A5100391507- T-cell and Retrovirus Studies
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Pituitary Gland Disorders and Treatments
- Plant Stress Responses and Tolerance
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- Plant Molecular Biology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Mechanisms and Therapy
- Neuroblastoma Research and Treatments
- Glioma Diagnosis and Treatment
- Liver physiology and pathology
- Esophageal Cancer Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Plant Gene Expression Analysis
- Pancreatic and Hepatic Oncology Research
First People's Hospital of Yunnan Province
2024-2025
Nanjing Medical University
2017-2025
Jiangsu Province Hospital
2025
Zhengzhou University
2024-2025
Institute of Laboratory Animal Science
2015-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Weatherford College
2024
Eastern Hepatobiliary Surgery Hospital
2010-2024
Second Military Medical University
2010-2024
Southeast University
2023-2024
Diabetic nephropathy is a growing health concern with characteristic sterile inflammation. As the underlying mechanisms of this inflammation remain poorly defined, specific therapies targeting in diabetic are lacking. Intriguingly, an association inflammasome activation has recently been shown, but pathophysiological relevance finding remains unknown. Within glomeruli, was detected endothelial cells and podocytes humans mice glucose-stressed glomerular vitro. Abolishing Nlrp3 or caspase-1...
Increasing evidence suggests that the presence of endotoxemia is substantial clinical relevance to patients with cirrhosis, but it unclear whether and how gut-derived LPS amplifies tumorigenic response liver. We found circulating levels were elevated in animal models carcinogen-induced hepatocarcinogenesis. Reduction using antibiotics regimen rats or genetic ablation its receptor Toll-like 4 (TLR4) mice prevented excessive tumor growth multiplicity. Additional investigation revealed TLR4...
One of the two branches α-linolenic acid metabolism pathway is catalyzed by 12-oxo-phytodienoic reductase I, and other involved in jasmonic (JA) synthesis. The former known to be active response salinity tolerance wheat (Triticum aestivum), but participation latter this has not been established as yet. Here, salinity-responsive bread gene TaAOC1, which encodes an allene oxide cyclase pathway, was constitutively expressed both Arabidopsis (Arabidopsis thaliana). In species, transgenic lines...
<h3>Background & Aims</h3> Hepatocellular carcinoma (HCC) is one of the leading causes cancer-related deaths worldwide, but there a deficiency early diagnosis biomarkers and therapeutic targets. Drug resistance accounts for most HCC-related deaths, yet mechanisms underlying drug remain poorly understood. <h3>Methods</h3> Expression Frizzled-10 (FZD10) in liver cancer stem cells (CSCs) was identified by means RNA sequencing validated real-time polymerase chain reaction immunohistochemistry....
Circular RNAs (circRNAs) have been considered to mediate occurrence and development of human cancers, generally acting as microRNA (miRNA) sponges regulate downstream genes expression. However, the aberrant expression profile dysfunction circRNAs in bladder cancer remain be investigated. The present study aims elucidate potential role molecular mechanism circACVR2A regulating proliferation metastasis cancer. (hsa_circ_0001073) was identified by RNA-sequencing validated quantitative real-time...
With the development of RNA-seq technology, tens thousands circular RNAs (circRNAs), a novel class RNAs, have been identified. However, little is known about circRNA formation and biogenesis in hepatocellular carcinoma (HCC).We performed ribosomal-depleted profiling HCC para-carcinoma tissues analyzed expression hotspot derived from 3'UTR stearoyl-CoA desaturase (SCD) gene, termed SCD-circRNA 2.It was significantly upregulated correlated with poor patient prognosis. Moreover, we observed...
Increasing evidence has revealed that circular RNAs (circRNAs) play crucial roles in cancer biology. However, the role and underlying regulatory mechanisms of circFNDC3B bladder (BC) remain unknown. A cell invasion model was established by repeated transwell assays, invasion-related circRNAs BC were identified through an model. The expression detected 82 tissues lines quantitative real-time PCR. Functional assays performed to evaluate effects on proliferation, migration vitro-, tumorigenesis...
The 12-oxo-phytodienoic acid reductases (OPRs) are classified into the two subgroups OPRI and OPRII. latter proteins participate in jasmonic synthesis, while function of former ones is as yet unclear. We describe here characterization gene TaOPR1, isolated from salinity-tolerant bread wheat (Triticum aestivum) cultivar SR3. Salinity stress induced a higher level TaOPR1 expression seedling roots cv SR3 than its parental cultivar, JN177. This induction was abolished when abscisic (ABA)...
The coagulation protease activated protein C (aPC) confers cytoprotective effects in various vitro and vivo disease models, including diabetic nephropathy. nephroprotective effect may be related to antioxidant of aPC. However, the mechanism through which aPC convey these functional relevance properties remain unknown. Here, we show that endogenous exogenous prevents glomerular accumulation oxidative stress markers redox-regulating p66 Shc experimental These were predominately observed...
Abstract Background Circular RNAs (circRNAs) represent a subclass of regulatory that have been shown to significant roles in cancer progression. However, the biological functions circRNAs bladder (BCa) are largely unknown. Methods Cell invasion models were established, and invasion-related detected by qPCR. Using above method, circ- ZKSCAN1 was picked out for further study. Circ- expression survival analyses performed through The curves generated Kaplan-Meier log-rank test used assess...
Hepatitis B virus X (HBx) protein is implicated in hepatitis (HBV)–associated liver carcinogenesis. However, it remains unclear whether HBx–expressing hepatic progenitor cells (HPCs) are attributed to tumor formation. In this study, by using HBx transgenic mice and a 3,5–diethoxycarbonyl–1,4–dihydrocollidine (DDC)–induced injury model, the relationship between expression tumorigenicity of HPCs was analyzed. Compared with control mice, an elevated number EpCAM+ characteristics observed after...
Circ-BPTF (hsa_circ_0000799) is a novel circular RNA derived from BPTF exons.Although well-studied predecessor gene, the characteristics and functions of circ-BPTF have not yet been reported.Here, we show that expression increased in bladder cancer (BCa) tissues cell lines compared with noncancerous lines.Consistently, BCa patients higher levels were found to tumor grades poorer prognosis.Functionally, knockdown inhibited progression vitro vivo.Mechanistically, target microRNA was confirmed...
Hypoxia plays a critical role in cancer biology.It induces genomic instability, which turn helps cells respond adaptively to meet the needs of carcinogenesis, progression and relapse.Circular RNA has not been reported among variety downstream factors this adaptive response.Although few studies have demonstrated important circular RNAs driving human bladder progression, their carcinogenic roles are still under investigated.Here, we identified hypoxia-elevated RNA, circELP3, that contributes...
Timely liver function recovery (LFR) is crucial for postoperative hepatocellular carcinoma (HCC) patients. Here, we established the significance of LFR on patient long-term survival through retrospective and prospective cohorts identified a key gut microbe, Bifidobacterium longum, depleted in patients with delayed recovery. Fecal microbiota transfer from HCC to mice similarly impacted time post hepatectomy. However, oral gavage B. longum improved repair these mice. In clinical trial...
Pulmonary hypertension (PH) is a devastating disease characterized by irreversible pulmonary vascular remodeling (PVR) that causes right ventricular failure and death. The early alternative activation of macrophages critical event in the development PVR PH, but underlying mechanisms remain elusive. Previously we have shown N6-methyladenosine (m6A) modifications RNA contribute to phenotypic switching artery smooth muscle cells PH. In current study, identify Ythdf2, an m6A reader, as important...
Abstract Targeted drug delivery and the reduction of off‐target effects are crucial for promising clinical application nucleic acid drugs. To address this challenge, a new approach treating osteoarthritis (OA) that accurately delivers antisense oligonucleotides (ASO) targeting matrix metalloproteinase‐13 (ASO‐MMP13) to chondrocytes, is developed. Small extracellular vesicles (exos) ligated with chondrocyte affinity peptide (CAP) using Sortase A subsequently incubated cholesterol‐modified...
The arctic strain of Chlorella sp. (Chlorella-Arc) exists in the coldest and driest ecosystems, it is a new resource active polysaccharides. extraction crude polysaccharide from Chlorella-Arc was optimized using response surface methodology. A yield approximately 9.62 ± 0.11% dry weight obtained under these conditions. Three fractions (P-I, P-II, P-III) were present after purification by 2-diethylaminoethanol Sepharose Fast Flow Sephadex G-100 chromatography. P-IIa fraction demonstrated...
Colorectal cancer (CRC, also known as colon cancer, rectal or bowel cancer) is the second leading cause of mortality in Western world. MicroRNAs (miRNAs) are a class small (18-25 nucleotides long) noncoding RNAs with important posttranscriptional regulatory functions. miRNAs play roles various physiological and pathological processes including carcinogenesis solid cancers CRC. In order to investigate that played CRC, expression human (in 20 normal adjacent tissue samples samples) was...