A5100358946- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Virus-based gene therapy research
- Hepatitis B Virus Studies
- Sesquiterpenes and Asteraceae Studies
- Cancer Research and Treatments
- Alkaloids: synthesis and pharmacology
- Hepatitis C virus research
- Ginger and Zingiberaceae research
- Essential Oils and Antimicrobial Activity
- Berberine and alkaloids research
- Plant Toxicity and Pharmacological Properties
- Traditional and Medicinal Uses of Annonaceae
- HIV/AIDS drug development and treatment
- Plant-based Medicinal Research
- Phytochemical compounds biological activities
- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- RNA Interference and Gene Delivery
- Ginseng Biological Effects and Applications
- Bioactive Natural Diterpenoids Research
- Phytochemical Studies and Bioactivities
- Genetic diversity and population structure
- Piperaceae Chemical and Biological Studies
- Plant biochemistry and biosynthesis
Xinjiang Academy of Animal Science
2013-2025
Southwest University of Science and Technology
2024
Sichuan Agricultural University
2023-2024
Kunming Institute of Botany
2014-2023
Chinese Academy of Sciences
2014-2023
University of Chinese Academy of Sciences
2009-2023
Yunnan Agricultural University
2022-2023
Shandong University
2023
State Key Laboratory of Microbial Technology
2023
West China Second University Hospital of Sichuan University
2023
9α,13α-Dihydroxylisopropylidenylisatisine A (1), which was derived from isatisine (2) and possessed an unprecedented fused pentacyclic skeleton, isolated the leaves of Isatis indigotica Fort. The structure relative configuration were elucidated on basis extensive NMR analyses finally determined by single-crystal X-ray diffraction. Compound 1 showed moderate anti-HIV-1 activity with EC50 = 37.8 μM SI 7.98.
Abstract Spermatogenesis is a fundamental process in male reproductive biology and depends on precise balance between self-renewal differentiation of germ cells. However, the regulative factors for controlling are poorly understood. In this study, we examined roles amh dmrt1 cell development by generating their mutants with Crispr/Cas9 technology zebrafish. Amh mutant zebrafish displayed female-biased sex ratio, both female developed hypertrophic gonads due to uncontrolled proliferation...
Abstract The presence of neuritic plaques is a pathological hallmark Alzheimer’s disease (AD). However, the origin extracellular β‐amyloid peptide (Aβ) deposits and process plaque development remain poorly understood. present study attempted to explore pathogenesis by localizing β‐secretase‐1 (BACE1) elevation relative Aβ accumulation synaptic/neuritic alterations in forebrain, using transgenic mice harboring familial AD (FAD) mutations (5XFAD 2XFAD) as models. In animals with fully...
Leading by cytotoxicity against HepG2 cells, bioactivity-guided fractionation of the EtOAc fraction from Artemisia atrovirens led to isolation 18 new guaianolide dimers, artematrolides A–R and lavandiolides A, B, C, H, J. Eight compounds (1, 4, 10, 12, 13, 19–21) were unambiguously confirmed single-crystal X-ray diffraction analyses, others elucidated based on IR, UV, HRESIMS, 1D 2D NMR experiments, comparison experimental calculated ECD data. Structurally, all them [4 + 2] Diels–Alder...
Comprehensive Summary 17 new guaiane‐type sesquiterpenoid dimers (GSDs), artemzhongdianolides B1—B17 ( 1 — ), were isolated from Artemisia zhongdianensis under the guidance of bioassay, and elucidated by spectral analyses (HRESIMS, 1D 2D NMR, IR, ECD). The absolute configuration compounds , 3 7 9 10 13 was determined single‐crystal X‐ray diffraction analyses. Structurally, B1 ) B2 2 first example GSDs fused via a C‐13/C‐13' single bond, B3—B17 [4 + 2] Diels–Alder adducts two monomeric...
A novel population of cells that express typical immature neuronal markers including doublecortin (DCX+) has been recently identified throughout the adult cerebral cortex relatively large mammals (guinea pig, rabbit, cat, monkey and human). These are more common in associative relative to primary cortical areas appear develop into interneurons type II nitrinergic neurons. Here we further describe these amygdala, comparison with DCX+ hippocampal dentate gyrus, three age groups rhesus monkeys:...
One unusual resveratrol tetramer, paeonilactiflorol (1), and 14 known compounds (2–15) were isolated from peony seeds (Paeonia lactiflora) under the guidance of bioassay. Paeonilactiflorol (1) was determined by extensive HRESIMS, UV, IR, 1D 2D NMR spectroscopic analyses. Most stilbenes showed obvious inhibition on PTP1B α-glucosidase, superior to monoterpene glycosides. Especially, stilbene tetramer trimer (8) exhibited high activity inhibiting both with IC50 values 27.23 27.81 μM...
CRISPR/Cas9 technology has been widely utilized to enhance productive performance, increase disease resistance and generate medical models in livestock. The FecB allele sheep is a mutation the BMPRIB gene, recognized as first major gene responsible for high fecundity trait sheep, leading an increased ovulation rate ewe. In this study, we employed CRISPR/Cas9-mediated homologous-directed repair (HDR) introduce defined point (c.746 A > G) using single-stranded oligonucleotides (ssODN) ligase...
As one of the most important carbon sinks and pools globally, forest ecosystems play a critical role in absorbing storing dioxide from atmosphere. The implementation eco-engineering has transformed China into hotspots global greening. However, great differences natural conditions between subregions, function transformation ecosystem gain loss due to rapid land use changes, uncertainties stability sustainability functions resulting climate change, lead large-scale sink capacity future...
Background: Chronic kidney disease (CKD) is a global health concern, with renal fibrosis being major pathological feature. Empagliflozin (Empa), Sodium-glucose co-transporter-2 (SGLT2) inhibitor, has shown promise in protecting the kidney. This study aimed to investigate effects of Empa on non-diabetic CKD model and elucidate underlying mechanisms. Methods: We established using 5/6 nephrectomy (5/6 Nx) rats divided them into three groups: placebo-treated sham surgery rats, Nx Empa-treated...