Zhigang Zhang

ORCID: 0000-0002-4974-5850
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About
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Research Areas
  • Heavy Metal Exposure and Toxicity
  • Trace Elements in Health
  • Genomics, phytochemicals, and oxidative stress
  • Animal Virus Infections Studies
  • Arsenic contamination and mitigation
  • Retinoids in leukemia and cellular processes
  • Viral gastroenteritis research and epidemiology
  • Insect and Pesticide Research
  • Liver Disease Diagnosis and Treatment
  • Drug-Induced Hepatotoxicity and Protection
  • Viral Infections and Immunology Research
  • Autophagy in Disease and Therapy
  • Selenium in Biological Systems
  • Research in Cotton Cultivation
  • Plant Growth Enhancement Techniques
  • Food Quality and Safety Studies
  • Reproductive Physiology in Livestock
  • Ruminant Nutrition and Digestive Physiology
  • Vitamin C and Antioxidants Research
  • Insect Pest Control Strategies
  • Plant Virus Research Studies
  • Insect Resistance and Genetics
  • Genetic and phenotypic traits in livestock
  • Gut microbiota and health
  • Plant Physiology and Cultivation Studies

Hubei Academy of Agricultural Sciences
2005-2025

Hubei University of Chinese Medicine
2019-2025

Nanjing Normal University
2021-2025

Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application
2022-2025

University of Shanghai for Science and Technology
2025

Peking University
2006-2025

Peking University First Hospital
2006-2025

Zhejiang Ocean University
2024

Northeast Agricultural University
2014-2024

Ministry of Agriculture and Rural Affairs
2022-2024

Exposure to chromium (Cr) causes a number of respiratory diseases, including lung cancer and pulmonary fibrosis.

10.1039/c9fo01152h article EN Food & Function 2019-01-01

Arsenic has been ranked as the most hazardous substance by U.S. Agency for Toxic Substances and Disease Registry. Environmental arsenic exposure-evoked health risks have become a vital public concern worldwide owing to widespread existence of arsenic. Multi-omics is revolutionary technique data analysis providing an integrated view bioinformation comprehensively systematically understanding elaborate mechanism diseases. This study aimed at uncovering potential contribution...

10.1016/j.jare.2024.01.019 article EN cc-by-nc-nd Journal of Advanced Research 2024-01-01

Abstract Inorganic mercury, though a key component of pediatric vaccines, is an environmental toxicant threatening human health via accumulating oxidative stress in part. Luteolin has been great interest because its antiinflammatory, anticarcinogenic and antioxidative effects. Here we hypothesized that luteolin would attenuate hepatotoxicity induced by acute inorganic mercury exposure. Kunming mice were treated with (100 mg/kg) 24 h after administration 4 mg/kg mercuric chloride (HgCl 2 )....

10.1038/srep37157 article EN cc-by Scientific Reports 2016-11-17

Mitochondrial NAD levels influence fuel selection, circadian rhythms, and cell survival under stress. It has alternately been argued that in mammalian mitochondria arises from import of cytosolic nicotinamide (NAM), mononucleotide (NMN), or itself. We provide evidence murine human take up intact NAD. Isolated preparations cannot make NAM, while is synthesized NMN, it does not localize to the mitochondrial matrix effectively support oxidative phosphorylation. Treating cells with riboside...

10.7554/elife.33246 article EN cc-by eLife 2018-06-11

Deltamethrin (DLM) is widely used in agriculture and the prevention of human insect-borne diseases. However, molecular mechanism DLM induced liver injury remains unclear to date. This study investigated potential that fibrosis quails. Japanese quails received resveratrol (500 mg/kg) daily with or without (45 exposure for 12 weeks. Histopathology, transmission electron microscopy, biochemical indexes, TUNEL, quantitative real-time PCR, western blot analysis were performed. hepatic steatosis,...

10.1016/j.ecoenv.2020.111501 article EN cc-by-nc-nd Ecotoxicology and Environmental Safety 2020-11-03

Hexavalent chromium (Cr(VI)), one of the toxic heavy metals, poses a serious threat to human and animal health. Protein acetylation regulates structure function most proteins in variety ways. However, hepatotoxicity Cr(VI) whether it is related deacetylation remains largely unknown.We aimed explore link between silent information regulator two ortholog 1 (Sirt1) induced by exposure, better clarify biological mechanism liver injury Cr(VI).We established model K2Cr2O7 injecting rats...

10.1016/j.jare.2021.04.002 article EN cc-by-nc-nd Journal of Advanced Research 2021-04-08

Deltamethrin (DLM) is a widely used and highly effective insecticide. DLM exposure harmful to animal human. Quail, as bird model, has been in the field of toxicology. However, there little information available literature about quail cerebrum damage caused by DLM. Here, we investigated effect on neurons. Four groups healthy quails were assigned (10 each group), respectively given 0, 15, 30, 45 mg/kg gavage for 12 weeks. Through measurements cerebrum, it was found that induced obvious...

10.1002/tox.23548 article EN Environmental Toxicology 2022-04-21
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