A5101646456- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Stroke Rehabilitation and Recovery
- Blood Coagulation and Thrombosis Mechanisms
- Inflammatory Biomarkers in Disease Prognosis
- Cardiac Ischemia and Reperfusion
- Neurological Disorders and Treatments
- Cardiac Imaging and Diagnostics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Intracranial Aneurysms: Treatment and Complications
- Genetic Neurodegenerative Diseases
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurosurgical Procedures and Complications
- Cerebral Venous Sinus Thrombosis
- Atrial Fibrillation Management and Outcomes
- Cardiovascular and Diving-Related Complications
- Neurological Disease Mechanisms and Treatments
- Neurological Complications and Syndromes
- Advanced MRI Techniques and Applications
- Blood Pressure and Hypertension Studies
- Autophagy in Disease and Therapy
First Hospital of Jilin University
2016-2025
Jilin University
2016-2025
The First Affiliated Hospital, Sun Yat-sen University
2013-2025
Zhongshan Hospital
2010-2025
Fudan University
2013-2025
Sun Yat-sen University
2013-2025
Huaiyin Institute of Technology
2020-2021
Chinese Academy of Sciences
2019
Academia Sinica
2019
Weatherford College
2019
Backgrounds. The prevalence of diabetes has increased with the increase obesity, and finding indicators to predict risk become an urgent need. purpose this study is compare correlation between four anthropometric indices diabetes. Methods. A total 4052 participants aged 40 years above were selected in Dehui City, Jilin Province, using a multistage stratified whole group sampling method. Face-to-face interviews physical examinations conducted. Multivariate logistic analysis was used. values...
To determine the effect of remote ischemic preconditioning (RIPC) on dynamic cerebral autoregulation (dCA) and various blood biomarkers in healthy adults.A self-controlled interventional study was conducted. Serial measurements dCA were performed at 7 time points (7, 9, 11 am; 2, 5, 8 pm, am next day) without or with RIPC, carried out 7:20 to am. Venous samples collected baseline (7 am) 1 hour after biomarkers, including 5 neuroprotective factors 25 inflammation-related measured a...
Stroke of large-artery atherosclerosis and small-artery occlusion are two main subtypes stroke according to TOAST classification. The underlying mechanisms how these affect dynamic cerebral autoregulation (dCA) might be heterogeneous, resulting in varied clinical conditions outcomes. We therefore studied the pattern dCA subtypes.Forty-one patients with acute unilateral middle artery (MCA) territory (15 ipsilateral 26 occlusion) 20 healthy volunteers were enrolled. Non-invasive continuous...
BACKGROUND: Approximately half of the patients with acute ischemic stroke who receive intravenous thrombolysis (IVT) do not achieve an excellent outcome. Remote conditioning (RIC) as a promising neuroprotective treatment may improve clinical outcomes in this population. This study aimed to assess efficacy and safety RIC IVT. METHODS: multicenter, participant-blinded, blinded end point, randomized controlled trial included 558 underwent IVT 18 hospitals from August 2021 May 2023. After IVT,...
There is little data about the prognostic value of mitral annular dilatation (MAD) in patients with symptomatic severe aortic regurgitation (AR) undergoing transcatheter valve replacement (TAVR). This study aimed to assess prognosis computed tomography (CT)-determined MAD such patients. Consecutive AR who underwent pre-TAVR CT between May 2014 and 2023 were included this study. The clinical endpoint was composite outcome all-cause death heart-failure hospitalization. Mitral dimensions...
To investigate the characteristics of dynamic cerebral autoregulation (dCA) in patients after mechanical thrombectomy (MT) and relationship between dCA prognosis. In this prospective study, 89 158 were enrolled MT non-MT groups, respectively. Both groups underwent measurements within 3 days stroke. The transfer function parameter, phase difference (PD), gain used to quantify dCA. A favorable outcome was defined as a modified Rankin Scale score ≤ 2 at 90 days. collateral reflect reserve...
Evidence suggests that the protease-activated receptor-1 (PAR-1), a thrombin receptor, mediates neuronal injury in experimental cerebral ischemia. The present study investigated whether PAR-1 plays role brain after global ischemia.Adult male wild-type or knockout mice underwent 20-minute bilateral common carotid artery occlusion sham operation. Behavior tests were performed before ischemia and 1, 2, 3 days occlusion. Mice euthanized at different time points for activity, edema, Western blot...
The objective of this study was to investigate the safety and efficacy remote ischemic conditioning (RIC) combined with intravenous thrombolysis (IVT) in treatment acute stroke (AIS).Patients AIS who underwent IVT were enrolled 1:1 randomized RIC group sham-RIC study. (or sham-RIC) performed twice within 6-24 h IVT. subjects two groups followed up for 90 days. outcome included ratio hemorrhagic transformation (HT), adverse events during follow-up, blood pressure first 24 after IVT,...
Background The changes in the platelet-to-lymphocyte ratio (PLR) before and after recombinant tissue plasminogen activator (rtPA) treatment time point at which PLR is a potentially valuable prognostic predictor patients wit ischemic stroke remain largely unknown. Therefore, purpose of this study was to explore characteristics evaluate their effects on clinical outcomes 24 h rtPA treatment. Methods This included 741 consecutive with acute who underwent intravenous thrombolysis rtPA. We...
Finding appropriate drugs to improve cerebral autoregulation (CA) in patients with acute ischemic stroke (AIS) is necessary prognosis. We aimed investigate the effect of butylphthalide on CA AIS. In this randomized controlled trial, 99 were 2:1 or placebo group. The group received intravenous infusion a preconfigured butylphthalide-sodium chloride solution for 14 days and an oral capsule additional 76 days. synchronously 100 mL 0.9% saline simulation capsule. transfer function parameter,...
Background The study aimed to investigate the relationship between uric acid (UA) levels and functional outcomes at 3 months in patients with acute ischemic stroke (AIS) who underwent intravenous thrombolysis (IVT). Methods Results This prospective cohort included 1001 consecutive AIS IVT. correlation UA post‐IVT was examined. Any nonlinear assessed using a restricted cubic spline function. P value for association of favorable (modified Rankin Scale [mRS] score ≤2) excellent (mRS ≤1) were...
Background and Purpose The relationship between right-to-left shunts (RLS) migraine cryptogenic stroke is not well understood. In this study, we investigated whether RLS are associated with impairment of dynamic cerebral autoregulation (dCA), which may play a role in stroke. Methods Sixty-six migraineurs were enrolled the including 36 non-RLS patients 30 patients. Non-invasive continuous blood flow velocity arterial pressure recorded simultaneously from each patient by using transcranial...
Objective We aimed to investigate the value of three-dimensional (3D) T1 volumetric isotropic turbo spin echo acquisition (VISTA) in diagnosis cervical artery dissection (CAD). Methods prospectively included patients who were suspected as having a CAD within 1 month onset. For VISTA, was based on presence intramural high-signal, intimal flap, double lumen and aneurysmal dilation. The final clinical history, physical examination, all imaging tests. Results A total 46 this study. made for 21...