A5004985151- Photoacoustic and Ultrasonic Imaging
- Cerebrovascular and Carotid Artery Diseases
- Liver Disease Diagnosis and Treatment
- Retinal Diseases and Treatments
- Optical Imaging and Spectroscopy Techniques
- Optical Coherence Tomography Applications
- Non-Invasive Vital Sign Monitoring
- Retinal Imaging and Analysis
- Diet and metabolism studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Disease Prevention
Helmholtz Zentrum München
2023-2024
Institute of Biological and Medical Imaging
2023-2024
Technical University of Munich
2023-2024
Skin microangiopathy has been associated with diabetes. Here we show that skin-microangiopathy phenotypes in humans can be correlated diabetes stage via morphophysiological cutaneous features extracted from raster-scan optoacoustic mesoscopy (RSOM) images of skin on the leg. We obtained 199 RSOM 115 participants (40 healthy and 75 diabetes), used machine learning to segment layers microvasculature identify clinically explainable pertaining different depths scales detail provided highest...
Hepatic steatosis is characterized by intrahepatic lipid accumulation and may lead to irreversible liver damage if untreated. Here, we investigate whether multispectral optoacoustic tomography (MSOT) can offer label-free detection of content enable non-invasive characterization hepatic analyzing the spectral region around 930 nm, where lipids characteristically absorb. In a pilot study, apply MSOT measure surrounding tissues in five patients with healthy volunteers, revealing significantly...
Imaging skeletal muscle function and metabolism, as reported by local hemodynamics oxygen kinetics, can elucidate performance, severity of an underlying disease or outcome a treatment. Herein, we used multispectral optoacoustic tomography (MSOT) to image kinetics within during exercise. Four healthy volunteers underwent three different hand-grip exercise challenges (60s isometric, 120s intermittent isometric 60s isotonic). During contraction, MSOT showed decrease HbO2, Hb total blood volume...
Microvascular endothelial dysfunction may provide insights into systemic diseases, such as carotid artery disease. Raster-scan optoacoustic mesoscopy (RSOM) can produce images of skin microvasculature during challenges via numerous microvascular features. Herein, RSOM was employed to image the 26 subjects (13 patients with single disease, 13 healthy participants) assess dynamics 18 features at three scales detail, i.e., micro- (<100 μm), meso- (≈100-1000 μm) and macroscale (<1000...