A5100740269- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Neuroendocrine Tumor Research Advances
- Gallbladder and Bile Duct Disorders
- Gastrointestinal disorders and treatments
- Liver Disease Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Neurological Disease Mechanisms and Treatments
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- COVID-19 Clinical Research Studies
- Dermatological and COVID-19 studies
- Acute Ischemic Stroke Management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal Tumor Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Chronic Lymphocytic Leukemia Research
- Cerebrovascular and Carotid Artery Diseases
- Regulation of Appetite and Obesity
- Lung Cancer Research Studies
Capital Medical University
2016-2025
Nanchang University
2017-2025
First Affiliated Hospital of Nanchang University
2017-2025
Southern Medical University
2012-2025
Huazhong University of Science and Technology
2023-2025
First Affiliated Hospital of Soochow University
2025
Soochow University
2025
Nanjing Medical University
2007-2025
Peking University Third Hospital
2017-2025
Second Hospital of Anhui Medical University
2018-2025
Abstract Background Metabolic reprogramming and epigenetic alterations contribute to the aggressiveness of pancreatic ductal adenocarcinoma (PDAC). Lactate-dependent histone modification is a new type mark, which links glycolysis metabolite process lactylation. However, role lactylation in PDAC remains unclear. Methods The level was identified by western blot immunohistochemistry, its relationship with overall survival evaluated using Kaplan-Meier plot. participation growth progression...
China's methadone maintenance treatment program was initiated in 2004 as a small pilot project just eight sites. It has since expanded into nationwide encompassing more than 680 clinics covering 27 provinces and serving some 242 000 heroin users by the end of 2009. The agencies that were tasked with program's expansion have been confronted many challenges, including high drop-out rates, poor cooperation between local governing authorities service quality at counter. In spite these...
Objectives The aim of this study was to determine the etiology tendency acute pancreatitis (AP) in Beijing region and relationship with influencing factors. Methods This retrospective multicenter enrolled 8 representative general hospitals from January 1, 2006 December 31, 2010. analyzed, defined sex, aging, severity, mortality, recrudesce rate, length stay, hospitalization cost. Results 2461 patients. total number increasing year by year. Causes included biliary (1372, 55.75%), alcoholism...
Abstract Deciphering universal gene regulatory mechanisms in diverse organisms holds great potential for advancing our knowledge of fundamental life processes and facilitating clinical applications. However, the traditional research paradigm primarily focuses on individual model does not integrate various cell types across species. Recent breakthroughs single-cell sequencing deep learning techniques present an unprecedented opportunity to address this challenge. In study, we built extensive...
Abstract Plant-derived alkaloids are an important class of pharmaceuticals. However, they still rely on phytoextraction to meet their diverse market demands. Since multistep biocatalytic cascades have begun revolutionize the manufacture natural or unnatural products, address synthetic challenges alkaloids, herein we establish artificially concise four-enzyme cascade with avoiding plant-derived P450 modification for synthesizing phenethylisoquinoline (PEIAs) after enzyme discovery and...
Primary closure following laparoscopic common bile duct exploration (LCBDE) has been widely adopted because of the efficacy and safety in treatment (CBD) stones. However, risk factors for leakage, most complication after primary closure, not clarified yet.A retrospective cohort study patients who underwent LCBDE with choledochotomy between Feb. 2012 Jun. 2016 was performed. Risk leakage were identified by logistic regression inculding demographic factors, preoperative condition surgical...
Although laparoscopic surgery has been recommended as an optional therapy for patients with early gastric cancer, whether locally advanced cancer (AGC) could benefit from laparoscopy-assisted distal gastrectomy (LADG) D2 lymphadenectomy remains elusive due to a lack of comprehensive clinical data. To evaluate the efficacy LADG, we conducted multi-institutional randomized controlled trial compare versus open (ODG) AGC in North China. In this RCT, after were enrolled according eligibility...
PURPOSE Complete mesocolic excision (CME) is being increasingly used for the treatment of right-sided colon cancer, although there still no strong evidence that CME provides better long-term oncological outcomes than D2 dissection. The controversy mainly regarding survival benefit from extended lymph node dissection emphasized by CME. METHODS This multicenter, open-label, randomized controlled trial (ClinicalTrials.gov identifier: NCT02619942 ) was performed across 17 hospitals in China....
Abstract Background Liver Hepatocellular carcinoma (LIHC) exhibits a high incidence of liver cancer with escalating mortality rates over time. Despite this, the underlying pathogenic mechanism LIHC remains poorly understood. Materials & methods To address this gap, we conducted comprehensive investigation into role G6PD in using combination bioinformatics analysis database data and rigorous cell experiments. samples were obtained from TCGA, ICGC GEO databases, differences expression...
The mechanism of pancreatic damages induced by chronic high-fat diets (HFDs) remains unknown. current study was to detect the involvement free fatty acids (FFAs) and lipid peroxidation in injuries rats a long-term HFD.Rats HFD groups (n = 12) were fed with an for 2, 4, 6, 10, 18 weeks, respectively. Pancreatic malondialdehyde content concentration FFA measured. Histopathologic changes observed Sirius red staining fibrosis immunostaining stellate cells desmin, alpha-smooth muscle actin,...
Background: Hypertriglyceridemia (HTG) is the most common etiology of acute pancreatitis (AP) after alcohol and gallstone-induced disease. Elevation serum triglyceride (TG) levels to ≥1000 mg/dl in a patient with AP strongly indicates HTG as cause. The absolute risk based on TG ≤1000 has not been clearly defined. aims this study were address role elevated between 500 1000 clinical course (HTGP); assess relationship level disease severity. Methods: A total 224 HTGP patients 2007 2011 divided...
Acute pancreatitis (AP) is a common acute abdominal disease worldwide, and its incidence rate has increased annually. Approximately 20% of AP patients develop into necrotizing (NP), 40% to 70% NP have infectious complications, which usually indicate worse prognosis. Infection an important sign complications in patients.To investigate the difference infection time, site, strain with complications.The clinical data visiting Department General Surgery Xuanwu Hospital Capital Medical University...
Theaflavin has been proven to own strong antioxidative capacity; however, the molecular mechanism underlying its protective effect against cerebral ischemia‑reperfusion (I/R) injury remains unclear. Therefore, present study was designed elucidate neuroprotective effects of theaflavin on I/R and mechanisms. To investigate neurological function, neurogenesis, oxidative stress, experiments were performed using a rat model, neural stem cells (NSCs) subjected oxygen‑glucose deprivation...