A5101717330- Antibiotics Pharmacokinetics and Efficacy
- Nanoparticles: synthesis and applications
- Antibiotic Resistance in Bacteria
- Drug Transport and Resistance Mechanisms
- Marine Biology and Environmental Chemistry
- Pregnancy and preeclampsia studies
- Anesthesia and Neurotoxicity Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Selenium in Biological Systems
- Pharmacogenetics and Drug Metabolism
- Aquaculture disease management and microbiota
- Plant Virus Research Studies
- Heavy Metal Exposure and Toxicity
- Liver Disease Diagnosis and Treatment
- Toxin Mechanisms and Immunotoxins
- Environmental Toxicology and Ecotoxicology
- Pancreatic function and diabetes
- Electrochemical sensors and biosensors
- Veterinary medicine and infectious diseases
- Transgenic Plants and Applications
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Phosphorus and nutrient management
- Liver physiology and pathology
- Plant Pathogenic Bacteria Studies
- Tea Polyphenols and Effects
China University of Petroleum, Beijing
2025
Henan University of Science and Technology
2011-2022
Peking University
2016
Peking University People's Hospital
2016
Louisiana State University Agricultural Center
1993
This study aimed to determine whether the challenge from Escherichia coli (E. coli) lipopolysaccharide (LPS) affects pharmacokinetics of danofloxacin in broilers. Twenty 1-day-old Arbor Acres (AA) broilers were equally and randomly divided into 2 groups. When chickens 23, 25, 27, 29 days old, E. LPS (1 mL; 0.5 mg/kg body weight [BW]) sterile saline mL) intraperitoneally injected two After last injection, was given all by gavage at dose 5 BW. Then serum plasma samples each time point...
Abstract The pharmacokinetic profiles of florfenicol ( FF ) or amine FFA in crucian carp were compared at different water temperatures after single intramuscular administration 10 mg/kg bodyweight. concentrations and determined by a high‐performance liquid chromatography method, then, the concentration versus time data subjected to compartmental analysis using one‐compartment open model. At 10, 20, 25°C, peak (C max s) 2.28, 2.29, 2.34 μg/ml, respectively, while those 0.42, 0.71, 0.82...
Luteolin (Lut) is a natural flavonoid with many biological activities which are ubiquitous in the diet. Renal anemia frequent complication of chronic kidney disease. However, effect Lut on renal not clear to date. This study firstly investigated possible molecular mechanism that protects against mice. Kunming mice received (100 mg/kg) daily or without mercuric chloride (HgCl2) exposure for 16 weeks. Mice from HgCl2 group displayed anemia, interestingly, treatment alleviated it. The results...
New enrofloxacin microspheres were formulated, and their physical properties, lung-targeting ability, tissue distribution in rats examined. The had a regular round shape. mean diameter was 10.06 µm, the of 89.93% all ranged from 7.0 µm to 30.0 µm. Tissue evaluated along with conventional preparation after single intravenous injection (7.5 mg enrofloxacin/kg bw). results showed that elimination half-life (t1/2β) lung prolonged 7.94 h for 13.28 microspheres. Area under concentration versus...
BALB/c mice were immunized four times with formalin-prepared abrin-a. Using the polyethylene glycol method, splenocytes isolated and fused SP2/0 cells. An indirect ELISA was established used to detect positive clones secreting monoclonal antibodies (mAbs) against After analysis, three hybridoma IgG-subtype mAbs obtained. The purified from growth medium using protein A or G affinity chromatography. Western blot analysis analyze antigenic epitopes on abrin-a recognized by mAbs. specific for...
Abstract As a semisynthetic tetracycline derivative, doxycycline (α‐6‐deoxy‐5‐hydroxytetracycline) is time‐dependent bacteriostatic agent. It being widely used in the broiler husbandry China. In this study, was orally administered by gavage to 10 healthy chickens at dose of 20 mg/kg body weight every 24 hr for five total treatments. Plasma samples were collected from each animal 5, 10, 20, and 30 min 1, 2, 4, 6, 8, 12 after first dose, 0.25, 0.5, 0.45, 3, 7, 13.5, 24, 36, 48, 60, 72 last...
Abstract Epigallocatechin‐3‐gallate (EGCG) plays a crucial role in hepatic lipid metabolism. However, the underlying regulatory mechanism of metabolism by EGCG canine is unclear. Primary hepatocytes were treated with (0.01, 0.1, or 1 μM) and BML‐275 (an AMP‐activated protein kinase [AMPK] inhibitor) to study effects on gene expressions associated AMPK signaling pathway. Data showed that treatment had greater activation AMPK, as well expression levels transcriptional activity peroxisome...
The pharmacokinetics of orbifloxacin was studied after a single dose (7.5 mg/kg) intravenous or intramuscular administration to crucian carp ( Carassius auratus ) reared in freshwater at 25°C. Plasma samples were collected from six fish per sampling point. Orbifloxacin concentrations determined by high‐performance liquid chromatography with 0.02 μg/ml limit detection, then subjected noncompartmental analysis. After injection, initial concentration 5.83 μg/ml, apparent elimination rate...
The objective of this article is to explore the role imidapril on pulmonary hypertension induced by low ambient temperature in broiler chickens.Ninety chickens were randomly divided into three groups (n = 30): a control group, low-temperature group and an group. Chickens exposed from 14 days age until 45 age; gavaged with 3 mg/kg once daily for 30 days. arterial pressure, main diameter wall thickness measured, lung tissue ACE, ACE2 mRNA expression, proliferating cell nuclear antigen...
To predict the orbifloxacin concentrations in rabbits after multiple routes of administration, a flow‐limited multiroute physiologically based pharmacokinetic (PBPK) model was developed. Three administration ( IV , IM and PO ) were incorporated into this model. Physiological parameters including tissue weights blood flows through different tissues obtained from literature. The tissue/plasma partition coefficients P X s) for noneliminating calculated according to area method, while s kidney...
The pharmacokinetic of minocycline was studied after a single intravenous as well oral dose (5 mg/kg body weight) in crucian carp (Carassius auratus) reared freshwater at 10°C. Plasma samples were randomly collected from six fish each sampling time. concentrations determined by high-performance liquid chromatography and further subjected to noncompartmental analysis. Initial concentration just administration calculated 7.320 μg/ml, while the other parameters injection flows: apparent...
This study was conducted to evaluate the antioxidant capability of dietary supplementation with monoammonium glycyrrhizinate (MAG) in perinatal cows. Glycyrrhizic acid has been shown have strong activity and we hypothesised that aglycone glycyrrhizin MAG, could reduce damage from oxidative stress cows by enhancing capacity. Blood milk samples were collected three groups healthy similar body weight, parity, yield last cycle, etc., receiving MAG ([Day 0 = parturition]: g/day, [n 13)] 3 g/day...