A5056196865- Calcium signaling and nucleotide metabolism
- Sirtuins and Resveratrol in Medicine
- PARP inhibition in cancer therapy
- Biochemical and Molecular Research
- CRISPR and Genetic Engineering
- Carbohydrate Chemistry and Synthesis
- Chemical Synthesis and Analysis
- Nicotinic Acetylcholine Receptors Study
- Bone health and treatments
- Adipose Tissue and Metabolism
- Click Chemistry and Applications
- Vitamin D Research Studies
- DNA Repair Mechanisms
- American and British Literature Analysis
- Muscle Physiology and Disorders
- Cytomegalovirus and herpesvirus research
- Microbial Natural Products and Biosynthesis
- Sulfur-Based Synthesis Techniques
- Diet and metabolism studies
- COVID-19 Clinical Research Studies
- Radiopharmaceutical Chemistry and Applications
- Algal biology and biofuel production
- Contemporary Literature and Criticism
- Carbon Nanotubes in Composites
- Boron Compounds in Chemistry
ChromaDex (United States)
2021
Queen's University Belfast
2008-2018
USA Mitchell Cancer Institute
2017
Queen's University
2015
Highlights•NMN suppresses age-associated body weight gain and enhances energy metabolism•NMN improves insulin sensitivity, eye function, other features with no toxicity•NMN prevents gene expression changes in a tissue-specific manner•NMN is an effective anti-aging intervention that could be translated to humansSummaryNAD+ availability decreases age certain disease conditions. Nicotinamide mononucleotide (NMN), key NAD+ intermediate, has been shown enhance biosynthesis ameliorate various...
Abstract Nicotinamide riboside (NR) is in wide use as an NAD + precursor vitamin. Here we determine the time and dose-dependent effects of NR on blood metabolism humans. We report that human can rise much 2.7-fold with a single oral dose pilot study one individual, elevates mouse hepatic distinct superior pharmacokinetics to those nicotinic acid nicotinamide. further show doses 100, 300 1,000 mg produce increases metabolome first clinical trial also adenine dinucleotide (NAAD), which was not...
Abstract NAD + is a vital redox cofactor and substrate required for activity of various enzyme families, including sirtuins poly(ADP-ribose) polymerases. Supplementation with precursors, such as nicotinamide mononucleotide (NMN) or riboside (NR), protects against metabolic disease, neurodegenerative disorders age-related physiological decline in mammals. Here we show that kinase 1 (NRK1) necessary rate-limiting the use exogenous NR NMN synthesis. Using genetic gain- loss-of-function models,...
ARTD1 (PARP1) is a key enzyme involved in DNA repair through the synthesis of poly(ADP-ribose) (PAR) response to strand breaks, and it plays an important role cell death following excessive damage. ARTD1-induced associated with NAD(+) depletion ATP loss; however, molecular mechanism ARTD1-mediated energy collapse remains elusive. Using real-time metabolic measurements, we compared effects activation direct depletion. We found that PAR synthesis, but not depletion, resulted block glycolysis...
Mitochondrial NAD levels influence fuel selection, circadian rhythms, and cell survival under stress. It has alternately been argued that in mammalian mitochondria arises from import of cytosolic nicotinamide (NAM), mononucleotide (NMN), or itself. We provide evidence murine human take up intact NAD. Isolated preparations cannot make NAM, while is synthesized NMN, it does not localize to the mitochondrial matrix effectively support oxidative phosphorylation. Treating cells with riboside...
Augmenting nicotinamide adenine dinucleotide (NAD+) availability may protect skeletal muscle from age-related metabolic decline. Dietary supplementation of NAD+ precursors mononucleotide (NMN) and riboside (NR) appear efficacious in elevating NAD+. Here we sought to identify the pathways cells utilize synthesize NMN NR provide insight into mechanisms homeostasis. We exploited expression profiling biosynthetic pathways, single double kinase 1/2 (NRK1/2) loss-of-function mice, pharmacological...
Bisphosphonates (BPs) are a class of bone resorptive drug with high affinity for the hydroxyapatite structure matrices that used treatment osteoporosis. However, clinical application is limited by common toxicity, BP-related osteonecrosis jaw. There emerging evidence BPs possess anticancer potential, but exploitation these antiproliferative properties their toxicities. We previously reported utility cationic amphipathic fusogenic peptide, RALA, to traffic anionic nucleic acids into various...
Many natural cyclic peptides have potent and potentially useful biological activities. Their use as therapeutic starting points is often limited by the quantities available, lack of known targets practical limits on diversification to fine-tune their properties. We report enzymes from cyanobactin family heterocyclise macrocyclise chemically synthesised substrates so allow larger-scale syntheses better control over derivatisation. made containing orthogonal reactive groups, azide or...
A range of nucleosides have been synthesised utilising a solventless approach to Vorbrüggen glycosylations aided by mechanochemistry.
Six novel diastereomerically pure C-nucleosides have been synthesized from nonchiral starting materials, using the ene/intramolecular Sakurai cyclization reaction demonstrating a simple, general, and stereocontrolled approach to pyranosyl C-nucleosides.
Benzimidazole-based nucleotides and dinucleotides have been synthesised to increase the range of chemical tools available probe NAD<sup>+</sup> biology space. They were examined for their reactivity in alkylation-type reactions, where they yielded unstable alkylated heteoaromatic adducts, both chemically enzymatically. While unsuited cyclases, these analogues could be viable substrates non-adenine modifying NAD<sup>+</sup>-dependent enzyme classes.
Current debates surrounding canonical literary trauma theor focus on the unutterable nature of traumatic experience adn how this is presented in text. It our contention that critical position marginalises centrality physical body as a marker experience, speaks it endures.
Abstract The synthesis of 2‐deoxy benzamide riboside (XI) proceeds via the preparation m‐vinyl substituted phenyl exo‐alkene key intermediate (VII) which provides necessary flexibility to access m‐carboxamide substituent, essential analogues.