A5100680297- Anesthesia and Neurotoxicity Research
- Bladder and Urothelial Cancer Treatments
- Osteoarthritis Treatment and Mechanisms
- Epigenetics and DNA Methylation
- Neuroscience and Neuropharmacology Research
- Reproductive Biology and Fertility
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Inflammatory mediators and NSAID effects
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Sedative Agents
- Urinary and Genital Oncology Studies
- Autophagy in Disease and Therapy
- Traumatic Brain Injury and Neurovascular Disturbances
- Medical Research and Treatments
- Neuropeptides and Animal Physiology
- Bone Metabolism and Diseases
- Veterinary Pharmacology and Anesthesia
- Circadian rhythm and melatonin
- Neurological Disease Mechanisms and Treatments
- Reproductive Physiology in Livestock
- Genetic factors in colorectal cancer
- Intensive Care Unit Cognitive Disorders
Affiliated Hospital of Guizhou Medical University
2025
Guizhou University
2025
Zhejiang Chinese Medical University
2024-2025
Northeast Agricultural University
2015-2024
Hainan General Hospital
2021-2024
Air Force Medical University
2013-2024
Nanjing Medical University
2013-2024
Jiangsu Province Hospital
2010-2024
Xinqiao Hospital
2019-2024
Hainan Medical University
2021-2024
Angiotensin-(1-7) [Ang-(1-7)] has anti-inflammatory effects in peripheral organs, but its ischaemic stroke are unclear as yet. We investigated whether effect contributes to the neuroprotection induced by Ang-(1-7) a rat model of permanent middle cerebral artery occlusion (pMCAO).We infused Ang-(1-7), Mas receptor antagonist A-779, angiotensin II type 2 PD123319 or artificial CSF into right lateral ventricle male Sprague-Dawley rats from 48 h before onset pMCAO until were killed. Twenty-four...
Periodontitis is initiated and sustained by bacteria. However, the mechanism of bacteria induced periodontitis still unknown. We hypothesized that bacterial components can affect functions stem cells in periodontium. In this study, we comparatively investigated influence Lipopolysaccharide (LPS) on osteogenesis potential human periodontal ligament (PDLSCs) bone marrow mesenchymal (BMMSCs).Human PDLSCs BMMSCs were harvested mineralized nodule formation was assessed alizarin red S staining....
Multiple studies have revealed that repeated or long-term exposure to ketamine causes neurodegeneration and cognitive dysfunction. Pyroptosis is an inflammatory form of programmed cell death has been linked various neurological diseases. However, the role NLRP3/caspase-1 axis-related pyroptosis in ketamine-induced neurotoxicity dysfunction remains uncertain.To evaluate whether caused NLRP3/caspase1-dependent pyroptosis, flow cytometry analysis, western blotting, ELISA test, histopathological...
Cadmium (Cd), as one of the seventh most toxic heavy metal pollutants, widely persisted in environment, leading to osteoblast dysfunction and ultimately Cd-related skeletal disease. However, damaging effects Cd on cellular functions potential pathogenic mechanisms are still unclear. In our study, is believed induce mitochondrial endoplasmic reticulum stress (ERS) a dose-dependent manner, thereby apoptosis, evident by elevated Drp1, Fis1, GRP78, CHOP, ATF4, P-EIF2α, P-PERK, BAX, cleaved...
Dysfunction of myocyte enhancer factor 2D (MEF2D), a key survival protein and transcription factor, underlies the pathogenic loss dopaminergic (DA) neurons in Parkinson's disease (PD). Both genetic factors neurotoxins associated with PD impair MEF2D function vitro animal models PD. We investigated whether distinct stress conditions target via converging mechanisms.We showed that exposure DA neuronal cell line to 6-hyroxydopamine (6-OHDA), which causes animals models, led direct oxidative...
Gestational diabetes mellitus (GDM) is one of the most common medical complications pregnancy, and has important health implications for mother child. Changes in fetoplacental vessels may predict those vasculature developing fetus, as these have been implicated pathogenesis human GDM. This study aimed to determine differences localization expression level VEGFA VEGFR2 between placentas women with GDM normal pregnancies, which first step elucidating possible roles altered uteroplacental...
Abstract The specific adenosine A3 receptor (A3AR) agonist (CF101) has potential for inflammation and pain in various disease, such as arthritis, cancer neuropathic pain, while the role of A3AR post‐traumatic OA underlying mechanism is largely unknown. CF101 was orally administrated rats induced by anterior cruciate ligament transection (ACLT) surgery, rat primary chondrocytes were stimulated hydrogen peroxide (H 2 O , 300 μM). Histologic grading system performed detecting cartilage...
Ovarian aging, a complex and challenging concern within the realm of reproductive medicine, is associated with reduced fertility, menopausal symptoms long-term health risks. Our previous investigation revealed correlation between Peroxiredoxin 4 (PRDX4) human ovarian aging. The purpose this research was to substantiate protective role PRDX4 against aging elucidate underlying molecular mechanism in mice. In study, Prdx4
Background: IgA nephropathy (IgAN) is a leading cause of renal failure, characterized by significant clinical and pathological heterogeneity. Accurate subtype classification remains challenging due to overlapping manifestations the multidimensional nature data. Traditional methods often fail fully capture IgAN’s complexity, limiting their applicability. This study introduces MAL-Net, deep learning framework for multi-label IgAN subtypes, leveraging data incorporating sensor-based inputs such...
With the development of new agricultural business entities in China, a complex competitive evolutionary dynamic has emerged among diversified (abbreviated as ABEs), including farmers (traditional cooperatives, enterprises, and family farms (new ABEs). Based on Lotka–Volterra model, dominance index, Shannon–Wiener index ecological theories, geo-detector, this study examines spatiotemporal evolution driving factors ABEs’ structural changes across 286 Chinese cities from 2012 to 2021. Key...
Gypenosides (GP), the saponin extract derived from Gynostemma pentaphyllum Makino, a widely reputed medicinal plant in China, has been reported to have some neuroprotective effects. We used rat model of chronic cerebral hypoperfusion investigate protective effects GP on cortex and hippocampal CA1 region underlying mechanisms for its inhibition cognitive decline. Daily doses 100 200 mg/kg were orally administered adult male Sprague-Dawley rats 61 days after inducing experimentally, spatial...
Neuroprotection following ischaemic stroke is driven by the interplay between regulatory transcription factors and endogenous protective factors. IRF4, a member of interferon factor (IRF) family, implicated in survival tumour cells. However, its role normal cells including neurons remains elusive. Using genetic approaches, we established central for IRF4 protection against ischaemia/reperfusion (I/R)-induced neuronal death. was expressed neurons, induced stroke. Neuron-specific transgenic...