A5064714503- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Ionic liquids properties and applications
- Chemical and Physical Properties in Aqueous Solutions
- Bone Tissue Engineering Materials
- Thermodynamic properties of mixtures
- RNA Interference and Gene Delivery
- Advanced battery technologies research
- Electrochemical Analysis and Applications
- Graphene and Nanomaterials Applications
- Immunotherapy and Immune Responses
- Supramolecular Self-Assembly in Materials
- Cancer, Hypoxia, and Metabolism
- Mesenchymal stem cell research
- Insect and Pesticide Research
- Peptidase Inhibition and Analysis
- Bladder and Urothelial Cancer Treatments
- Extracellular vesicles in disease
- Effects and risks of endocrine disrupting chemicals
- 3D Printing in Biomedical Research
- Cancer Research and Treatments
- Liver Disease and Transplantation
- Chemical Thermodynamics and Molecular Structure
- Liver Disease Diagnosis and Treatment
- Dental Implant Techniques and Outcomes
University of Electronic Science and Technology of China
2021-2025
Mianyang Central Hospital
2019-2025
Tianjin Hospital
2024-2025
Tianjin Medical University
2024-2025
Changchun Institute of Applied Chemistry
2015-2024
Chinese Academy of Sciences
2015-2024
Zhuhai People's Hospital
2020-2024
Jinan University
2020-2024
Jilin University
2005-2024
Second Affiliated Hospital of Jilin University
2024
Immunogenic cell death (ICD), a manner of tumor that can trigger antitumor immune responses, has received extensive attention as potential synergistic modality for cancer immunotherapy. Although many calcium ion (Ca2+) nanomodulators have been developed therapy through mitochondrial Ca2+ overload, their ICD-inducing properties not explored. Herein, an acid-sensitive PEG-decorated carbonate (CaCO3) nanoparticle incorporating curcumin (CUR; enhancer) (PEGCaCUR) was prepared using simple...
Subcellular organelle-targeted nanoformulations for cancer theranostics are receiving increasing attention owing to their benefits of precise drug delivery, maximized therapeutic index, and reduced off-target side effects. Herein, a multichannel calcium ion (Ca
Chemo-PTT, which combines chemotherapy with photothermal therapy, offers a viable approach for the complete tumor eradication but would likely fail in drug-resistant situations if conventional chemotherapeutic agents are used. Here we show that type of copper (Cu)-palladium (Pd) alloy tetrapod nanoparticles (TNP-1) presents an ideal solution to chemo-PTT challenges. TNP-1 exhibit superior near-infrared conversion efficiency, thanks their special sharp-tip structure, and induce pro-survival...
Various macro/microscopic biomaterials have been developed for controlled drug delivery in the combination therapy of malignancies. However, uncertain loading ratio, release sequence, and spatiotemporal distribution drugs hinder their synergistic therapeutic effects clinical applications. In this work, a tumor microenvironments-adapted composite consisting thermosensitive hydrogel reactive oxygen species (ROS)-responsive nanogel is precisely sequential to enhance molecularly targeted amplify...
Tumor blockade therapy is a promising penetration-independent antitumor modality, which effectively inhibits the exchange of nutrients, oxygen, and information between tumor surrounding microenvironments. However, current strategies have limited efficacy due to defects inadequate obstruction, possible side effects, short duration. For these reasons, facilely synthesized versatile polymer 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-poly(ethylene glycol)-alendronate (DSPE-PEG-ALN, DPA)...
This paper reports measurements of the surface tension ionic liquid EMISE (1-ethyl-3-methylimidazolium ethyl sulfate) using forced bubble method at 278.15 to 323.15 K and densities a Westphal balance 338.15 K. At same time, new theoretical model, interstice is put forward. Applying an expression average volume interstices, v, was obtained. The calculated fraction total interstices 0.12 for in good agreement with that majority materials which exhibit 10∼15% expansion transition from solid...
Osteosarcoma is the most common primary bone cancer and notorious for pulmonary metastasis, representing a major threat to pediatric patients. An effective drug targeting osteosarcoma its lung metastasis urgently needed.In this study, sarcoma-targeting peptide-decorated disulfide-crosslinked polypeptide nanogel (STP-NG) was exploited enhanced intracellular delivery of shikonin (SHK), an extract medicinal herb, inhibit progression with minimal systemic toxicity.The targeted, loaded nanogel,...
Targeted delivery of chemotherapeutic drugs to the desired lesion sites is main objective in malignancy treatment, especially highly metastatic malignancies. However, extensive studies around world on traditional targeting strategies recognizing either overexpressed receptors or microenvironments tumors show great limitations, owing off-target effect and tumor homogeneity. Integration both receptor-mediated (RMT) environment-mediated (EMT) enhances accumulation subsequent cell uptake at same...
Abstract Initially, chemotherapy is effective for treatment of bladder cancer after transurethral resection the bladder. However, certain patients progressively become unresponsive multiple cycles, which results from rapid and almost complete excretion clinically used formulations antineoplastic agents with urinary voiding. Improving mucoadhesiveness penetrability chemotherapeutic drugs are key factors in advanced cancer. Here, a smart disulfide‐crosslinked polypeptide nanogel poly( l...
Absolute temperature sensitivity (Sa) reflects the precision of sensors that belong to same mechanism, whereas relative (Sr) is used compare from different mechanisms. For fluorescence intensity ratio (FIR) thermometry based on two thermally coupled energy levels one rare earth (RE) ion, we define a new as temperature-sensing parameter can vary greatly with in some circumstances, which obtain higher Sa without changing Sr. Further discussion made conditions under these forms parameters be...
With unsatisfactory effects of systemic chemotherapy for treatment unresectable or advanced hepatoma, local and sustained delivery chemotherapeutic agents is becoming a promising solution. The in situ administered platforms increase the drug concentrations tumor regions, decrease side to organs, prevent damage vascular endothelium, reduce frequency administration. prevalent strategy based on minimally invasive transarterial chemoembolization oftentimes induces upper gastrointestinal...
Vascular disrupting agents (VDAs) are emerging anticancer agents, which show rising demand for combination with cytostatic drugs (CSDs), owing to inadequate tumor inhibition when applied singly. Nevertheless, the remains a challenge due different working sites of VDAs and CSDs hypoxia-induced drug resistance after neovasculature by VDAs. Herein, we developed shell-stacked nanoparticle (SNP) coencapsulation VDA combretastatin A-4 phosphate (CA4P) proteasome inhibitor bortezomib (BTZ). The SNP...
The in vivo implanted biomaterials are known to induce inflammatory response and recruit immune cells, which could be used as robust adjuvants for immunotherapy. However, the degree of induced by is hard control. In this work, we reported application three kinds thermogels from polypeptide methoxy poly(ethylene glycol)-polyalanine (mPEG-PAla) with various chiralities regulate levels responses vivo. mPEG-PLAla (EG45LA28) mPEG-PDAal (EG45DA27) exhibited comparable storage modulus ( G') loss...
Nanomaterial-based pancreatic cancer treatment has received widespread attention and rapid development in the past few years. The major challenges include poor combination of diagnosis therapy, difficulty targeting therapy from root unsatisfactory antitumor efficiency, which is accompanied by a great risk relapse metastasis. In this work, positively charged lipid bilayer membrane coated on reduced graphene oxide@gold nanostar (rGO@AuNS) for photoacoustic/photothermal dual-modal...