A5054433148- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Diabetes Management and Research
- Regulation of Appetite and Obesity
- Adipokines, Inflammation, and Metabolic Diseases
- Genetic Associations and Epidemiology
- Diabetes and associated disorders
- Gestational Diabetes Research and Management
- Cardiovascular Disease and Adiposity
- Lipid metabolism and biosynthesis
- Lipid metabolism and disorders
- Nutrition, Genetics, and Disease
- Heart Rate Variability and Autonomic Control
- Botulinum Toxin and Related Neurological Disorders
- Neurological and metabolic disorders
- Obesity, Physical Activity, Diet
- Prostate Cancer Treatment and Research
- Folate and B Vitamins Research
- Breastfeeding Practices and Influences
University Children's Hospital Tübingen
2008-2024
German Center for Diabetes Research
2013-2024
Heinrich Heine University Düsseldorf
2013-2024
Deutsches Diabetes-Zentrum e.V.
2013-2024
University of Tübingen
2013-2024
Helmholtz Zentrum München
2022-2024
Universitätsklinikum Tübingen
2006-2023
Institute of Diabetes Research
2017-2023
Weatherford College
2008
Deutsche Gesellschaft für Urologie
2005
OBJECTIVE In a genome-wide association scan, the rs738409 C>G single nucleotide polymorphism (SNP) in patatin-like phospholipase 3 gene (PNPLA3) was strongly associated with increased liver fat but not insulin resistance estimated from fasting values. We investigated whether SNP determines independently of visceral adiposity and it may even play role protecting resistance. RESEARCH DESIGN AND METHODS Liver measured by 1H magnetic resonance spectroscopy total tomography 330 subjects....
OBJECTIVE To evaluate whether the sodium–glucose cotransporter 2 inhibitor empagliflozin (EMPA) reduces liver fat content (LFC) in recent-onset and metabolically well-controlled type diabetes (T2D). RESEARCH DESIGN AND METHODS Patients with T2D (n = 84) (HbA1c 6.6 ± 0.5% [49 10 mmol/mol], known disease duration 39 27 months) were randomly assigned to 24 weeks of treatment 25 mg daily EMPA or placebo. The primary end point was difference change LFC as measured magnetic resonance methods from...
To investigate the effect of normalizing vitamin B12 (B12) levels with oral (methylcobalamin) 1000 μg/day for one year in patients diabetic neuropathy (DN). In this prospective, double-blind, placebo-controlled trial, 90 type 2 diabetes on metformin at least four years and both peripheral autonomic DN were randomized to an active treatment group (n = 44) receiving a control 46) placebo. All had less than 400 pmol/L. Subjects underwent measurements sural nerve conduction velocity (SNCV),...
<h3>Objective:</h3> Lifestyle intervention with diet modification and increase in physical activity is effective for reducing hepatic steatosis patients non-alcoholic fatty liver disease (NAFLD). However, a similar weight loss, there large variability the change fat. We hypothesised that cardiorespiratory fitness may predict response to intervention. <h3>Design:</h3> Longitudinal study modification. <h3>Setting:</h3> University teaching hospital. <h3>Patients:</h3> 50 adults NAFLD 120...
Type 2 diabetes arises when insulin resistance-induced compensatory secretion exhausts. Insulin resistance and/or beta-cell dysfunction result from the interaction of environmental factors (high-caloric diet and reduced physical activity) with a predisposing polygenic background. Very recently, genetic variations within four novel loci (SLC30A8, HHEX, EXT2, LOC387761) were reported to be more frequent in subjects type than healthy controls. However, associations these not assessed.By...
OBJECTIVE We investigated whether palmitoleate, which prevents insulin resistance in mice, predicts sensitivity humans. RESEARCH DESIGN AND METHODS The fasting fatty acid pattern the plasma free (FFA) fraction was determined 100 subjects at increased risk for type 2 diabetes. Insulin estimated during an oral glucose tolerance test (OGTT) baseline and after 9 months of lifestyle intervention measured euglycemic-hyperinsulinemic clamp (n = 79). RESULTS Circulating palmitoleate (OGTT:F ratio...
OBJECTIVE Recent data suggested that sex hormone–binding globulin (SHBG) levels decrease when fat accumulates in the liver and circulating SHBG may be causally involved pathogenesis of type 2 diabetes humans. In present study, we investigated mechanisms by which high prevent development to diabetes. RESEARCH DESIGN AND METHODS Before during a 9-month lifestyle intervention, total body visceral were precisely measured magnetic resonance (MR) tomography was 1H-MR spectroscopy 225 subjects....
Nonalcoholic fatty liver (NAFL) is thought to contribute insulin resistance and its metabolic complications. However, some individuals with NAFL remain sensitive. Mechanisms involved in the susceptibility develop humans are largely unknown. We investigated circulating markers mechanisms of a metabolically benign malignant by applying metabolomic approach.A total 265 metabolites were analyzed before after 9-month lifestyle intervention plasma from 20 insulin-sensitive insulin-resistant...
OBJECTIVE Insulin action in the human brain reduces food intake, improves whole-body insulin sensitivity, and modulates body fat mass its distribution. Obesity type 2 diabetes are often associated with resistance, resulting impaired brain-derived modulation of peripheral metabolism. So far, no pharmacological treatment for resistance has been established. Since sodium–glucose cotransporter (SGLT2) inhibitors lower glucose levels modulate energy metabolism, we hypothesized that SGLT2...
Lifestyle intervention (LI) can prevent type 2 diabetes, but response to LI varies depending on risk subphenotypes. We tested whether individuals with prediabetes low (LR) benefit from conventional and high (HR) an intensification of in a multicenter randomized controlled over 12 months years’ follow-up. A total 1,105 based American Diabetes Association glucose criteria were stratified into HR or LR phenotype previously described thresholds insulin secretion, sensitivity, liver fat content....
Abstract Objective: High visceral adipose tissue (VAT) and high liver fat (LF) are associated with the metabolic syndrome diabetes. We studied changes in these two depots during weight loss analyzed whether VAT LF at baseline predict response to lifestyle intervention. Research Methods Procedures: One hundred twelve subjects (48 men 64 women; age, 46 ± 11 years; BMI, 29.2 4.4 kg/m 2 ) were after a follow up‐time of 264 60 (SD) days. Insulin sensitivity was estimated from oral glucose...
Very recently, a novel type 2 diabetes risk gene, i.e., MTNR1B, was identified and reported to affect fasting glycemia. Using our thoroughly phenotyped cohort of subjects at an increased for diabetes, we assessed the association common genetic variation within MTNR1B locus with obesity prediabetes traits, namely impaired insulin secretion resistance.We genotyped 1,578 non-diabetic subjects, metabolically characterized by oral glucose tolerance test, five tagging single nucleotide...
Purpose To assess adipose body compartments with magnetic resonance (MR) imaging and MR spectroscopy during a lifestyle intervention program that included optimized nutrition controlled physical activity in subjects at increased risk for type 2 diabetes to determine factors may help predict an increase insulin sensitivity following the intervention. Materials Methods This prospective study was approved by local review board. All participants gave written informed consent. were performed 243...
Abstract Background Lifestyle intervention is effective in the prevention of type 2 diabetes individuals with impaired glucose tolerance (IGT). It currently unknown whether it has beneficial effects on metabolism to a similar extent, normal (NGT) compared IGT. Materials and methods Data from 181 subjects (133 NGT at risk for 48 IGT) who participated Tuebingen Intervention Program increase physical activity decrease caloric intake were included into this study. Body fat distribution was...
OBJECTIVE KCNQ1 gene polymorphisms are associated with type 2 diabetes. This linkage appears to be mediated by altered β-cell function. In an attempt study underlying mechanisms, we examined the effect of four single nucleotide (SNPs) on insulin secretion upon different stimuli. RESEARCH DESIGN AND METHODS We genotyped 1,578 nondiabetic subjects at increased risk diabetes for rs151290, rs2237892, rs2237895, and rs2237897. All participants underwent oral glucose tolerance test (OGTT);...
We performed the largest randomized, placebo‐controlled clinical trial to date (N = 112, 12‐week intervention) investigate effects and safety of resveratrol supplementation on liver fat content cardiometabolic risk parameters in overweight obese insulin‐resistant subjects. At baseline variability was very large, ranging from 0.09% 37.55% (median, 7.12%; interquartile range, 3.85%‐12.94%). Mean (SD) 9.22 (6.85) % placebo group 9.91 (7.76) group. During study decreased (−0.7%) but not (−0.03%)...
The metabolic effects of adiponectin, including insulin sensitivity, seem to become stronger with increasing adiposity. Adiposity may also affect the relationship adiponectin concentrations serum lipid profile; markers inflammation, atherosclerosis, and endothelial function; ectopic fat accumulation.We measured plasma concentrations, lipids, function in 242 Caucasians without type 2 diabetes. We visceral adipose tissue magnetic resonance tomography liver intramyocellular (1)H spectroscopy.We...
The enzyme DGAT (acyl-CoA:diacylglycerol acyltransferase) catalyses the final step of triacylglycerol (triglyceride) synthesis. Mice overexpressing hepatic DGAT2 fed a high-fat diet develop fatty liver, but not insulin resistance, suggesting that induces dissociation between liver and resistance. In present study, we investigated whether such phenotype also exists in humans. For this purpose, determined relationships genetic variability gene with changes fat sensitivity 187 extensively...
Aim: To investigate the efficacy of Superoxide Dismutase, Alpha Lipoic Acid, Acetyl L-Carnitine, and Vitamin B12 (B12) in one tablet Diabetic Neuropathy (DN). Patients–methods: In this prospective, double-blind, placebo-controlled study, 85 patients with Diabetes Mellitus Type 2 (DMT2) were randomly assigned, either to receive combination four elements (active group, n = 43), or placebo (n 42) for 12 months. We used Michigan Screening Instrument Questionnaire Examination (MNSIQ MNSIE),...