A5100389478- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Natural Compound Pharmacology Studies
- Pharmacological Effects of Natural Compounds
- Toxin Mechanisms and Immunotoxins
- Phytochemistry and Bioactive Compounds
- Ginseng Biological Effects and Applications
- Essential Oils and Antimicrobial Activity
- Plant Toxicity and Pharmacological Properties
- Sesquiterpenes and Asteraceae Studies
- Natural Compounds in Disease Treatment
- Biological Activity of Diterpenoids and Biflavonoids
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Neurological Disease Mechanisms and Treatments
- Phytochemical compounds biological activities
- Biological and pharmacological studies of plants
- Plant-based Medicinal Research
- Skin Protection and Aging
- Synthesis of Organic Compounds
- Bioactive Compounds and Antitumor Agents
- Bioactive natural compounds
- Plant-derived Lignans Synthesis and Bioactivity
- Antibiotics Pharmacokinetics and Efficacy
- Phytochemistry and biological activity of medicinal plants
China Pharmaceutical University
2016-2025
Tianjin Medical University
2011-2024
Tianjin Hospital
2024
Harbin Institute of Technology
2024
Beijing University of Chemical Technology
2024
Hubei University of Chinese Medicine
2024
Charles Darwin University
2022-2023
Sichuan University
2020-2023
West China Hospital of Sichuan University
2023
Southeast University
2022
Iron oxide nanoparticles (IONPs) are chemically inert materials and have been mainly used for imaging applications drug deliveries. However, the possibility whether they can be as therapeutic drugs themselves has not yet explored. We reported here that Fe2O3 (NPs) protect hearts from ischemic damage at animal, tissue cell level. The cardioprotective activity of NPs requires integrity is dependent upon their surface charges molecules were integrated into nanoparticles. Also, showed no...
Chemotherapy-induced myelosuppression (CIM) significantly impairs hematopoiesis. Trilaciclib (TC), originally developed for oncology application, is the only FDA-approved CDK4/6 inhibitor CIM, which effectively protects bone marrow cells by inhibiting their proliferation. In this study, a series of TC derivatives were designed and synthesized as inhibitors (CDK4/6i) alleviating CIM. Among these, 42 displayed potent inhibitory activity (IC50 = 11 nM), lower cytotoxicity (CC50 > 100 μM) showed...
Fibrinolysis, the natural process of blood clot dissolution regulated by plasmin, plays a crucial role in preserving vascular health. Nevertheless, if this becomes hyperactive, it can lead to severe bleeding episodes, particularly instances traumatic injuries. Conventional antifibrinolytics such as ε-aminocaproic acid (EACA) and tranexamic (TXA) exhibit limited impact attributed their modest potency. The substantial dosage volume necessary for effectiveness, along with safety concerns,...
Frutescones H-R (1-11), new sesqui- or monoterpene-based meroterpenoids, were isolated from the aerial parts of Baeckea frutescens. Their structures and absolute configurations established by means spectroscopic analyses (HRESIMS, 1D 2D NMR, ECD), as well single-crystal X-ray crystallography 1, (-)-7, 9. The anti-inflammatory activities all isolates evaluated measuring their inhibitory effects on NO production in LPS-stimulated RAW 264.7 macrophages, structure-activity relationships 1-11 are...
Frutescone A-G [(1-6), (+)-7, (-)-7], a new group of naturally occurring tasmanone-based meroterpenoids, were isolated from the aerial parts Baeckea frutescens L. Compounds 1 and 4 featured rare carbon skeleton with an unprecedented oxa-spiro[5.8] tetradecadiene ring system, existing as two favored equilibrating conformers in CDCl3 solution, identified by variable-temperature NMR. The regioselective syntheses 4-7 achieved concise manner biomimetically inspired key hetero-Diels-Alder reaction...
Poly (ADP-ribose) polymerase-1 (PARP-1) is a potential target for the discovery of chemosensitizers and anticancer drugs. Amentoflavone (
The first thiol-specific turn-on probe, BODIPY-TS, utilizing a thiosulfonate scaffold as the thiol recognition unit was reported. BODIPY-TS displays low toxicity, and features high sensitivity, fast response quantitative reaction towards thiols. structural novelty of would guide development novel probes.
Glycogen synthase kinase-3β (GSK-3β) is a key enzyme in hyperphosphorylation of tau proteins and promising therapeutic target Alzheimer's disease (AD). Here, we reported, for the first time, that stereoisomers Schisandrin B (Sch B), (+)-1, (−)-1, (+)-2, (−)-2, were potent GSK-3β inhibitors. They demonstrated to selectively an orthosteric binding mode, with IC50 values 340, 290, 80, 70 nM, respectively. Further study showed these can significantly increase expression p-GSK-3β (Ser9) decrease...
Abstract Background and Purpose Kaempferol‐3‐ O ‐sophoroside ( PCS‐1 ) is the main component in Crocus sativus (Saffron), a herb with mood‐enhancing properties. AMP‐activated protein kinase (AMPK) potential therapeutic target for depression. This study explores antidepressive‐like properties of its AMPK activation to confirm as antidepression. Experimental Approach Corticosterone (CORT)‐induced PC12 cell injury served an vitro model evaluate neuroprotective effect . Neuro‐2a cells primary...
Four novel taxane derivatives, N-debenzoyl-N-methyl-N-heptanoyl-taxol (1), N-debenzoyl-N-me-thyl-N-octanoyl-taxol (2), N-debenzoyl-N-methyl-N-(4-methylhexanoyl)-taxol (3), and N-debenzoyl-N-methyl-N-[(4Z)-1-oxo-4-tenenoyl]-taxol (4), were isolated from the ethanol extract of whole plant Taxus wallichiana.var.mairer. These structures identified on basis extensive spectroscopic analysis, their antitumor activity was evaluated against MCF-7, A549, 3-AO cancer cell lines by MTT method. Compound...
One new guaiane-type sesquiterpene glycoside, 2′-O-E-caffeoyl-8α-hydroxy-11α,13-dihydro-3β-O-β-D-glucozaluzanin C (1), was isolated from the whole herb of Ainsliaea fragrans (Compositae), together with five known lactones: 8α-hydroxy-11α,13-dihydro-3β-O-β-D-glucozaluzanin (2), 8α-hydroxy-11α,13-dihydrozaluzanin (3), 3α-hydroxy-11β,13-dihydro-8α-O-β-D-glucozaluzanin (4), 3β-hydroxy-11β,13-dihydro-8α-O-β-D-glucozaluzanin (5), 3β-O-β-D-glucozaluzanin (6). The structures compounds were...