A5102834208- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Multiple and Secondary Primary Cancers
- Pharmacogenetics and Drug Metabolism
- Medical Malpractice and Liability Issues
- Pharmaceutical studies and practices
- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- COVID-19 and healthcare impacts
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Treatment and Pharmacology
- Telemedicine and Telehealth Implementation
- Hepatocellular Carcinoma Treatment and Prognosis
Michigan Medicine
2022
University of Michigan
2019-2020
AstraZeneca (United States)
2017
Skin cutaneous melanoma is characterized by significant heterogeneity in its molecular, genomic and immunologic features. Whole transcriptome RNA sequencing data from The Cancer Genome Atlas of skin (n = 328) was utilized. CIBERSORT used to identify immune cell type composition, on which unsupervised hierarchical clustering performed. Analysis overall survival performed using Kaplan-Meier estimates multivariate Cox regression analyses. Membership the lymphocyte:monocytelow, monocytehi gh...
Background: Prostate cancer (PCa) is characterized by significant heterogeneity in its molecular, genomic, and immunologic characteristics. Methods: Whole transcriptome RNAseq data from The Cancer Genome Atlas of prostate adenocarcinomas (n = 492) was utilized. immune microenvironment using the CIBERSORTX tool to identify cell type composition. Unsupervised hierarchical clustering performed based on content. Analyses progression-free survival (PFS), distant metastases, overall (OS) were...
Background: Prostate cancer (PCa) is characterized by significant heterogeneity in its molecular, genomic, and immunologic characteristics. Methods: Whole transcriptome RNAseq data from The Cancer Genome Atlas of prostate adenocarcinomas (n=496) was utilized. immune microenvironment using the CIBERSORTX tool to identify cell type composition. Unsupervised hierarchical clustering performed based on content. Analyses progression-free survival (PFS), distant metastases, overall (OS) were...
e15626 Background: Despite recent progress in the treatment of liver cancer, its outcomes remain poor and recurrence rates are as high 70% 5 years. Here we seek to use PD-1 PD-L1 expression characterize tumor immune microenvironment determine whether profile can be associated with response specific treatments applied personalize regimens post-resection setting. Methods: Patients study had a mean age 59, majority were caucasian (73%). Most classified Child-Pugh A (60%) TNM stage 1-2 disease...
Background: Cutaneous Melanoma (SKCM) is characterized by significant heterogeneity in its molecular, genomic, and immunologic characteristics. Methods: Whole transcriptome RNAseq data from The Cancer Genome Atlas of SKCM (n=328) was utilized. immune microenvironment using CIBERSORTX to identify cell type composition. Unsupervised hierarchical clustering performed based on content. Samples were separated into those obtained the primary tumor site regional skin or soft tissue (locoregional),...