financial Impacts of Cancer
- Cancer Immunotherapy and Biomarkers
University Hospitals of Cleveland
2020-2025
University School
2020-2025
Case Western Reserve University
2020-2025
Weill Cornell Medicine
2016-2024
Cornell University
2015-2024
New York Hospital Queens
2015-2024
NewYork–Presbyterian Hospital
2015-2024
Presbyterian Hospital
2015-2024
Case Comprehensive Cancer Center
2020-2024
University Hospitals Seidman Cancer Center
2021-2024
Peripheral arterial disease (PAD) affects 5 million people in the US and is primary cause of limb amputations. Exercise remains single best intervention for PAD, part thought to be mediated by increases capillary density. How exercise triggers angiogenesis not known. PPARgamma coactivator (PGC)-1alpha a potent transcriptional co-activator that regulates oxidative metabolism variety tissues. We show here PGC-1alpha mediates exercise-induced angiogenesis. Voluntary induced robust mouse...
The incidence of kidney stones in the United States is currently unknown. Here, we assessed using recent, nationally representative data.We used National Health and Nutrition Examination Survey (NHANES) from 2015 to 2018. During this time participants were asked, "Have you ever had a stone?" "In past 12 months, have passed Demographics analyzed include age, race, gender, body mass index, history smoking, diabetes, hypertension, hypercholesterolemia gout. Multivariable models assess...
In addition to their well-established role as regulators of allergic response, recent evidence supports a for mast cells in influencing the outcome physiologic and pathologic T cell responses. One mechanism by which (MCs) influence function is indirectly through secretion various cytokines. It remains unclear, however, whether MCs can directly activate Ag presentation, expression MHC class II has been controversial. this report, we demonstrate that vitro stimulation mouse with LPS IFN-gamma...
This population-based study assesses the effect of decline in prostate-specific antigen screening and incidence on prostate cancer presentation.
Shoag and colleagues review the long-term results of PSA screening from randomized trials raise questions about whether risk–benefit ratio is as strongly in favor risk over benefit currently gauged. The decline appears to have been precipitated part by misinterpretations data trials.
Abstract Detecting mutations from single DNA molecules is crucial in many fields but challenging. Next-generation sequencing (NGS) affords tremendous throughput cannot directly sequence double-stranded (‘single duplexes’) to discern the true on both strands. Here we present Concatenating Original Duplex for Error Correction (CODEC), which confers duplex resolution NGS. CODEC 1,000-fold higher accuracy than NGS, using up 100-fold fewer reads sequencing. revealed mutation frequencies of 2.72 ×...
BACKGROUND. PI-RADS incorporates rules by which ancillary sequence findings upgrade a dominant score to higher final category. Evidence on the upgrading rules' impact diagnostic pathways remains scarce.
Guidelines from the NCCN® (National Comprehensive Cancer Network®) advocate digital rectal examination screening only in men with elevated prostate specific antigen. We investigated effect of antigen on association and clinically significant cancer a large American cohort.We evaluated records 35,350 who underwent arm Prostate, Lung, Colorectal Ovarian Screening trial for development (Gleason 7 or greater). Followup was 343,273 person-years. The primary outcome rate among vs without...
Prostate-specific antigen screening has profoundly affected the epidemiology of prostate cancer in United States. Persistent racial disparities outcomes for Black men warrant re-examination harms relative to its cancer-specific mortality benefits this population.We estimated overdiagnoses and overtreatment all races 50 84 years age until 2016, most recent year with treatment data available, using excess incidence 1986 based on Surveillance, Epidemiology, End Results registry U.S. Census as...
This cross-sectional study of data from the Surveillance, Epidemiology and End Results database assesses temporal trends in use active surveillance watchful waiting vs definitive treatment men with low- favorable intermediate–risk prostate cancer US between 2010 2018.
Prostate cancer screening by digital rectal examination and prostate specific antigen testing has been routine clinical practice in the United States for last 25 years. Recent studies have shown a national decline following USPSTF (United Preventive Services Task Force) recommendation against screening. However, to our knowledge effect of this on utilization remains unknown.We used NAMCS (National Ambulatory Medical Care Survey) characterize trends rate primary care physicians men older than...
Benign prostatic hyperplasia (BPH), a nonmalignant enlargement of the prostate, is among most common diseases affecting aging men, but underlying molecular features remain poorly understood, and therapeutic options are limited. Here we employ comprehensive investigation BPH, including genomic, transcriptomic epigenetic profiling. We find no evidence neoplastic in BPH: driver genomic alterations, low coding mutation rates, mutational signatures consistent with tissues, minimal copy number...