A5100646297- Cancer Immunotherapy and Biomarkers
- Global Cancer Incidence and Screening
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Colorectal Cancer Screening and Detection
- Acute Lymphoblastic Leukemia research
- Cervical Cancer and HPV Research
- Childhood Cancer Survivors' Quality of Life
- Advances in Oncology and Radiotherapy
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Economic and Financial Impacts of Cancer
- Circular RNAs in diseases
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Climate change and permafrost
- Rangeland Management and Livestock Ecology
- Glioma Diagnosis and Treatment
- Ideological and Political Education
- Health Systems, Economic Evaluations, Quality of Life
- Bone fractures and treatments
- HER2/EGFR in Cancer Research
- Renal and related cancers
National Cancer Registration Service
2018-2025
African Field Epidemiology Network
2020-2024
Liechtenstein Institute
2024
Hudson Institute
2024
John Wiley & Sons (United States)
2024
Harbin Medical University
2023
Third Affiliated Hospital of Harbin Medical University
2023
Soochow University
2023
Zhejiang Chinese Medical University
2023
Capital Medical University
2023
Breast cancer is the leading diagnosis and second most common cause of deaths in sub-Saharan Africa (SSA). Yet, there are few population-level survival data from none on differences by stage at diagnosis. Here, we estimate breast within SSA area, country-level human development index (HDI). We obtained a random sample 2,588 incident cases, diagnosed 2008-2015 14 population-based registries 12 countries (Benin, Cote d'Ivoire, Ethiopia, Kenya, Mali, Mauritius, Mozambique, Namibia, Seychelles,...
Cervical cancer is the second most common and leading cause of death in women sub-Saharan Africa (SSA).
Abstract Inorganic mercury, though a key component of pediatric vaccines, is an environmental toxicant threatening human health via accumulating oxidative stress in part. Luteolin has been great interest because its antiinflammatory, anticarcinogenic and antioxidative effects. Here we hypothesized that luteolin would attenuate hepatotoxicity induced by acute inorganic mercury exposure. Kunming mice were treated with (100 mg/kg) 24 h after administration 4 mg/kg mercuric chloride (HgCl 2 )....
Breast cancer (BC) is the leading cause of in sub-Saharan Africa (SSA) with rapidly increasing incidence rates reported Uganda and Zimbabwe. However, magnitude these rising trends premenopausal postmenopausal women unknown most African countries. We used data from Cancer Registry Network on incident breast cancers 11 population-based registries 10 countries representing each four SSA regions. explored changes among before after age 50 by calendar period and, where possible, generational...
Abstract Cervical cancer is the leading cause of death in African women. We sought to estimate population‐based survival and evaluate excess hazards for mortality women with cervical cancer, examining effects country‐level Human Development Index (HDI), age stage at diagnosis. selected a random sample 2760 incident cases, diagnosed 2005 2015 from 13 registries 11 countries (Benin, Cote d'Ivoire, Ethiopia, Kenya, Mauritius, Mozambique, Namibia, Seychelles, South Africa, Uganda Zimbabwe)...
The Cancer Survival in Africa, Asia, and South America project (SURVCAN-3) of the International Agency for Research on aims to fill gaps availability population-level cancer survival estimates from countries these regions. Here, we analysed 18 cancers using data member registries African Registry Network across 11 sub-Saharan Africa.
Lead (Pb) is a global environmental health hazard that leads to nephrotoxicity. However, the effective treatment of Pb-induced nephrotoxicity remains elusive. Grape seed procyanidin extract (GSPE) has beneficial properties for multiple biological functions. Therefore, present study investigated whether GSPE reduced as well protective mechanism in well-established 35-day Pb induced rat model. The results showed normalized oxidative stress, histological damage, inflammatory, apoptosis, and...
Abstract Background: Prostate cancer is the leading in men sub-Saharan Africa (SSA) regarding incidence and mortality. Published data from a few registries SSA suggest that rates are still rising, but there little comprehensive information on time trends of prostate incidence. Methods: We analyzed registry 13,170 incident cases aged 40 years or above, 12 population-based 11 countries, with at least 10-year span comparable data. Results: observed an increase cumulative risks (CR)...
Trends in the incidence of cancer population Kyadondo County, Uganda-which comprises city Kampala and a peri-urban hinterland-are presented for period 25 years (1991-2015) based on data collected by Cancer Registry. Incidence rates have risen overall-age-adjusted are some 25% higher 2011 to 2015 compared with 1991 1995. The biggest absolute increases been cancers prostate, breast cervix, 100% (prostate), 70% (breast) 45% (cervix) 2010 than There were also esophagus colon-rectum...
PURPOSE The number of patients with childhood cancer (CC) in sub-Saharan Africa is expected to rise over the coming years. According WHO Initiative for Childhood Cancer, access care crucial and must be guided by needs their families. Our study explored barriers CC treatment from a patient's perspective guide health providers. METHODS From February September 2021, we conducted multinational cross-sectional sample nine population-based registries countries. Inclusion criteria comprised...
There are limited population-based survival data for colorectal cancer (CRC) in sub-Saharan Africa. Here, 1707 persons diagnosed with CRC from 2005 to 2015 were randomly selected 13 registries operating 11 countries Vital status was ascertained medical charts or through next of kin. 1-, 3- and 5-year overall relative rates all each registry calculated using the Kaplan-Meier estimator. Multivariable analysis used examine associations age at diagnosis, stage country-level Human Development...
Scope Increased serum free fatty acid (FFA) occurs in subjects with non-alcoholic liver disease (NAFLD) and also triggers oxidative stress, apoptosis, insulin resistance. Selenium (Se) is an antioxidant agent. However, the effect of Se on NAFLD or diabetes still unclear. We investigated apoptosis abnormal amino metabolism initiated by excess FFA isolated rat hepatocytes. Methods results Primary hepatocytes from rats were exposed to excessive (0.5 mM oleate/palmitic 2:1) 0.1 μM Se. protected...
Cancers occurring in children Africa are often underdiagnosed, or at best diagnosed late. As a result, survival is poor, even for cancers considered 'curable'. With limited population-level data, understanding the actual burden and from childhood difficult. In this study, we aimed providing estimates most common types of affecting aged 0-14 years, three population-based Eastern African registries; Harare, Zimbabwe (Kaposi sarcoma, Wilms tumour (WT), non-Hodgkin lymphoma (NHL),...
Abstract Background and Purpose Conventional MRI is often difficult to distinguish between primary central nervous system lymphomas ( PCNSL s), high‐grade gliomas brain metastases due the similarity of their appearance. The aim this study was investigate whether susceptibility‐weighted imaging SWI ) has higher sensitivity than conventional in detecting hemorrhage s, metastases, can be used differentiate diagnosis these tumors. Methods number lesions with quantified by both MR ....
Abstract Background Pathologists face major challenges in breast cancer diagnostics sub-Saharan Africa (SSA). The problems identified as impairing the quality of pathology reports are shortcomings equipment, organization and insufficiently qualified personnel. In addition, context cancer, immunohistochemistry (IHC) needs to be available for evaluation biomarkers. study presented, we aim describe current state order highlight unmet needs. Methods We obtained information on services within...
Abstract Objectives To estimate observed and relative survival of prostate cancer patients in sub-Saharan Africa (SSA) to examine the influence age, stage at diagnosis Human Development Index (HDI). Patients methods In this comparative registry study, we selected a random sample 1752 incident cases malign prostatic neoplasm from 12 population-based registries 10 SSA countries, registered between 2005 2015. We analyzed data using Kaplan-Meier Ederer II obtain outcome estimates flexible...
Abstract In sub‐Saharan Africa, colorectal cancer (CRC) has historically been considered a rare disease, although some previous studies have suggested that the incidence is increasing. We examine time trends in of CRC using data from 12 population‐based registries 11 countries Africa were able to provide series for periods or more years, with earlier which recent rates may be compared. Age‐standardized highest higher‐income countries, and increasing all populations studied, these increases...
Although prostate cancer (PCa) is the most commonly diagnosed in men of sub-Saharan Africa (SSA), little known about its management and survival. The objective current study was to describe presentation, patterns diagnosis, treatment, survival patients with PCa 10 countries SSA.