A5019807389- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Eosinophilic Disorders and Syndromes
- Acute Myeloid Leukemia Research
- Reproductive biology and impacts on aquatic species
- Ovarian function and disorders
- Acute Lymphoblastic Leukemia research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Adipose Tissue and Metabolism
- Lymphoma Diagnosis and Treatment
- Reproductive Biology and Fertility
- Retinoids in leukemia and cellular processes
- Ubiquitin and proteasome pathways
- Assisted Reproductive Technology and Twin Pregnancy
- Heart Rate Variability and Autonomic Control
- Cancer Risks and Factors
- Antioxidant Activity and Oxidative Stress
- Pregnancy and preeclampsia studies
- Lung Cancer Treatments and Mutations
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Non-Invasive Vital Sign Monitoring
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Gestational Diabetes Research and Management
- Histone Deacetylase Inhibitors Research
- Ovarian cancer diagnosis and treatment
Shanghai Jiao Tong University
2014-2025
Renji Hospital
2025
Shanghai First People's Hospital
2025
Ruijin Hospital
2013-2024
Shanghai Institute of Hematology
1999-2024
Second Affiliated Hospital of Nanjing Medical University
2024
China-Japan Friendship Hospital
2024
The University of Texas MD Anderson Cancer Center
2024
Xingtai University
2024
Xingtai Medical College
2024
Abstract Identifying novel drug targets to overcome resistance tyrosine kinase inhibitors (TKIs) and eradicating leukemia stem/progenitor cells are required for the treatment of chronic myelogenous (CML). Here, we show that ubiquitin-specific peptidase 47 (USP47) is a potential target TKI resistance. Functional analysis shows USP47 knockdown represses proliferation CML sensitive or resistant imatinib in vitro vivo. The knockout Usp47 significantly inhibits BCR-ABL T315I -induced mice with...
Germline stem cell lines possess the abilities of self-renewal and differentiation, have been established from both mouse human ovaries. Here, we a new female germline (FGSC) line post-natal rats by immunomagnetic sorting for Fragilis, which showed normal karyotype, high telomerase activity, consistent gene expression pattern primordial germ cells after 1 year culture. Using an in vitro differentiation system, FGSC could differentiate into oocytes. After liposome-based transfection with...
<title>Abstract</title> Background Endometrial cancer (EC) represents a common malignancy within gynecological cancers, characterized by notably high mortality rate. The absence of reliable prognostic biomarkers significantly impairs the effectiveness predictive, preventive, and personalized medicine (PPPM/3PM) strategies. Pyroptosis, distinct form programmed cell death, has been closely linked to anti-cancer immune responses. Nonetheless, precise role pyroptosis in context EC remains...
T-cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive that primarily caused by aberrant activation of the NOTCH1 signaling pathway. Recent studies have revealed posttranslational modifications, such as ubiquitination, regulate stability, activity, and localization. However, specific deubiquitinase affects protein stability remains unestablished. Here, we report ubiquitin-specific protease 7 (USP7) can stabilize NOTCH1. USP7 deubiquitinated in vivo vitro, whereas knockdown...
Imatinib, a tyrosine kinase inhibitor, exhibits competitive inhibition on the CYP450 2D6 isozyme with K(i) value of 7.5 microm. However, clinical significance and its relevance to polymorphisms have not been evaluated. The pharmacokinetics imatinib well studied in Caucasians, but Chinese population. Metoprolol, CYP2D6 substrate, has different clearances among patients genotypes. It is often used as probe substrate for drug-drug interaction studies.Co-administration at 400 mg twice daily...
Abstract Despite recent progress in the treatment, outcome of adult acute T-cell lymphoblastic leukemia (T-ALL) is poor. Development novel approach to combat this disease urgently required. Vorinostat, a pan-histone deacetylase (HDAC) inhibitor, exerts promising anticancer activity variety solid and hematologic malignancies. However, efficacy vorinostat monotherapy unsatisfactory. Here, we show that quinacrine (QC), an anti-malaria drug with potent autophagy inhibitory activity, could...
T-cell acute lymphoblastic leukemia (T-ALL) is a lymphoid malignancy caused by the oncogenic transformation of immature progenitors with poor outcomes. WP1130 has shown potent activity against variety cancer but whether anti-T-ALL not clear. USP24, one target WP1130, largest deubiquitinases and its detailed mechanism poorly understood. The aim this study was to explore could suppress T-ALL role USP24 in T-ALL.Molecular docking cellular thermal shift assay were performed determine how...
Chronic intermittent hypoxia (IH) contributes to obstructive sleep apnea (OSA)-related cardiovascular diseases through increasing oxidative stress. It has been widely recognized that estradiol decreases the risk for disease, but estrogen replacement therapy is limited its side effects. Thioredoxin (Trx) and endogenous inhibitor, thioredoxin-interacting protein (Txnip), are associated with protective effect of in some conditions. In this study, we aimed explore whether could protect against...
Background and purpose: Autonomic dysfunction is common after stroke, which correlated with unfavorable outcome. Phase-rectified signal averaging a newly developed technique for assessing cardiac autonomic function, by detecting sympathetic vagal nerve activity separately through calculating acceleration capacity (AC) deceleration (DC) of heart rate. In this study, we used the first time to investigate function patients acute hemispheric ischemic stroke. Methods: A 24-hour Holter monitoring...
In China, the frequency of mild hypertension cases remains prevalently high. Meanwhile, diets containing functional ingredients that control blood pressure have received considerable attention. this randomized, controlled intervention study, 65 participants were randomly assigned to consume 30 g whey protein or maltodextrin daily for 12 weeks. Blood pressure, body composition, biochemical analysis in plasma, and flow-mediated dilation (FMD), an index evaluating endothelial function,...
Objective The primary objective of the study was to assess traditional Chinese formula DKP supplementation in terms efficacy and safety on reproductive outcomes expected poor ovarian responder (POR, POSEIDON Group 4) undergoing vitro fertilization-embryo transfer (IVF-ET). Design, Setting, Participants Women eligible for IVF-ET were invited participate this randomized, double-blind, placebo-controlled, superiority trial at academic fertility centers ten public hospitals Mainland. A total 462...