A5055720103- Pain Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Diet and metabolism studies
- Advanced Glycation End Products research
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Chronic Kidney Disease and Diabetes
- Diabetes and associated disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Bariatric Surgery and Outcomes
- Acupuncture Treatment Research Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Peripheral Nerve Disorders
- Diabetes Management and Research
- Adipokines, Inflammation, and Metabolic Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Dietary Effects on Health
- Atherosclerosis and Cardiovascular Diseases
- Thermoregulation and physiological responses
- Cardiac Health and Mental Health
- Parkinson's Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
Heidelberg University
2016-2025
University Hospital Heidelberg
2016-2025
German Center for Diabetes Research
2017-2025
Heinrich Heine University Düsseldorf
2017-2025
Deutsches Diabetes-Zentrum e.V.
2017-2025
Helmholtz Zentrum München
2023-2024
Chirurgische Universitätsklinik Heidelberg
2015-2023
Heidelberg University
2007-2021
European Atherosclerosis Society
2021
Diabetes Australia
2021
Diabetic nephropathy is a growing health concern with characteristic sterile inflammation. As the underlying mechanisms of this inflammation remain poorly defined, specific therapies targeting in diabetic are lacking. Intriguingly, an association inflammasome activation has recently been shown, but pathophysiological relevance finding remains unknown. Within glomeruli, was detected endothelial cells and podocytes humans mice glucose-stressed glomerular vitro. Abolishing Nlrp3 or caspase-1...
OBJECTIVE To determine whether a mindfulness-based stress reduction (MBSR) intervention is effective for reducing psychosocial distress (i.e., depression, stress) and the progression of nephropathy albuminuria) improving subjective health status patients with type 2 diabetes. RESEARCH DESIGN AND METHODS Patients diabetes microalbuminuria were randomized to (n = 53) or treatment-as-usual control 57) group. The study designed investigate long-term outcomes over period 5 years. We present data...
Lifestyle intervention (LI) can prevent type 2 diabetes, but response to LI varies depending on risk subphenotypes. We tested whether individuals with prediabetes low (LR) benefit from conventional and high (HR) an intensification of in a multicenter randomized controlled over 12 months years’ follow-up. A total 1,105 based American Diabetes Association glucose criteria were stratified into HR or LR phenotype previously described thresholds insulin secretion, sensitivity, liver fat content....
Abstract A major obstacle in diabetes is the metabolic or hyperglycemic memory, which lacks specific therapies. Here we show that glucose-mediated changes gene expression largely persist diabetic kidney disease (DKD) despite reversing hyperglycemia. The senescence-associated cyclin-dependent kinase inhibitor p21 ( Cdkn1a ) was top hit among genes persistently induced by hyperglycemia and associated with induction of p53-p21 pathway. Persistent confirmed various animal models, human samples...
Abstract Context Novel fasting interventions have gained scientific and public attention. Periodic has emerged as a dietary modification promoting beneficial effects on metabolic syndrome. Objective Assess whether periodic reduces albuminuria activates nephropathy-driven pathways. Design/Participants Proof-of-concept study where individuals with type 2 diabetes (n = 40) increased albumin-to-creatinine ratio (ACR) were randomly assigned to receive monthly fasting-mimicking diet (FMD) or...
Abstract Background Total circulating soluble receptor for advanced glycation endproducts (sRAGE) and a more defined endogenous secretory splice variant of the (esRAGE) were shown to be associated with different markers cardiovascular risk in patients diabetes. Since previous data partly divergent, aim this study was compare sRAGE esRAGE head-to-head analysis type 2 diabetes (T2DM) albuminuria. Methods studied plasma 110 T2DM using enzyme-linked immunosorbant assays (ELISA) detecting either...
Objective To visualize and quantify differences of microstructural nerve damage in distal symmetric diabetic neuropathy (DPN) between type 1 diabetes (T1D) 2 (T2D), to detect correlations neuropathic symptoms serological risk factors. Methods Three‐tesla magnetic resonance neurography the sciatic was performed 120 patients (T1D, n = 35; T2D, 85) with either DPN (n 84) or no 36). Results were subsequently correlated clinical, serological, electrophysiological patient data. T2‐weighted...
The deficit of Glyoxalase I (Glo1) and the subsequent increase in methylglyoxal (MG) has been reported to be one five mechanisms by which hyperglycemia causes diabetic late complications. Aldo-keto reductases (AKR) have shown metabolize MG; however, relative contribution this superfamily detoxification MG vivo, particularly within state, remains unknown. CRISPR/Cas9-mediated genome editing was used generate a Glo1 knock-out (Glo1−/−) mouse line. Streptozotocin then applied investigate...
The number of diabetic patients in Europe and world-wide is growing. Diabetes confers a two-fold higher risk for vascular disease. Lack insulin production (T1D) or lack responsiveness (T2D) causes systemic metabolic changes such as hyperglycemia (HG) which contribute to the pathology diabetes. Monocytes macrophages are key innate immune cells that control inflammatory reactions associated with complications. Inflammatory programming regulated maintained by epigenetic mechanisms, particular...
The individual risk of progression diabetic peripheral neuropathy is difficult to predict for each individual. Mutations in proteins that are responsible the process myelination known cause neurodegeneration and display alteration experimental models neuropathy. In a prospective observational human pilot study, we investigated myelin-specific circulating mRNA targets, which have been identified vitro, their capacity diagnosis prediction most promising candidate was tested against recently...
Due to the heterogenous clinical symptoms and deficits, diagnosis of diabetic polyneuropathy (DPN) is still difficult in routines, leading increased morbidity mortality.
The effect of metformin on methylglyoxal (MG) metabolism was studied in a prospective non-randomized 24 weeks trial patients with type 2 diabetes. Metformin treatment, addition to life style intervention, significantly reduced morning glucose and HbA<sub>1c</sub> whilst body weight BMI were only marginally during the week trial. Treatment both plasma MG carboxymethyl-lysine (CML), marker oxidative stress. reduction paralleled by significant increase activity Glyoxalase 1 (Glo1), major route...
Diabetes mellitus is a significant comorbidity of interstitial lung disease (ILD).The aim this study was to investigate the incidence restrictive (RLD) and ILD in patients with prediabetes type 2 diabetes (T2D).Forty-eight nondiabetics, 68 prediabetes, 29 newly diagnosed T2D, 110 long-term T2D were examined for metabolic control, diabetes-related complications, breathlessness, function. Five participants RLD underwent multidetector computed tomography (MDCT) Six-Minute Walk Test (6MWT). Lung...
<h3>Importance</h3> Lowering serum cholesterol levels is a well-established treatment for dyslipidemia in patients with type 2 diabetes (T2D). However, nerve lesions T2D increase lower levels, suggesting that lowering associated diabetic polyneuropathy (DPN) T2D. <h3>Objective</h3> To investigate whether there an association between and peripheral without DPN. <h3>Design, Setting, Participants</h3> This single-center, cross-sectional, prospective cohort study was performed from June 1, 2015,...
<b><i>Background:</i></b> Diabetes mellitus is a possible risk factor for the development of idiopathic pulmonary fibrosis (IPF), yet effect antidiabetic therapy on course IPF unknown. <b><i>Objectives:</i></b> This post hoc analysis assessed metformin clinically relevant outcomes in patients with IPF. <b><i>Methods:</i></b> For primary analysis, randomized to placebo (<i>n</i> = 624) 3 phase 3, double-blind,...
Increased methylglyoxal (MG) formation is associated with diabetes and its complications. In zebrafish, knockout of the main MG detoxifying system Glyoxalase 1, led to limited elevation but significantly elevated aldehyde dehydrogenases (ALDH) activity aldh3a1 expression, suggesting compensatory role Aldh3a1 in diabetes. To evaluate function glucose homeostasis diabetes, aldh3a1−/− zebrafish mutants were generated using CRISPR-Cas9. Vasculature pancreas morphology analysed by transgenic...
Abstract Background Cardiovascular risk management is beneficial, but stringent glycemic control does not prevent the progression of distal sensorimotor polyneuropathy (DSPN). Persistent hyperglycemia-induced alterations and cardiovascular factors may contribute to diabetes-associated nerve damage. This study aimed evaluate correlation between skin auto-fluorescence (sAF), an indicator dermal advanced glycation end-product (AGE) accumulations, risk, changes in peripheral integrity. Methods...