A5073928508- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- Sleep and related disorders
- Pesticide Exposure and Toxicity
- Fibroblast Growth Factor Research
- Tryptophan and brain disorders
- Proteoglycans and glycosaminoglycans research
- Circadian rhythm and melatonin
- Graphene and Nanomaterials Applications
- Trace Elements in Health
- Environmental Toxicology and Ecotoxicology
- Curcumin's Biomedical Applications
- Cancer, Hypoxia, and Metabolism
- Mercury impact and mitigation studies
- Marine Toxins and Detection Methods
- Drug Transport and Resistance Mechanisms
- Glycosylation and Glycoproteins Research
- Sirtuins and Resveratrol in Medicine
- Nanoparticle-Based Drug Delivery
- Epilepsy research and treatment
- Bone Tissue Engineering Materials
- Asthma and respiratory diseases
- Pharmacological Effects and Toxicity Studies
- Viral Infections and Immunology Research
- Pediatric health and respiratory diseases
Jinan University
2009-2024
Zhejiang University
2024
Southern Medical University
2018-2023
Xinjiang Medical University
2020-2023
Northeast Agricultural University
2019-2022
Xiangtan University
2022
Nanfang Hospital
2018
Center of Molecular Immunology (Cuba)
2017
Institute for Biomedicine
2015-2016
Ningxia Medical University
2012
Recently, silver nanoparticles (AgNPs) have been shown to provide a novel approach overcome tumors, especially those of hepatocarcinoma. However, the anticancer mechanism is unclear. Thus, purpose this study was estimate effect AgNPs on proliferation and activation ROS-mediated signaling pathway human hepatocellular carcinoma HePG-2 cells. A simple chemical method for preparing with superior activity has showed in study. were detected by transmission electronic microscopy (TEM) energy...
Hexavalent chromium (Cr(VI)), one of the toxic heavy metals, poses a serious threat to human and animal health. Protein acetylation regulates structure function most proteins in variety ways. However, hepatotoxicity Cr(VI) whether it is related deacetylation remains largely unknown.We aimed explore link between silent information regulator two ortholog 1 (Sirt1) induced by exposure, better clarify biological mechanism liver injury Cr(VI).We established model K2Cr2O7 injecting rats...
Stem cells have generated a great deal of excitement in tissue engineering and regenerative medicine, it is important to understand the interaction mechanisms between nanomaterials mesenchymal stem (MSCs) for biomedical applications. In this study, ruthenium (II) functional selenium nanoparticles (Ru@Se) are used cell research. Specifically, Ru@Se compared with citric acid (Cit@Se)to identify their effects on MSCs differentiation associated molecular mechanism. These data suggest that...
Deltamethrin (DLM) is a widely used and highly effective insecticide. DLM exposure harmful to animal human. Quail, as bird model, has been in the field of toxicology. However, there little information available literature about quail cerebrum damage caused by DLM. Here, we investigated effect on neurons. Four groups healthy quails were assigned (10 each group), respectively given 0, 15, 30, 45 mg/kg gavage for 12 weeks. Through measurements cerebrum, it was found that induced obvious...
Enterovirus 71 (EV71) is the primary causative agent of hand, foot, and mouth disease (HFMD).
Resveratrol (RES) exhibits estrogen-like effects and has potential applications to treatment of osteoporosis caused by estrogen deficiency; however, the specific mechanism action RES remains unclear. Here, we examined therapeutic on ovariectomized (OVX) rats with determined underlying mechanism.We established an OVX rat model study deficiency. The groups were given orally (50, 100, 200 mg/day), group received 0.8 mg/kg E2 daily via oral route, sham-operated control equivalent dose sodium...
Mercury as a toxic heavy metal will accumulate in the body and induce various diseases through food chain. However, it is unknown that detailed mechanism of reproductive disorder induced by inorganic mercury male mice to date. This study investigated toxicological effect mercuric chloride (HgCl2 ) exposure on system mice. Male Kunming received normal saline daily or HgCl2 (3 mg/kg bodyweight) intraperitoneal injection for week. The function was evaluated, decline sperm quality, pregnancy...
Abstract Objectives This study was designed to investigate the cardioprotective effects of matrine on regulation endothelial nitric oxide synthase (eNOS) and asymmetric dimethylarginine (ADMA) in isoproterenol-induced acute myocardial ischaemic rats. Methods Male Sprague–Dawley rats were pretreated with (200, 100 50 mg/kg) orally for 10 days. Acute injury induced by subcutaneous injection isoproterenol. Serum haemodynamic parameters, histopathological variables expression protein levels...
Background : Indoleamine-2,3-dioxygenase 1 (IDO1) is the initial and rate-limiting enzyme in metabolism of tryptophan (TRP) to kynurenine (KYN). IDO1-dependent neurotoxic KYN plays a crucial role pathogenesis many neurodegenerative disorders. However, function IDO1 epilepsy still unclear. Objective In this study, we investigated whether deficiency could affect lithium-pilocarpine-induced model. Methods Patients with controls were enrolled. Male C57BL/6 mice knockout (KO, −/− ) subjected...
Chronic temporal lobe epilepsy (cTLE) is the most common intractable epilepsy. Recent studies have shown that saikosaponin A (SSa) could inhibit epileptiform discharges induced by 4 action potentials and selectively increase transient inactivating K+ currents (IA). However, mechanisms of SSa on IA remain unclear. In this study, we comprehensively evaluated anticonvulsant activities explored whether or not it plays an anti-epileptic role in a Li-pilocarpine rat model via remodeling...
In this report, we describe the high-yield secretory expression of recombinant human anti-HBsAg Fab fragment from Pichia pastoris that was achieved by co-integration genes encoding heavy and light chains (both under control alcohol oxidase promoter) into genome yeast cells. The fed-batch fermentations were carried out in a 5 L scale. Both successfully expressed upon methanol induction. absorbance (OD600) broth can reach 350 approximately 500 at end phase. After induction, level (soluble)...
Abstract Imidacloprid (IMI) is a kind of widely used neonicotinoid insecticide. However, the toxicity IMI not only applied to target pests but also causes serious negative effects on birds and other creatures. Our previous studies have shown that long‐term exposure can induce liver fibrosis in quails. specific mechanism quail induced by completely clear. Accordingly, purpose this study further clarify potential molecular IMI‐induced Japanese quails ( Coturnix japonica ) were treated...
Abstract Objective Resveratrol(RES) is a natural polyphenol which possesses an anti-depressant effect. However, the mechanisms of its effect remain unclear. The aim study to investigate potential in neuro-protective efficiency corticosterone-induced pheochromacytoma 12 (PC12) cells. Methods PC12 cells were treated with 200 μM corticosterone absence or presence different concentrations RES for 24 h. Then, cell viability was measured by Cell Counting Kit-8 assay. Apoptosis Annexin V-FITC and...
The surface chemistry of materials has an interactive influence on cell behavior.