A5052753033- Bariatric Surgery and Outcomes
- Gastric Cancer Management and Outcomes
- Gallbladder and Bile Duct Disorders
- Esophageal and GI Pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Body Contouring and Surgery
- Cardiovascular Disease and Adiposity
- Hernia repair and management
- Metastasis and carcinoma case studies
- Thyroid and Parathyroid Surgery
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer Cells and Metastasis
- Gastrointestinal Tumor Research and Treatment
- Appendicitis Diagnosis and Management
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Gastroesophageal reflux and treatments
- Cancer-related molecular mechanisms research
- Software Engineering Research
- Voice and Speech Disorders
Beijing Shijitan Hospital
2016-2025
Peking University
2016-2025
Capital Medical University
2016-2025
Jiangnan University
2024
Shandong University
2022
Shandong University of Science and Technology
2021
Shanghai Tongji Urban Planning and Design Institute
2021
American Diabetes Association
2018
Creative Commons
2018
Jiangxi Normal University
2015-2016
In the clinical practice of neoadjuvant chemotherapy, response markers are very important. We aimed o investigate whether tumor CEA(carcino-embryonic antigen), CA19-9(carbohydrate antigen 19-9), CA72-4(carbohydrate 72-4), and CA125(carbohydrate 125) can be used to evaluate diagnosis prognosis value four in patients gastric cancer.A retrospective review was performed 184 cancer who underwent a 5-Fu, leucovorin, oxaliplatin (FOLFOX) chemotherapy regimen, followed by surgical treatment. Blood...
Although laparoscopic surgery has been recommended as an optional therapy for patients with early gastric cancer, whether locally advanced cancer (AGC) could benefit from laparoscopy-assisted distal gastrectomy (LADG) D2 lymphadenectomy remains elusive due to a lack of comprehensive clinical data. To evaluate the efficacy LADG, we conducted multi-institutional randomized controlled trial compare versus open (ODG) AGC in North China. In this RCT, after were enrolled according eligibility...
To compare the remission of type 2 diabetes mellitus (T2DM) through treatment with laparoscopic sleeve gastrectomy (LSG) or Roux-en-Y gastric bypass (LRYGB), and to analyze cost-effectiveness medical treatment, LSG, LRYGB in T2DM patients (BMI ≥ 28). A 2-group randomized controlled trial was conducted at Diabetes Surgery Centre, Beijing Shijitan Hospital Beijing, China. Subjects were 80 ages 16 65 years a body mass index 28 kg/m2 more duration no than 15 years. randomly assigned (1:1)...
Background: The only human cathelicidin, LL-37, and the innate defense regulator peptide IDR-1, which have been proven to antimicrobial activity, represent essential elements of immunity. Our previous study showed that LL-37 was protective in vitro attenuate LTA-induced inflammatory effects. Methicillin-resistant staphylococcus aureus (MRSA) causes a multitude serious sometimes life-threatening diseases around globe. However, effect IDR-1 MRSA-induced pneumonia is unknown. In present study,...
To the Editor: Obesity and type 2 diabetes (T2D) present significant health issues in China. Despite generally having lower body mass index (BMI) thresholds than Western populations, Chinese individuals often experience higher rates of central obesity, leading to increased metabolic risks even at BMI levels. The prevalence T2D among adults China is estimated be 11.2%. Traditional treatments, including lifestyle interventions medications, fail achieve sustained weight loss effective glycemic...
Introduction: As the most common postoperative complication, intestinal adhesions can cause obstruction, female infertility, and even endanger life. The currently developed materials for preventing mainly focus on physical barriers reducing inflammatory reactions, while neglecting importance of effectively promoting rapid repair peritoneum. We previously found that platelet-rich fibrin (PRF) prevent adhesions. proliferation mesothelial cells may play a significant role in adhesions, but...
Current therapies to treat advanced hepatocellular carcinoma (HCC) are not satisfactory because of the high rate recurrence after treatment and severe complications surgery. Cancer vaccines have been studied for decades achieve effective, micro-invasive, long-lasting anti-tumor action. designed promote tumor-specific immune responses increase specific cytotoxic CD8-positive T cells. This review summarizes 16 phase I clinical trials cancer against HCC that conducted over past 10 years....
Abstract Background and Aim To identify individuals with metabolic dysfunction‐associated steatohepatitis (MASH) or “at‐risk” MASH among patients steatotic liver disease (MASLD), three noninvasive models are available satisfactory efficiency, which include magnetic resonance imaging [MRI]‐ AST (MAST), FibroScan‐AST (FAST score), elastography [MRE] plus FIB‐4 (MEFIB). We aimed to evaluate the most accurate approach for diagnosing MASH. Methods included 108 biopsy‐proven MASLD who underwent...
This research aimed to investigate the differential expression of apurinic-apyrimidinic endonuclease 1 (APE1) in hepatocellular carcinoma (HCC) tissues and cells effects on proliferation apoptosis cancer cells. Immunohistochemical techniques were used detect APE1 80 cases HCC corresponding paracancerous tissue microarrays; meanwhile, Western blots both human BEL-7402, BEL-7405, HCC-9204, Hep3B, HepG2, SMMC-7721 Huh-7 cells, normal hepatocyte L-02 The relationship between clinical...
Aim. To investigate the characteristic of hypertriglyceridemic- (HTG-) induced pancreatitis (HTG pancreatitis). Methods. We reviewed 126 cases HTG and 168 biliary as control. Results. The group mean age was younger than group. number females a little higher males in both groups. There were 18 that recurrent 11 billiary hospitalization times 13.7 ± 2.6 11.2 2.3 days two Six patients received apheresis proportion severe AP 31.0% 26.2%, mortality 1.6% 1.2%, comorbidity diabetes mellitus (DM)...
Tumor resistance to radiotherapy is one of the main obstacles clinical treatment nasopharyngeal carcinoma (NPC). Improving radiosensitivity tumor cells has an important significance in NPC. This study aimed identify that miR-138-1-3p as a novel therapeutic target radioresistant NPC and found its targets, CRIPTO JAK2/STAT3 pathway.Radioresistant C666-IR HK-1R were derived from cell lines C666-1 HK-1. The different microRNAs (miRNAs) their targeting genes analyzed between using microarray...
Background. Construction of the transcriptional regulatory network can provide additional clues on mechanisms and therapeutic applications in gastric cancer. Methods. Gene expression profiles cancer were downloaded from GEO database for integrated analysis. All DEGs analyzed by GO enrichment KEGG pathway enrichment. Transcription factors further identified then a global was constructed. Results. By analysis six eligible datasets (340 cases 43 controls), bunch 2327 identified, including 2100...
Our purpose was to explore the remission of insulin resistance after bariatric surgery discover mechanism diabetes excluding dietary factors. A retrospective case control study conducted on patients with type 2 diabetes, who underwent laparoscopic sleeve gastrectomy (LSG) or gastric bypass (LGB) in Beijing Shijitan Hospital from April 1, 2012 2013. The laboratory and anthropometric data analyzed pre-surgery during a 2-year follow-up. HOMA-IR calculated evaluated. two surgical procedures were...
To date, long-term safety including functional outcomes of transanal natural orifice specimen extraction surgery (NOSES) for colorectal cancer resection has not been confirmed.To explore the short- and as well anal function NOSES versus conventional laparoscopic sigmoid colon or rectal resection.A retrospective review data from a prospectively maintained database was performed to analyze 69 patients who underwent resections another matched (CL) surgery. Anal evaluated using Wexner fecal...
Abstract It is undetermined when and how laparoscopic common bile duct exploration (LCBDE) should be used in patients with (CBD) stone-related nonsevere acute cholangitis. We aimed to evaluate the effect of LCBDE on clinical outcome those within (early) or beyond (delayed) 72 hours emergent admission. Surgery-related complications, length hospital stay (LOS) total cost, as well demographic parameters were compared between two groups. Finally, 3 5 early delayed group, respectively, had...
Abstract Background In the past quite a long time, intraoperative cholangiography(IOC)was necessary during laparoscopic cholecystectomy (LC). Now magnetic resonance cholangiopancreatography (MRCP) is main method for diagnosing common bile duct stones (CBDS). Whether MRCP can replace IOC as routine examination before LC still inconclusive. The aim of this study was to analyze clinical data patients undergoing cholecystolithiasis, and explore necessity feasibility preoperative in with...
Chemoresistance is one of the main reasons for poor prognosis pancreatic cancer. The effects mesothelin (MSLN) on chemoresistance in cancer are still unclear. We aim to investigate potential roles MSLN and its relationship with proliferation, epithelial-mesenchymal transition (EMT) stemness cells. Human cell lines ASPC-1 Mia PaCa-2 high low expression MSLN, respectively, were selected. knockout (KO) overexpression (OE) generated. phenotypes, EMT-related markers, clone formation, tumor sphere...
Laparoscopic distal gastrectomy (LDG) has become a common procedure for treating advanced gastric cancer (AGC) in China. However, there is uncertainty regarding its oncological outcomes compared to open (ODG). This study aims compare the 3-year disease-free survival (DFS) rates among patients who underwent surgery AGC northern
Background: The global prevalence of non-alcoholic fatty liver disease (NAFLD) is approximately 30%, and the condition can progress to steatohepatitis, cirrhosis, hepatocellular carcinoma. Metabolic bariatric surgery (MBS) has been shown be effective in treating obesity related disorders, including NAFLD. Objective: In this study, comprehensive machine learning was used identify biomarkers for precise treatment NAFLD from perspective MBS. Methods: Differential expression univariate logistic...