A5100688678- Redox biology and oxidative stress
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- Chemical Synthesis and Analysis
- Hydrogels: synthesis, properties, applications
- Sulfur Compounds in Biology
- Ubiquitin and proteasome pathways
- RNA Interference and Gene Delivery
- Genomics, phytochemicals, and oxidative stress
- Enzyme function and inhibition
- Circular RNAs in diseases
- Carbohydrate Chemistry and Synthesis
- Glutathione Transferases and Polymorphisms
- Cancer therapeutics and mechanisms
- RNA and protein synthesis mechanisms
- Selenium in Biological Systems
- Glycosylation and Glycoproteins Research
- Signaling Pathways in Disease
- Protein Degradation and Inhibitors
- Histone Deacetylase Inhibitors Research
- Analytical Chemistry and Chromatography
- Cancer Research and Treatments
- Synthesis and Biological Evaluation
Beijing Shijitan Hospital
2025
Capital Medical University
2025
Shandong Mental Health Center
2022-2024
Shandong University
2022-2024
Shenyang Medical College
2018-2024
Tianjin Stomatological Hospital
2022-2023
Ningbo University
2022-2023
Nanchang University
2021-2023
Third Affiliated Hospital of Nanchang University
2021-2023
Nanjing University of Science and Technology
2023
Phosphoinositide 3 kinase/Akt pathway plays an essential role in neuronal survival. However, the cellular mechanisms by which Akt suppresses cell death and protects neurons from apoptosis remain unclear. We previously showed that transient expression of constitutively active inhibits ceramide-induced hybrid motor neuron 1 cells. Here we show stable either or Bcl-2 apoptosis, but only prevents release cytochrome c mitochondria, suggesting regulates at a postmitochondrial level. Consistent...
Abstract Small molecule probes are indispensable tools to explore diverse cellular events. However, finding a specific probe of target remains high challenge. Here we report the discovery Fast-TRFS, and superfast fluorogenic mammalian thioredoxin reductase, ubiquitous enzyme involved in regulation redox signaling pathways. By systematically examining processes fluorophore release reduction cyclic disulfides/diselenides by enzyme, structural factors that determine response rate specificity...
As an underwater thruster, the pump-jet propulsor (PJP) exhibits low radiation noise but generates significant line spectral in low-frequency band. In this paper, we equipped PJP hub with two types of propeller boss cap fins (PBCF): one fixed and other rotating rotor. The hybrid large eddy simulation Reynolds-averaged Navier–Stokes method, along Ffowcs Williams-Hawkings (FW-H) equation, are employed to systematically analyze hydrodynamics, exciting force, flow noise, field PJPs. results...
Elevated reactive oxygen species and antioxidant defense systems have been recognized as one of the hallmarks cancer cells. As a major regulator cellular redox homeostasis, selenoprotein thioredoxin reductase (TrxR) is increasingly considered promising target for anticancer drug development. The current approach to inhibit TrxR predominantly relies on modification selenocysteine residue in C-terminal active site enzyme, which it hard avoid off-target effects. By conjugating gemcitabine with...
The first-generation chemical probes for species-selective fluorescence imaging of human senescence-associated β-galactosidase are developed.
The 1,2-diselenolane unit is a general scaffold to construct glutathione-dependent prodrugs that show increased potency cancer cells, and work<italic>via</italic>a combination of chemotherapy oxidative stress.
Introduction: As the most common postoperative complication, intestinal adhesions can cause obstruction, female infertility, and even endanger life. The currently developed materials for preventing mainly focus on physical barriers reducing inflammatory reactions, while neglecting importance of effectively promoting rapid repair peritoneum. We previously found that platelet-rich fibrin (PRF) prevent adhesions. proliferation mesothelial cells may play a significant role in adhesions, but...
Despite the recent advancements driven by deep learning, de novo peptide sequencing is still constrained incomplete fragmentation and insufficient protein digestion in current single protease-based proteomic experiments. Here, we present a software system, named DiNovo, for high-coverage confidence leveraging complementarity of mirror proteases. DiNovo empowered several innovative algorithms, including mirror-spectra recognition algorithm independent pre-sequencing, two algorithms based on...
Abstract A novel superabsorbent polymer composite was synthesized by graft copolymerization of cottonseed protein and acrylic monomers in order to explore the new application nonfood field. This solution based copolymerization, using partly neutralized acid, acrylamide as raw material, N , ‐methylene bisacrylamide crosslinking agent, potassium persulphate sodium sulfite initiators. The effects certain variables on water absorbency were measured. chemical structure characterized means Fourier...
The synthetic challenges in glycobiology and glycochemistry hamper the development of glycobiomaterials for biomedicine. Here we report use molecular self-assembly to sidestep laborious synthesis complex glycans promoting proliferation murine embryonic stem (mES) cells. Our study shows that supramolecular assemblies a small molecule conjugate nucleobase, amino acids, saccharide, as de novo glycoconjugate, promote mES cells zygotes into blastocysts mouse. Molecular engineering confirms each...
The first thiol-specific turn-on probe, BODIPY-TS, utilizing a thiosulfonate scaffold as the thiol recognition unit was reported. BODIPY-TS displays low toxicity, and features high sensitivity, fast response quantitative reaction towards thiols. structural novelty of would guide development novel probes.
Xanthatin (XT), a naturally occurring sesquiterpene lactone presented in cocklebur (Xanthium strumarium L.), is under development as potential anticancer agent. Despite the promising effect of XT, molecular mechanism underlying its cellular action has not been well elucidated. The mammalian thioredoxin reductase (TrxR) enzymes, essential seleno-flavoproteins containing penultimate selenocysteine (Sec) residue at C-terminus, represent target for cancer chemotherapeutic agents. In this study,...
The mechanisms underlying neurodegenerative diseases are not fully understood yet. However, an increasing amount of evidence has suggested that these disorders related to oxidative stress. We reported herein lipoamide (LM), a neutral amide derivative lipoic acid (LA), could resist stress-mediated neuronal cell damage. LM is more potent than LA in alleviating hydrogen peroxide- or 6-hydroxydopamine-induced PC12 injury. Our results reveal promotes the nuclear accumulation NFE2-related factor 2...