A5091032296- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Metabolism, Diabetes, and Cancer
- Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Cancer Research and Treatments
- interferon and immune responses
- Phagocytosis and Immune Regulation
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Protease and Inhibitor Mechanisms
- Nanoparticles: synthesis and applications
- Hemodynamic Monitoring and Therapy
- Colorectal Cancer Treatments and Studies
- Inflammasome and immune disorders
- Semiconductor materials and interfaces
- CAR-T cell therapy research
- Cellular Mechanics and Interactions
- Optical Systems and Laser Technology
- Epigenetics and DNA Methylation
- Semiconductor materials and devices
Guangzhou Medical University
2023-2025
First Hospital of Jilin University
2016-2024
Model Animal Research Center
2020-2024
Jilin University
2016-2024
Nanchong Central Hospital
2024
Northeastern University
2020
China Medical University
2009-2019
Ministry of Education of the People's Republic of China
2015
First Hospital of China Medical University
2014
University of Southern California
2013
Various macro/microscopic biomaterials have been developed for controlled drug delivery in the combination therapy of malignancies. However, uncertain loading ratio, release sequence, and spatiotemporal distribution drugs hinder their synergistic therapeutic effects clinical applications. In this work, a tumor microenvironments-adapted composite consisting thermosensitive hydrogel reactive oxygen species (ROS)-responsive nanogel is precisely sequential to enhance molecularly targeted amplify...
In recent years, nanoparticles have been broadly utilized in various drugs delivery formulations. Nanodelivery systems shown promise solving problems associated with the distribution of hydrophobic and promoted accumulation nanomedicines circulation or organs. However, injection dose (NPs) is much greater than that needed by diseased tissues other words, most NPs are localized off-target do not reach desired tissue With rapid development biodegradable biosafety nanomaterials, nanovectors...
CCR9+ T cells have an increased potential to be activated and therefore may mediate strong antitumor responses. Here, we found, however, that CCL25, the only chemokine for cells, is not expressed in human or murine triple-negative breast cancers (TNBCs), raising a hypothesis intratumoral delivery of CCL25 enhance immunotherapy TNBCs. We first determined whether this approach can CD47-targeted using tumor acidity-responsive nanoparticle system (NP-siCD47/CCL25) sequentially release protein...
Abstract The p21-activated kinase 4 (PAK4) is overexpressed in different cancers and promotes proliferation of cancer cells. Reprogramming glucose metabolism found most cells which turn supports rapid proliferation. However, the relationship between PAK4 has not been explored. In this study, we reported that promoted intake, NADPH production lipid biosynthesis, leading to an increased colon Mechanistically, interacted with glucose-6-phosphate dehydrogenase (G6PD), a rate-limiting enzyme...
The androgen receptor (AR) signaling pathway plays a crucial role in the development and growth of prostate malignancies. Regulation AR homeostasis tumorigenesis has not yet been fully characterized. In this study, we demonstrate that p21-activated kinase 6 (PAK6) inhibits by regulating homeostasis. First, demonstrated normal epithelium, co-localizes with PAK6 cytoplasm translocates into nucleus malignant prostate. Furthermore, phosphorylation at Ser-578 promotes AR-E3 ligase murine double...
// Yang Li 1, * , Qiang Ke Yangguang Shao 1 Ge Zhu Yanshu Nanxi Geng Feng Jin 2 Department of Cell Biology, Key Laboratory Ministry Public Health and Medical Education, China University, Shenyang, Breast Surgery, Surgical Oncology, Research Unit General The First Affiliated Hospital These authors have contributed equally to this work Correspondence to: Li, e-mail: fli@mail.cmu.edu.cn Keywords: EMT, cancer, GATA1, PAK5, Phosphorylation Received: October 01, 2014 Accepted: December 21,...
A bioinspired approach was developed for STING agonist delivery with STINGΔTM as a functional carrier.
Immunotherapy has been successfully used in the treatment of multiple malignancies, but clinical studies revealed low response rates. Thus, development new effective immunotherapeutic modalities is urgently needed. Successfully inducing tumor cell death with enhanced antigenicity important for expansion and differentiation tumor-specific CD8+ cytotoxic T lymphocytes. Cationic liposome/DNA complexes (CLN/DNA), which usually have obvious effects, may improve antitumor immunity through...
The posterior intralaminar thalamic nucleus (PIL) and peripeduncular (PP) are two adjoining structures located medioventral to the medial geniculate nucleus. PIL-PP region plays important roles in auditory fear conditioning social, maternal sexual behaviors. Previous studies often lumped PIL PP into single entity, therefore it is not known if they have common and/or different brain-wide connections. In this study, we investigate efferent afferent projections of using reliable anterograde...
As the core area of emotion regulation, amygdala is involved in and regulates many related behaviors, such as fear, anxiety, depression, well reward, learning, memory. Most previous connectional studies have focused on anterior middle parts basolateral nucleus (BL) basomedial (BM) amygdala. Little known about brain-wide connections posterior part BL BM (termed parvicellular subdivision BM, i.e., BLpc BMpc). In this study, afferent efferent projections BMpc rats are investigated using both...
There is a growing need for highly stable system to allow the production of biologics diagnoses and therapeutic interventions on demand that could be used in extreme environments. Among variety biologics, nanobodies (Nbs) derived from single-chain variable antibody fragments camelids have attracted great attention recent years due their small size stability with translational potentials whole-body imaging development new drugs. Intracellular expression using bacterium Escherichia coli has...
Long noncoding RNAs (lncRNAs) have been identified to play important roles in the development and progression of various tumors, including gastric cancer (GC). However, molecular role lncRNAs GC remains unclear.To investigate differential expression human elucidate function regulatory mechanism LINC02407.The Cancer Genome Atlas database was used involvement GC. Quantitative real-time polymerase chain reaction estimate relative level LINC02407 tissues cells. Functional experiments CCK8 assay,...
We studied the effects of dietary astragalus polysaccharides on cellular immune response yellow catfish (Pelteobagrus fulvidraco). 540 Yellow were fed different levels (0, 300, 600, 900, 1200, or 1500 mg/kg diet) for eight weeks. Non-specific responses measured at end experimental feeding. then challenged control and treated fish with an intraperitoneal injection Aeromonas hydrophila recorded mortality seven days. Groups 1200 displayed a significant increase in oxygen respiratory burst...
The antibacterial activity of five medicinal herbs, alone and together with other herbs or one six antibiotics, against Edwardsiella tarda was determined by World Health Organization-International Collaborative Study (WHO-ICS) agar dilution protocol. Minimal inhibitory concentrations (MIC) the were significantly lower (≤4 mg/ml) in treatments using combinations Rhizoma coptidis+Radix scutellariae, Galla chinensis+Radix et rhei, Radix rhei+Radix scutellariae than coptidis, Flos lonicerae (≥32...
Abstract Cancer immunotherapy is to artificially stimulate the immune system against tumor cells. Effectively increasing immunogenicity of dying cells has great potential anticancer responses. Recently, a synthetic cationic polypeptide (ACPP) prepared, which mimics host defense peptides, effectively inhibit growth by directly inducing rapid necrosis cancer through membrane‐lytic mechanism. Thus, this ACPP ability induce immunogenic cell death (ICD) and promote antitumor immunity. Herein, it...
To improve the biosafety of nanodelivery system, this study developed novel monodisperse spherical aluminum nanoparticles (Al NPs) and evaluated their cytotoxicity in vitro distribution biotoxicity vivo. Compared with gold same size, Al NPs not only had low but also did cause accumulation major organs vivo after intravenous injections. No significant abnormalities were observed serum biochemical indices mice injected NPs. Additionally, no substantial changes occurred histopathology organs,...