A5010205542- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- Infectious Diseases and Tuberculosis
- Mycobacterium research and diagnosis
- Homelessness and Social Issues
- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- Data-Driven Disease Surveillance
- Diagnosis and treatment of tuberculosis
- Adolescent Sexual and Reproductive Health
- Antimicrobial Resistance in Staphylococcus
- HIV Research and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Syphilis Diagnosis and Treatment
- Hepatitis B Virus Studies
- Pharmaceutical industry and healthcare
- Bacterial Infections and Vaccines
- Amoebic Infections and Treatments
- Parasites and Host Interactions
- Healthcare cost, quality, practices
- Emergency and Acute Care Studies
- COVID-19 epidemiological studies
- COVID-19 Clinical Research Studies
- HIV-related health complications and treatments
Centers for Disease Control and Prevention
2009-2024
Sardar Vallabhbhai National Institute of Technology Surat
2024
The Ohio State University
2023
Michigan Department of Health and Human Services
2023
California Department of Public Health
2023
Arizona Department of Health Services
2023
University of Washington
2023
Public Health – Seattle & King County
2023
National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention
2019-2022
Emory University
2014-2021
Three COVID-19 vaccines are currently approved under a Biologics License Application (BLA) or authorized an Emergency Use Authorization (EUA) by the Food and Drug Administration (FDA) recommended for primary vaccination Advisory Committee on Immunization Practices (ACIP) in United States: 2-dose mRNA-based Pfizer-BioNTech/Comirnaty Moderna single-dose adenovirus vector-based Janssen (Johnson & Johnson) vaccine (1,2) (Box 1). In August 2021, FDA amended EUAs two mRNA to allow additional dose...
On May 5, 2021, CDC's Tuberculosis Trials Consortium and the National Institutes of Health (NIH)-sponsored AIDS Clinical Group (ACTG) published results from a randomized controlled trial indicating that 4-month regimen containing rifapentine (RPT), moxifloxacin (MOX), isoniazid (INH), pyrazinamide (PZA) was as effective standard 6-month for tuberculosis (TB) treatment (1).On basis these findings, CDC recommends option U.S. patients aged ≥12 years with drug-susceptible pulmonary TB provides...
The 2005 CDC guidelines for preventing Mycobacterium tuberculosis transmission in health care settings include recommendations baseline (TB) screening of all U.S. personnel and annual testing working medium-risk or with potential ongoing (1). Using evidence from a systematic review conducted by National Tuberculosis Controllers Association (NTCA)-CDC work group, following methods adapted the Guide to Community Preventive Services (2,3), have been updated now 1) TB an individual risk...
Engagement in care is central to reducing mortality for HIV-infected persons and achieving the White House National AIDS Strategy of 80% viral suppression US by 2020. Where an person lives impacts his or her ability achieve suppression. Reliable transportation access healthcare may be a key determinant this place-suppression relationship.ZIP code tabulation areas (ZCTAs) were units analysis. We used geospatial ecologic analyses examine spatial distributions neighborhood-level variables (eg,...
<h3>Importance</h3> Electronic directly observed therapy (DOT) is used increasingly as an alternative to in-person DOT for monitoring tuberculosis treatment. Evidence supporting its efficacy limited. <h3>Objective</h3> To determine whether electronic can attain a level of treatment observation favorable DOT. <h3>Design, Setting, and Participants</h3> This was 2-period crossover, noninferiority trial with initial randomization or at the time outpatient began. The enrolled 216 participants...
Abstract Background Rifampin-resistant tuberculosis is a leading cause of morbidity worldwide; only one-third persons start treatment, and outcomes are often inadequate. Several trials demonstrate 90% efficacy using an all-oral, 6-month regimen bedaquiline, pretomanid, linezolid (BPaL), but significant toxicity occurred 1200-mg linezolid. After US Food Drug Administration approval in 2019, some clinicians rapidly implemented BPaL initial 600-mg dose adjusted by serum drug concentrations...
Treatment of latent tuberculosis infection (LTBI) is a key component in U.S. control, assisted by recent improvements LTBI diagnostics and therapeutic regimens. Effectiveness therapy, however, limited patients' willingness to both initiate complete treatment. We aimed evaluate the demographic, medical, behavioral, attitude-based, geographic factors associated with treatment initiation completion persons presenting public health clinic.Data for this prospective cohort study were collected...
Objective To determine the feasibility and case detection rate of a geographic information systems (GIS)-based integrated community screening strategy for tuberculosis, syphilis, human immunodeficiency virus (HIV). Design Prospective cross-sectional study all participants presenting to hot spot screenings in Wake County, North Carolina. Methods The residences HIV, syphilis cases incident between 1/1/05–12/31/07 were mapped. Areas with high densities 3 diseases designated “hot spots.”...
In an attempt to curtail the rising morbidity and mortality from undiagnosed HCV (hepatitis C virus) in United States, screening guidelines have been expanded high-risk individuals persons born 1945–1965. Community-based may be one strategy which reach such persons; however, acceptance of testing, when many not access specific medications, remains unknown. We set out assess attitudes about knowledge disease at several community-based testing sites that serve populations. This assessment was...
Abstract The US Food and Drug Administration approved a 6-month regimen of pretomanid, bedaquiline, linezolid for extensively drug-resistant or multidrug-intolerant tuberculosis after trial in South Africa demonstrated 90% effectiveness 6 months posttreatment. We report on patient who completed the using lower dose.
Rationale: More information on risk factors for death from tuberculosis in the United States could help reduce mortality rate, which has remained steady more than a decade.Objective: To identify tuberculosis-related adults.Methods: We performed retrospective study of 1,304 adults with who died before treatment completion and 1,039 frequency-matched control subjects completed 2005 to 2006 13 states reporting 65% U.S. cases. used in-depth record abstractions standard algorithm classify deaths...
ABSTRACT Analysis of a large number HIV-1 genomes at multiple time points after antiretroviral treatment (ART) interruption allows determination the evolution drug-resistant viruses and viral fitness in vivo absence drug selection pressure. Using parallel allele-specific sequencing (PASS) assay, potential primary mutations five individual patients were studied by analyzing over 18,000 genomes. A three-phase was observed termination ART. In first phase, carrying various combinations...
Abstract Background Tuberculosis (TB) causes significant morbidity and mortality in US cities, particularly poor, transient populations. During a TB outbreak Fulton County, Atlanta, GA, we aimed to determine whether local maps created from multiple locations of personal activity per case would differ significantly traditional single residential address. Methods Data were abstracted for patients with disease diagnosed 2008–2014 receiving care at the County Health Department. Clinical location...
This article presents updated recommendations for screening health care workers tuberculosis, including eliminating serial in the absence of exposure or ongoing transmission. May 17, 2019/68(19);439-443 The 2005 CDC guidelines preventing Mycobacterium tuberculosis transmission settings include baseline (TB) all U.S. personnel and annual testing working medium-risk with potential transmission.1Jensen PA Lambert LA Iademarco MF Ridzon R Guidelines health-care settings, 2005.MMWR Recomm Rep....
Little is known about co-occurring tuberculosis (TB) and COVID-19 in low TB incidence settings. We obtained a cross-section of 333 persons the United States co-diagnosed with within 180 days compared them to 4,433 only 2020 18,898 during 2017‒2019. Across both comparison groups, higher proportion TB-COVID-19 were Hispanic, long-term care facility residents, had diabetes. When adjusted for age, underlying conditions, severity, co-infection was not statistically associated death infection...
In 2019, the World Health Organization released guidelines reflecting major changes in multidrug-resistant tuberculosis (MDR-TB) management-prioritizing fluoroquinolones, bedaquiline, and linezolid (LZD) while de-emphasizing previously favored injectable agents. some cases, use is associated with gastrointestinal intolerance, mitochondrial toxicity, significant drug interactions. CDC's Division of Tuberculosis Elimination supports a network regional TB Centers Excellence, which provide...
Chronic helminth infections are common in refugee populations and may persist years after immigration. Asymptomatic Strongyloides stercoralis infection raises particular concern because of its potential for complications immunosuppressed patients. We examined 172 Montagnard refugees resettled to Wake County, North Carolina from 2002 through 2003. Refugees were pretreated with albendazole five days screened health conditions arrival. Eosinophilia was present 41 171 at the first blood draw....
Knowing one's HIV status is particularly important in the setting of recent tuberculosis (TB) exposure. Blood tests for assessment infection, such as QuantiFERON Gold in-tube test (QFT; Cellestis Limited, Carnegie, Victoria, Australia), offer possibility simultaneous screening TB and with a single blood draw. We performed cross-sectional analysis all contacts to highly infectious case large meatpacking factory. Twenty-two percent were foreign-born 73% black. Contacts tested both tuberculin...