A5103183878- Anesthesia and Neurotoxicity Research
- Ferroptosis and cancer prognosis
- Hydrogen's biological and therapeutic effects
- Phagocytosis and Immune Regulation
- Cellular transport and secretion
- Blood Coagulation and Thrombosis Mechanisms
- Cardiac Valve Diseases and Treatments
- Inflammasome and immune disorders
- Extracellular vesicles in disease
- Renin-Angiotensin System Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Connexins and lens biology
- Medical and Biological Ozone Research
- Bone and Joint Diseases
- Glutathione Transferases and Polymorphisms
- Aortic Disease and Treatment Approaches
- S100 Proteins and Annexins
- Autophagy in Disease and Therapy
- Cancer Cells and Metastasis
- Cancer, Lipids, and Metabolism
- Cardiac Ischemia and Reperfusion
- Genomics, phytochemicals, and oxidative stress
- Peroxisome Proliferator-Activated Receptors
- Bacterial biofilms and quorum sensing
- Inflammatory mediators and NSAID effects
Shanghai First People's Hospital
2018-2025
Shanghai Jiao Tong University
2017-2025
The First Affiliated Hospital, Sun Yat-sen University
2025
Zhongshan Hospital
2024-2025
Fudan University
2024-2025
Sun Yat-sen University
2025
Sir Run Run Shaw Hospital
2023
Zhejiang University
2023
Guizhou Provincial People's Hospital
2021-2022
Shanghai Chest Hospital
2017
Pyroptosis belongs to a novel inflammatory programmed cell death pathway, with the possible prognosis of endometrial cancer related terminal protein GSDMD. Hydrogen exerts biphasic effect on by promoting tumor and protecting normal cells, which might initiate GSDMD pathway-mediated pyroptosis.We performed immunohistochemical staining western immunoblotting analysis observe expression NLRP3, caspase-1, in human xenograft mice tissue lines. We investigated treatment hydrogen could boost ROS...
ABSTRACT EAL domain proteins are the major phosphodiesterases for maintaining cellular concentration of second-messenger cyclic di-GMP in bacteria. Given pivotal roles domains regulation many bacterial behaviors, elucidation their catalytic and regulatory mechanisms would contribute to effort deciphering signaling network. Here, we present data show that RocR, an protein regulates expression virulence genes biofilm formation Pseudomonas aeruginosa PAO-1, catalyzes hydrolysis by using a...
There is little data about the prognostic value of mitral annular dilatation (MAD) in patients with symptomatic severe aortic regurgitation (AR) undergoing transcatheter valve replacement (TAVR). This study aimed to assess prognosis computed tomography (CT)-determined MAD such patients. Consecutive AR who underwent pre-TAVR CT between May 2014 and 2023 were included this study. The clinical endpoint was composite outcome all-cause death heart-failure hospitalization. Mitral dimensions...
<title>Abstract</title> Background Endometrial cancer (EC) represents a common malignancy within gynecological cancers, characterized by notably high mortality rate. The absence of reliable prognostic biomarkers significantly impairs the effectiveness predictive, preventive, and personalized medicine (PPPM/3PM) strategies. Pyroptosis, distinct form programmed cell death, has been closely linked to anti-cancer immune responses. Nonetheless, precise role pyroptosis in context EC remains...
We demonstrated that drinking hydrogen-rich water (HRW) inhibits endometrial tumor growth in our previous work. This research is to identify differentially expressed proteins (DEPs) between HRW and purified groups a xenograft mouse model of cancer (EC).Samples were analyzed using tandem mass tags (TMTs) coupled with liquid chromatography-tandem spectrometry (LC-MS/MS). DEPs identified bioinformatics determine potential molecular functions immunohistochemical (IHC) staining.In total, 11 the...
In advanced and recurrent endometrial carcinoma (EC), the current state of immuno- or targeted therapy remains in clinical research phase. Our study aimed to explore role ESCRT machinery maintaining cell membrane integrity reversing pyroptotic death.Immunohistochemistry, western blotting, co-immunoprecipitation were performed determine expression relationship between GSDMD, CHMP4B, VPS4A. We employed techniques such as FITC Annexin V/propidium iodide staining, Ca2+ fluorescence intensity,...
Steroid-induced avascular necrosis of the femoral head (SANFH) is a mainly bilateral complication steroid therapy that involves extensive necrosis, and frequently occurs in young middle-aged individuals, with high disability rate. Autophagy an intracellular lysosomal degradation process occurring numerous diseases. However, effect dexamethasone (DXM)-induced autophagy on osteoblasts unclear. The aim present study was to investigate effects SANFH. In study, SANFH patients collected, samples...
The genes involved in the endosomal sorting required for transport complex (ESCRT)-III pathway is a protective mechanism that delays cell death by repairing damaged plasma membranes. We aimed to evaluate if targeting ESCRT-III may be used as biomarkers predicting clinical outcomes of endometrial carcinoma (EC).Transcriptome RNA sequence (RNA-seq) data and genomic information EC samples were obtained from Cancer Genome Atlas (TCGA). expression level, pathological relationship, alterations,...
Thyroid cancer-1 (TC-1), a natively disordered protein, is widely expressed in vertebrates and overexpressed many kinds of tumors. However, its exact role regulation mechanism human non-small cell lung cancer (NSCLC) are still unclear. In the present study, we found that TC-1 highly NSCLC aberrant expression strongly associated with proliferation. Exogenous overexpression promotes proliferation, accelerates G1-to-S-phase transition, reduces apoptosis NSCLC. The knockdown TC-1, however,...
To evaluate the activity of hydrogen in endometrial cancer and elucidate its underlying molecular mechanisms.Ishikawa, HEC1A AN3CA cells were incubated DMEM medium with or without hydrogen. RNA sequencing was used to explore association treatment signaling pathways functional genes cells. The apoptotic rates three evaluated by fluorescein isothiocyanate (FITC) Annexin V V-allophycocyanin (APC)/propidium iodide double staining.RNA analysis revealed that induced TNF/NF-κB apoptosis gene sets...
Background. Propofol acts as an intravenous anesthetic cure which is widely used a therapy for the craniocerebral injury that comprised surgical anesthesia well sedation done in intensive care units. one of most commonly and efficient anesthetics where painful effects are followed by injection propofol. In many cases, patients experience pain anxiety, boredom, fear, even myocardial ischemia. Objective. This study was performed to investigate underlying mechanism propofol its effect on...
Motivation and Problem Statement. Thiopental is an anesthetic drug related to the condition of controlling area neurological contexts. This study analysis effectiveness for thiopental application on spontaneously hypertensive rats. Methodology. We have evaluated induction as agent. The rats were selected administer in form anesthesia. selection strokes are derivation inducible model assess efficacy analyzing ischemic stroke parameters which relate human body. used middle cerebral artery...
Background. Osteosarcoma is one of the most prominent bone cancers which has a predominant occurrence in children and adolescents. This study focused on determining effects treatment gas anesthetics invasion, metastasis, chemosensitivity progression osteosarcoma cells. Material Methods. The biological common anesthetics—desflurane, isoflurane, sevoflurane—on cells were studied compared. assays performed for analysis cell migration proliferation. Results. Isoflurane sevoflurane have shown...
Abstract Background Atrial fibrillation (AF) is associated with left atrial (LA) mechanical dysfunction, which predisposes to stasis of blood within the LA and thus increases risk stroke. However, limited known about functional alterations appendage (LAA) in relation stages AF. Here, we sought analyse LAA mechanics during different AF detail. Methods A total 92 patients referring for radiofrequency ablation were consecutively enrolled. Patients categorized according rhythm AF:sustained...
Objective To investigate the effects of hypothermia combined with sevoflurane on expression myocardial gap junction protein connexin 43 (Cx43) in isolated rabbit hearts.Methods Healthy adult rabbits both sexes,weighing 1.5-2.0 kg,were sacrificed after anesthetization.The hearts were rapidly excised and perfused a langendorff apparatus K-H solution saturated 95％ O2-5％ CO2 at 37 ℃ apparatus.Forty randomly divided into 4 groups (n =10 each):control group (group C),hypothermia H) HS).At 15 min...
Summary: This study sought to investigate two possible mechanisms underlying the decrease in pressor response infused angiotensin II (Ang II) pregnancy. First, whether vascular Ang receptors show parallel regulatory changes their uterine counterparts during pregnancy and thus if a receptor number might explain this phenomenon. Second, we investigated possibility that rate of clearance from plasma was accelerated as basis for loss sensitivity. For studies age‐matched female Wistar‐Kyoto rats...