A5085382146- Global Cancer Incidence and Screening
- Colorectal Cancer Screening and Detection
- Cervical Cancer and HPV Research
- Economic and Financial Impacts of Cancer
- Advances in Oncology and Radiotherapy
- BRCA gene mutations in cancer
- Genetic factors in colorectal cancer
- Prostate Cancer Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Breast Cancer Treatment Studies
- COVID-19 Pandemic Impacts
- Cancer Risks and Factors
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Pancreatic and Hepatic Oncology Research
- Nanoplatforms for cancer theranostics
- Biopolymer Synthesis and Applications
- Hepatitis C virus research
- Ovarian cancer diagnosis and treatment
- Healthcare Systems and Reforms
- Gallbladder and Bile Duct Disorders
- Acute Lymphoblastic Leukemia research
- Prostate Cancer Treatment and Research
- Lymphoma Diagnosis and Treatment
- Congenital Anomalies and Fetal Surgery
University of Cambridge
2024-2025
National Cancer Registration Service
2020-2025
National Institute for Health Research
2025
African Field Epidemiology Network
2024
National Health Service
2024
Luther University
2024
Martin Luther University Halle-Wittenberg
2024
University of Oxford
2018-2023
American Cancer Society
2018
Université de Yaoundé I
2013
Breast cancer is the leading diagnosis and second most common cause of deaths in sub-Saharan Africa (SSA). Yet, there are few population-level survival data from none on differences by stage at diagnosis. Here, we estimate breast within SSA area, country-level human development index (HDI). We obtained a random sample 2,588 incident cases, diagnosed 2008-2015 14 population-based registries 12 countries (Benin, Cote d'Ivoire, Ethiopia, Kenya, Mali, Mauritius, Mozambique, Namibia, Seychelles,...
Cervical cancer is the second most common and leading cause of death in women sub-Saharan Africa (SSA).
Blood safety remains an issue of major concern in transfusion medicine sub-Saharan Africa. Blood-borne agents such as the human immunodeficiency virus (HIV), hepatitis B (HBV), C (HCV), and Treponema pallidum are among greatest threats to blood for recipient. This study aimed determine seroprevalence risk factors HIV, HCV, HBV, syphilis infections first-time donors at new hospital-based bank Edéa, Cameroon.We carried out a retrospective analysis donor data recorded between December 2011 May...
Breast cancer (BC) is the leading cause of in sub-Saharan Africa (SSA) with rapidly increasing incidence rates reported Uganda and Zimbabwe. However, magnitude these rising trends premenopausal postmenopausal women unknown most African countries. We used data from Cancer Registry Network on incident breast cancers 11 population-based registries 10 countries representing each four SSA regions. explored changes among before after age 50 by calendar period and, where possible, generational...
Abstract Cervical cancer is the leading cause of death in African women. We sought to estimate population‐based survival and evaluate excess hazards for mortality women with cervical cancer, examining effects country‐level Human Development Index (HDI), age stage at diagnosis. selected a random sample 2760 incident cases, diagnosed 2005 2015 from 13 registries 11 countries (Benin, Cote d'Ivoire, Ethiopia, Kenya, Mauritius, Mozambique, Namibia, Seychelles, South Africa, Uganda Zimbabwe)...
BackgroundSecond primary cancers (SPCs) after breast cancer (BC) present an increasing public health burden, with little existing research on socio-demographic, tumour, and treatment effects. We addressed this in the largest BC survivor cohort to date, using a novel linkage of National Disease Registration Service datasets.MethodsThe included 581,403 female 3562 male survivors diagnosed between 1995 2019. estimated standardized incidence ratios (SIRs) for combined site-specific SPCs...
Abstract Background: Prostate cancer is the leading in men sub-Saharan Africa (SSA) regarding incidence and mortality. Published data from a few registries SSA suggest that rates are still rising, but there little comprehensive information on time trends of prostate incidence. Methods: We analyzed registry 13,170 incident cases aged 40 years or above, 12 population-based 11 countries, with at least 10-year span comparable data. Results: observed an increase cumulative risks (CR)...
Trends in the incidence of cancer population Kyadondo County, Uganda-which comprises city Kampala and a peri-urban hinterland-are presented for period 25 years (1991-2015) based on data collected by Cancer Registry. Incidence rates have risen overall-age-adjusted are some 25% higher 2011 to 2015 compared with 1991 1995. The biggest absolute increases been cancers prostate, breast cervix, 100% (prostate), 70% (breast) 45% (cervix) 2010 than There were also esophagus colon-rectum...
The Cancer Survival in Africa, Asia, and South America project (SURVCAN-3) of the International Agency for Research on aims to fill gaps availability population-level cancer survival estimates from countries these regions. Here, we analysed 18 cancers using data member registries African Registry Network across 11 sub-Saharan Africa.
There are limited population-based survival data for colorectal cancer (CRC) in sub-Saharan Africa. Here, 1707 persons diagnosed with CRC from 2005 to 2015 were randomly selected 13 registries operating 11 countries Vital status was ascertained medical charts or through next of kin. 1-, 3- and 5-year overall relative rates all each registry calculated using the Kaplan-Meier estimator. Multivariable analysis used examine associations age at diagnosis, stage country-level Human Development...
This study investigated the determinants of coronavirus disease 2019 (COVID-19) vaccine hesitancy among healthcare workers (HCWs) in Cameroon and Nigeria.This analytic cross-sectional was conducted from May to June 2021, including consenting HCWs aged ≥18 y identified using snowball sampling. Vaccine defined as indecisiveness or unwillingness receive COVID-19 vaccine. Multilevel logistic regression yielded adjusted ORs (aORs) for hesitancy.We included a total 598 (about 60% women)...
To investigate the association between bilateral salpingo-oophorectomy (BSO) and long-term health outcomes in women with a personal history of breast cancer. We used data on diagnosed invasive cancer 1995 2019 from National Cancer Registration Dataset (NCRD) England. The were linked to Hospital Episode Statistics-Admitted Patient Care dataset identify BSO delivery. Long-term selected both datasets. Multivariable Cox regression was examine associations, modelled as time-dependent covariate....
Abstract Background PARP inhibitors are effective in treating ovarian cancer, especially for BRCA1/2 pathogenic variant carriers and those with HRD (homologous recombination deficiency). Concerns over toxicity costs have led to the search predictive biomarkers. We present an updated systematic review, expanding on a previous ESMO review inhibitor Methods Following ESMO’s 2020 protocol, we extended our March 31, 2023, including PubMed clinical trial data. also reviewed reference lists of...
For the last two decades, promoted by many governments and international number in sub-Saharan Africa. In 2005 Cameroon, there were only 60 Community-based health insurance (CBHI) schemes nationwide, covering less than 1% of population. 2006, Cameroon government adopted a national strategy aimed at creating least one CBHI scheme each district 40% population with 2015. Unfortunately, is almost no published data on awareness implementation Cameroon.Structured interviews conducted January 2010...
Cancers occurring in children Africa are often underdiagnosed, or at best diagnosed late. As a result, survival is poor, even for cancers considered 'curable'. With limited population-level data, understanding the actual burden and from childhood difficult. In this study, we aimed providing estimates most common types of affecting aged 0-14 years, three population-based Eastern African registries; Harare, Zimbabwe (Kaposi sarcoma, Wilms tumour (WT), non-Hodgkin lymphoma (NHL),...
Abstract Objectives To estimate observed and relative survival of prostate cancer patients in sub-Saharan Africa (SSA) to examine the influence age, stage at diagnosis Human Development Index (HDI). Patients methods In this comparative registry study, we selected a random sample 1752 incident cases malign prostatic neoplasm from 12 population-based registries 10 SSA countries, registered between 2005 2015. We analyzed data using Kaplan-Meier Ederer II obtain outcome estimates flexible...
Although prostate cancer (PCa) is the most commonly diagnosed in men of sub-Saharan Africa (SSA), little known about its management and survival. The objective current study was to describe presentation, patterns diagnosis, treatment, survival patients with PCa 10 countries SSA.
Abstract Background Cervical cancer (CC) is the most common female in many countries of sub-Saharan Africa (SSA). We assessed treatment guideline adherence and its association with overall survival (OS). Methods Our observational study covered nine population-based registries eight countries: Benin, Ethiopia, Ivory Coast, Kenya, Mali, Mozambique, Uganda, Zimbabwe. Random samples 44–125 patients diagnosed from 2010 to 2016 were selected each. Cancer-directed therapy (CDT) was evaluated for...
Background: Breast cancer (BC) is the most common in sub-Saharan Africa (SSA). However, little known about actual therapy received by women with BC and their survival outcome at population level SSA. This study aims to describe cancer-directed patients SSA, compare these results NCCN Harmonized Guidelines for SSA (NCCN Guidelines), evaluate impact on survival. Methods: Random samples of (≥40 per registry), diagnosed from 2009 through 2015, were drawn 11 urban population–based registries 10...
Background/Purpose Stage at diagnosis is an important metric in treatment and prognosis of cancer, also planning evaluation cancer control. For the latter purposes, data source population-based registry (PBCR), but, although stage usually among variables collected by registries, it often missing, especially low-income settings. Essential TNM has been introduced to facilitate abstraction personnel, but accuracy with which they can do so unknown.
Background: The burden of colorectal cancer (CRC) is increasing in Sub-Saharan Africa (SSA). However, little known about CRC treatment and survival the region. Methods: A random sample 653 patients with diagnosed from 2011 to 2015 was obtained 11 population-based registries SSA. Information on clinical characteristics, treatment, and/or vital status medical records treating hospitals for 356 (54%) (“traced cohort”). Concordance NCCN Harmonized Guidelines SSA assessed. Cox proportional...
Abstract Background Although non-Hodgkin lymphoma (NHL) is the 6th most common malignancy in Sub-Saharan Africa (SSA), little known about its management and outcome. Herein, we examined treatment patterns survival among NHL patients. Methods We obtained a random sample of adult patients diagnosed between 2011 2015 from 11 population-based cancer registries 10 SSA countries. Descriptive statistics for lymphoma-directed therapy (LDT) degree concordance with National Comprehensive Cancer...
Purpose Stage at diagnosis and receipt of therapy are the most important determinants breast cancer (BC) survival in sub-Saharan Africa (SSA). Recently, National Comprehensive Cancer Network guidelines for SSA were published. Our study aimed to describe cancer-directed (CDT) received by patients with BC population level SSA. Methods Random samples (≥ 40 cases per registry) who diagnosed from 2009 2015 drawn 11 population-based registries—Abidjan, Addis Ababa, Bamako, Brazzaville, Bulawayo,...
Abstract Background To assess population-based quality of cancer care in sub-Saharan Africa and to identify specific gaps joint opportunities, we assessed concordance diagnostics treatments with National Comprehensive Cancer Network Harmonized Guidelines for leading types 10 countries. Methods Adult patients female breast cancer, cervical colorectal non-Hodgkin lymphoma, prostate were randomly drawn from 11 registries. Guideline treatment was using clinical records. In a subcohort 906...