A5103142599- Genomics, phytochemicals, and oxidative stress
- Mesenchymal stem cell research
- Arsenic contamination and mitigation
- Heavy Metal Exposure and Toxicity
- Retinoids in leukemia and cellular processes
- Bone Tissue Engineering Materials
- Trace Elements in Health
- Periodontal Regeneration and Treatments
- Immune Response and Inflammation
- Hematopoietic Stem Cell Transplantation
- Immunotherapy and Immune Responses
- Bone fractures and treatments
- Congenital heart defects research
- Selenium in Biological Systems
- Angiogenesis and VEGF in Cancer
- Orthopaedic implants and arthroplasty
- Tissue Engineering and Regenerative Medicine
- Inflammasome and immune disorders
- Epigenetics and DNA Methylation
- Erythropoietin and Anemia Treatment
- Cardiac Fibrosis and Remodeling
- Genetic Syndromes and Imprinting
- Autophagy in Disease and Therapy
- Infant Nutrition and Health
- Macrophage Migration Inhibitory Factor
Northeast Agricultural University
2010-2024
Air Force Medical University
2017-2022
Xijing Hospital
2017-2022
Dalian Ocean University
2019
Ministry of Agriculture and Rural Affairs
2019
Princess Margaret Cancer Centre
2008-2011
Ludong University
2011
Ontario Institute for Cancer Research
2008
University of Toronto
2008
Niigata University
1997-1998
Arsenic has been ranked as the most hazardous substance by U.S. Agency for Toxic Substances and Disease Registry. Environmental arsenic exposure-evoked health risks have become a vital public concern worldwide owing to widespread existence of arsenic. Multi-omics is revolutionary technique data analysis providing an integrated view bioinformation comprehensively systematically understanding elaborate mechanism diseases. This study aimed at uncovering potential contribution...
Abstract Although bone marrow-derived mesenchymal stromal cells (MSCs) may be beneficial in treating heart disease, their ability to transdifferentiate into functional cardiomyocytes remains unclear. Here, MSCs from adult female transgenic mice expressing green fluorescent protein (GFP) under the control of cardiac-specific α-myosin heavy chain promoter were cocultured with male rat embryonic (rCMs) for 5–15 days. After 5 days coculture, 6.3% became GFP+ and stained positively sarcomeric...
Lead (Pb) is a global environmental health hazard that leads to nephrotoxicity. However, the effective treatment of Pb-induced nephrotoxicity remains elusive. Grape seed procyanidin extract (GSPE) has beneficial properties for multiple biological functions. Therefore, present study investigated whether GSPE reduced as well protective mechanism in well-established 35-day Pb induced rat model. The results showed normalized oxidative stress, histological damage, inflammatory, apoptosis, and...
Lactoferrin, a protein from bovine milk belonging to the transferring family proteins, contains 2 bound Fe(+3) ions. Recent research has revealed that lactoferrin exhibits not only antimicrobial activity by its high affinity for but also remarkable anticancer capacity in cancer cell lines. Meanwhile, increasing evidence suggests aberrant activation of Akt is involved both normal cells and human cancers inhibition signaling pathway might be promising strategy treatment. In present study, we...
Resveratrol (Rev) can ameliorate cytotoxic chemotherapy-induced toxicity and oxidative stress. Arsenic trioxide (As2O3) is a known environmental toxicant potent chemotherapeutic agent. However, the mechanisms by which resveratrol protects liver against effects of As2O3 are not known. Therefore, in present study we investigated involved action using cat model hepatotoxicity was induced means treatment. We found that pretreatment with resveratrol, administered clinically comparable dose...
Arsenic, which causes human carcinogenicity, is ubiquitous in the environment. This study was designed to evaluate modulation of arsenic induced cancer by resveratrol, a phytoalexin found vegetal dietary sources that has antioxidant and chemopreventive properties, trioxide (As2O3)-induced Male Wistar rats.Adult rats received 3 mg/kg As2O3 (intravenous injection, iv.) on alternate days for 4 days. Resveratrol (8 mg/kg) administered (iv.) 1 h before treatment. The plasma homogenization enzymes...
Abstract CD31hiEmcnhi vessels were a subtype of in the murine skeletal system, with high levels platelet and endothelial cell adhesion molecule-1 (PECAM-1/CD31) endomucin (Emcn). They reported coupling angiogenesis osteogenesis during bone development. We investigated distribution these rat tibiae their temporal spatial defect repair process to improve our understanding importance vessels. confirmed that specially distributed around trabecular bones near metaphysis endosteum tibiae. At 3...
Luteolin (Lut) is a natural flavonoid with many biological activities which are ubiquitous in the diet. Renal anemia frequent complication of chronic kidney disease. However, effect Lut on renal not clear to date. This study firstly investigated possible molecular mechanism that protects against mice. Kunming mice received (100 mg/kg) daily or without mercuric chloride (HgCl2) exposure for 16 weeks. Mice from HgCl2 group displayed anemia, interestingly, treatment alleviated it. The results...
Vascularization is one of the most important processes in tissue-engineered bone graft (TEBG)-mediated regeneration large segmental defects. We previously showed that prevascularization TEBGs promoted capillary vessel formation within defected site and accelerated new formation. However, precise mechanisms contribution endogenous cells were not explored. established a defect (5 mm) model femur EGFP+ transgenic rats implanted β-tricalcium phosphate (β-TCP) scaffold seeded with exogenous EGFP−...
Arsenic trioxide (As 2 O 3 ) is a known environmental toxicant and potent chemotherapeutic agent. Significant correlation has been reported between arsenic exposure (including consumption of arsenic-contaminated water clinical use As dysfunction in the nervous system. In this study, we aimed to elucidate effect resveratrol with neuroprotective activities on -induced oxidative damage cerebral cortex injury. Twenty-four healthy Chinese Dragon Li cats either sex were randomly divided into four...
Our previous studies found that sensory nerve tracts implanted in tissue-engineered bone (TEB) could result better osteogenesis. To explore the mechanism of promoting osteogenesis TEB vitro, a transwell coculture experiment was designed between dorsal root ganglion (DRG) cells and marrow mesenchymal stem (BMSCs). BMSC proliferation determined by CCK8 assay, osteo-, chondro-, adipogenic differentiation were assessed alizarin red, alcian blue, oil red staining. We multipotent BMSCs all...
Abstract The prevascularization of tissue-engineered bone grafts (TEBGs) has been shown to accelerate capillary vessel ingrowth in defect remodeling and enhance new formation. However, the exact mechanisms behind this positive effect remain unknown. Here, we report that basic fibroblast growth factor (FGF2)-Ras homolog gene family member A (RhoA)/Rho-associated protein kinase (ROCK) signaling functions as a molecular switch regulate lineage fate mesenchymal stem cells (BMSCs) promotes cell...
Schwann cells have been found to promote osteogenesis by an unclear molecular mechanism. To better understand how accelerate osteogenesis, RNA-Seq and LC-MS/MS were utilized explore the transcriptomic metabolic response of MC3T3-E1 cells. Osteogenic differentiation was determined ALP staining. Lentiviruses constructed alter expression Mif (macrophage migration inhibitory factor) in Western blot (WB) analysis employed detect protein expression. The results this study show that is essential...
Massive bone defects are a challenge in orthopaedic research. Defective regeneration leads to atrophy, non-union of bone, and physical morbidity. Large animals important models, however, production costs high, nursing is complex, evaluation methods limited. A suitable laboratory animal model required explore the underlying molecular mechanism cellular process tissue engineering. We designed stainless steel plate with 8 holes; middle 2 holes were used as guide create standardized critical...
The murine sarcoma cell line MS-K was previously established as a Ki-ras-positive line. Inoculation of this under the flank C3H/HeN mice results in growth large tumors with well-developed blood vessels within day 30 transplantation without any metastasis because cells produce vascular endothelial factor (VEGF). To elucidate role VEGF tumor formation vivo, stable vegf-knockdown-MS-K clones were obtained using plasmid-based knockdown vectors. Interestingly, tumorigenesis completely suppressed...
To investigate the effects of family, stocking density, and their interaction on mortality, growth rate, size dispersal in sea urchin Strongylocentrotus intermedius , 1,440 juveniles from six full‐sib families were exposed to three densities, that is, low density (LD), middle (MD), high (HD), reared for 10 months sea‐based suspended cages. The results demonstrated significant family cumulative mortality rate (CMR); specific test diameter (SGR TD); body weight BW); coefficient variation at...