A5079200452- Chromatin Remodeling and Cancer
- Glioma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Neuroendocrine Tumor Research Advances
- Cardiac tumors and thrombi
- CNS Lymphoma Diagnosis and Treatment
- Infectious Diseases and Tuberculosis
- Neuroblastoma Research and Treatments
- Colorectal Cancer Screening and Detection
- Tuberculosis Research and Epidemiology
- Cancer therapeutics and mechanisms
- Genetic factors in colorectal cancer
Children's Hospital of Philadelphia
2024-2025
Hospital of the University of Pennsylvania
2024
Centers for Disease Control and Prevention
2021
Emory University
2021
Abstract Background Central nervous system (CNS) tumors lead to cancer-related mortality in children. Genetic ancestry-associated cancer prevalence and outcomes have been studied, but is limited. Methods We performed genetic ancestry prediction 1,452 pediatric patients with paired normal tumor whole genome sequencing from the Open Pediatric Cancer (OpenPedCan) project evaluate influence of reported race ethnicity ancestry-based superpopulations on histology, molecular subtype, survival,...
There are limited population-based survival data for colorectal cancer (CRC) in sub-Saharan Africa. Here, 1707 persons diagnosed with CRC from 2005 to 2015 were randomly selected 13 registries operating 11 countries Vital status was ascertained medical charts or through next of kin. 1-, 3- and 5-year overall relative rates all each registry calculated using the Kaplan-Meier estimator. Multivariable analysis used examine associations age at diagnosis, stage country-level Human Development...
Abstract The addition of rituximab to standard regimens for primary mediastinal large B‐cell lymphoma (PMBCL) has significantly improved overall survival. However, the optimal management isolated central nervous system (CNS) relapse and role CNS prophylaxis remains undefined. We present cases two adolescents with PMBCL who developed relapses. While may be managed high‐dose chemotherapy autologous stem cell transplant or without radiotherapy, review these literature highlight need further...
Abstract Background Central nervous system (CNS) tumors lead to cancer-related mortality in children. Genetic ancestry-associated cancer prevalence and outcomes have been studied, but is limited. Methods We performed genetic ancestry prediction 1,484 pediatric patients with paired normal tumor whole genome sequencing from the Open Pediatric Cancer (OpenPedCan) project evaluate influence of reported race ethnicity ancestry-based superpopulations on histology, molecular subtype, survival,...
Abstract Background In August 2019 the U.S. FDA approved pretomanid as part of a 6-month all-oral BPaL (bedaquiline, pretomanid, and linezolid) regimen for treating pulmonary extensively drug-resistant (XDR) or treatment-intolerant nonresponsive multidrug-resistant (MDR) tuberculosis (TB). study supporting approval, 89% patients had favorable outcome, all reported ≥ 1 adverse event. We describe use in United States. Methods Using 2020 CDC Report Verified Case Tuberculosis (RVCT) MDR TB...