A5101790091- Mycotoxins in Agriculture and Food
- Pharmacological Effects of Natural Compounds
- Liver Disease Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Lymphoma Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Immune Cell Function and Interaction
- Natural product bioactivities and synthesis
- Tea Polyphenols and Effects
- Chronic Lymphocytic Leukemia Research
- Adipose Tissue and Metabolism
- NF-κB Signaling Pathways
- Diet, Metabolism, and Disease
- Reproductive Physiology in Livestock
- Lung Cancer Treatments and Mutations
- Healthcare and Venom Research
- Animal Nutrition and Physiology
- Protein Hydrolysis and Bioactive Peptides
- RNA modifications and cancer
- Traditional Chinese Medicine Analysis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Peroxisome Proliferator-Activated Receptors
- Cardiac Ischemia and Reperfusion
- Food Allergy and Anaphylaxis Research
- Sirtuins and Resveratrol in Medicine
Anhui Agricultural University
2015-2024
Sichuan University
2009-2024
Duke Medical Center
2024
West China Hospital of Sichuan University
2009-2024
Dalian University of Technology
2024
Hubei University of Medicine
2017-2023
Taihe Hospital
2017-2023
Guangxi Medical University
2023
Guangxi University
2023
Shihezi University
2021-2023
Observe the protective effect of chlorogenic acid on dextran sulfate-induced ulcerative colitis in mice and explore regulation MAPK/ERK/JNK signaling pathway.Seventy C57BL/6 (half males half females) were randomly divided into 7 groups, 10 each group: control group (CON group), UC model (UC sulfasalazine-positive (SASP low dose (CGA-L medium (CGA-M high (CGA-H ERK inhibitor + (E+CGA group). The effects evaluated by colon mucosa damage index (CMDI), HE staining, immunohistochemistry, ELISA,...
The prognosis of leptomeningeal metastasis (LM) from solid tumors is extremely poor, especially for patients with adverse prognostic factors. In this phase II clinical trial, we evaluated the efficacy and safety intrathecal chemotherapy (IC) combined concomitant involved‐field radiotherapy (IF‐RT) treating LM Fifty‐nine various were enrolled between May 2010 December 2014. Concurrent therapy consisted IC (methotrexate 12.5–15 mg dexamethasone 5 mg, weekly) IF‐RT (whole brain and/or spinal...
The liver X receptors (LXRs), members of the nuclear receptor superfamily, play an important role in controlling lipid homeostasis by activating several genes involved reverse cholesterol transport. These include ATP binding cassette (ABC) superfamily transporter proteins ABCA1 and ABCG1, surface constituents plasma lipoproteins like apolipoprotein E, ester transport protein. They also fatty acid metabolism sterol regulatory element-binding protein 1c gene. Here, we identify human LXRalpha...
White striping (WS) and woody breast (WB) are 2 of the major myopathies in modern poultry industry. Even though exact etiology for WS WB is still unknown, differentially expressed genes broiler muscle affected by indicate that oxidative stress inflammation could be involved their occurrences. Therefore, it very important to identify natural compounds with anti-oxidative anti-inflammation properties can reduce occurrences chickens. Rutin a polyphenol antioxidant has been reported present...
Elevated plasma nonesterified fatty acid (NEFA) levels and hepatocytes damage are characteristics of ketosis in dairy cows. Oxidative stress is associated with the pathogenesis NEFA-induced liver damage. However, exact mechanism by which oxidative mediates apoptosis injury remains poorly understood. The results present study demonstrated that NEFA contribute to reactive oxygen species (ROS) generation, resulting an imbalance between antioxidant species, transcriptional activation p53,...
β-Conglycinin (7S) and glycinin (11S) are known to induce a variety of hypersensitivity reactions involving the skin, intestinal tract, respiratory tract. The present study aimed identify mechanism underlying development allergy soybean antigen proteins, using piglets as an animal model. Weaned "Duroc × Landrace Yorkshire" were fed diet supplemented with 7S or 11S investigate signaling pathway involved in damage piglets. Results showed that serum nitric oxide (NO), tumor necrosis factor-α...
Berberine hydrochloride is an isoquinoline type alkaloid extracted from Berberidaceae, Rutaceae, and other plants. Previous reports have shown that berberine has anti‐inflammatory properties. However, the underlying molecular mechanisms remain unclear. In this study, a lipopolysaccharide‐ (LPS‐) induced murine model of mastitis was established to explore action hydrochloride. Sixty mice had been lactating for 5–7 days were randomly divided into six groups, including control, LPS, three...
Abstract Background Tea polyphenols (TPs) attenuate obesity related liver inflammation; however, the anti-obesity effects and anti-inflammatory mechanisms are not clearly understood. This study aimed to determine whether TPs associated with cyclooxygenase-2 (COX-2) inducible nitric oxide synthase (iNOS) expression levels, obesity-related gene response in dogs. Results Dogs fed displayed significantly decreased ( p < 0.01) mRNA of tumor necrosis factor-α (TNF-α), interleukin-1 beta...
Purpose: COVID-19 has had a huge impact on the physical behavior and mental health of people. Long-term strict isolation policies are widely used to ensure social distancing, which may cause excessive smartphone use increase risk addiction. Previous researchers have identified that some factors affect addiction, but there was little research conducted during pandemic. The present study aims examine effect peer phubbing how boredom proneness mediate this effect, lastly refusal self-efficacy...
BACKGROUND: Approximately half of the patients with acute ischemic stroke who receive intravenous thrombolysis (IVT) do not achieve an excellent outcome. Remote conditioning (RIC) as a promising neuroprotective treatment may improve clinical outcomes in this population. This study aimed to assess efficacy and safety RIC IVT. METHODS: multicenter, participant-blinded, blinded end point, randomized controlled trial included 558 underwent IVT 18 hospitals from August 2021 May 2023. After IVT,...
<title>Abstract</title> Radiotherapy (RT) combined with chemotherapy is the standard treatment for newly diagnosed glioblastoma (GBM). However, limited RT efficacy and RT-related cancer resistance have spurred interest in radiosensitizing strategies of GBM. We aimed to explore synergistic BRD4 inhibitor I-BET151 combination GBM therapy. found upregulated after was correlated radiosensitivity. sensitized cells by inhibiting cell proliferation, inducing apoptosis, thus prolonging survival...
The objective of the present study was to elucidate mechanism underlying liver metabolic perturbations in dairy cows exposed heat stress (HS).Liquid chromatography massabl spectrometry used analyze differences livers 20 cows, with and without exposure HS.The results revealed 33 potential metabolite candidate biomarkers for detection HS cows. Fifteen these metabolites (glucose, lactate, pyruvate, acetoacetate, β-hydroxybutyrate, fumaric acid, citric choline, glycine, proline, isoleucine,...
Deoxynivalenol (DON) is highly toxic to animals and humans, but pigs are most sensitive it. The porcine mucosal injury related mechanism of DON not yet fully clarified. Here, we investigated DON-induced in the intestinal tissues piglet. Thirty weanling piglets [(Duroc × Landrace) Yorkshire] were randomly divided into three groups according single factor experimental design (10 each group). Piglets fed a basal diet control group, while low high dose (1300 2200 μg/kg, respectively) for 60...
The aim of this study was to investigate the effects deoxynivalenol (DON) exposure on inflammatory injury nuclear factor kappa-B (NF-κB) pathway in intestinal epithelial cells (IPEC-J2 cells) pig. different concentrations DON (0, 125, 250, 500, 1000, 2000 ng/mL) were added culture solution for treatment. NF-κB inhibitor pyrrolidine dithiocarbamate (PDTC) used as a reference. results showed that when concentration increased, cell density decreased and seemed damaged. With increase medium,...
Indirubin and isatin have been used in the treatment of inflammatory diseases due to their anti-inflammatory properties. This study aimed evaluate combined effect indirubin on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC). UC was induced by administration 3% (w/v) DSS solution, then model mice were administered (10 mg/kg body mass) (or) gavage once daily for 7 days. The results showed that isatin, individually or combined, significantly inhibited weight loss, lowered disease...