A5010961147- Gestational Diabetes Research and Management
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Diabetes Treatment and Management
- Regulation of Appetite and Obesity
- Pancreatic function and diabetes
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Research
- Nutrition, Genetics, and Disease
- Exercise and Physiological Responses
- Bariatric Surgery and Outcomes
- Liver Disease Diagnosis and Treatment
- Pharmacology and Obesity Treatment
- Diabetes Management and Education
- Diet, Metabolism, and Disease
- Cardiovascular Disease and Adiposity
- Breastfeeding Practices and Influences
- Genetic Associations and Epidemiology
- Metabolomics and Mass Spectrometry Studies
- Obesity, Physical Activity, Diet
- Hormonal and reproductive studies
German Center for Diabetes Research
2016-2025
University of Tübingen
2016-2025
Heinrich Heine University Düsseldorf
2016-2025
Deutsches Diabetes-Zentrum e.V.
2016-2025
University Children's Hospital Tübingen
2013-2024
Helmholtz Zentrum München
2018-2024
Universitätsklinikum Tübingen
2009-2023
Institute of Diabetes Research
2016-2023
University Hospital of Bern
2021
University of Bern
2021
Increased hepatic expression of dipeptidyl peptidase 4 (DPP4) is associated with non-alcoholic fatty liver disease (NAFLD). Whether this causative for the development NAFLD not yet clarified. Here we investigate effect DPP4 overexpression on steatosis in a mouse model diet-induced obesity.
OBJECTIVE Insulin action in the human brain reduces food intake, improves whole-body insulin sensitivity, and modulates body fat mass its distribution. Obesity type 2 diabetes are often associated with resistance, resulting impaired brain-derived modulation of peripheral metabolism. So far, no pharmacological treatment for resistance has been established. Since sodium–glucose cotransporter (SGLT2) inhibitors lower glucose levels modulate energy metabolism, we hypothesized that SGLT2...
Lifestyle intervention (LI) can prevent type 2 diabetes, but response to LI varies depending on risk subphenotypes. We tested whether individuals with prediabetes low (LR) benefit from conventional and high (HR) an intensification of in a multicenter randomized controlled over 12 months years’ follow-up. A total 1,105 based American Diabetes Association glucose criteria were stratified into HR or LR phenotype previously described thresholds insulin secretion, sensitivity, liver fat content....
BACKGROUNDInsulin resistance of the brain can unfavorably affect long-term weight maintenance and body fat distribution. Little is known if how insulin sensitivity be restored in humans. We aimed to evaluate effects an exercise intervention on this relates exercise-induced changes whole-body metabolism behavior.METHODSIn clinical trial, sedentary participants who were overweight obese underwent 8-week supervised aerobic training intervention. Brain was assessed 21 (14 women, 7 men; age range...
ABSTRACT Background and Aims While low plasma butyrylcholinesterase (BChE) is a well‐established marker of reduced liver synthesis capacity, the clinical significance elevated BChE unclear. In small studies, high has long been suspected in hepatic steatosis metabolic syndrome. We aimed to clarify relation between BChE, fat glucose metabolism deeply phenotyped cohorts. Methods Plasma activity was measured 844 humans (554 women) cross‐sectional Tübingen Diabetes Family Study, with wide BMI...
We performed the largest randomized, placebo‐controlled clinical trial to date (N = 112, 12‐week intervention) investigate effects and safety of resveratrol supplementation on liver fat content cardiometabolic risk parameters in overweight obese insulin‐resistant subjects. At baseline variability was very large, ranging from 0.09% 37.55% (median, 7.12%; interquartile range, 3.85%‐12.94%). Mean (SD) 9.22 (6.85) % placebo group 9.91 (7.76) group. During study decreased (−0.7%) but not (−0.03%)...
Insulin action in the human brain modulates eating behaviour, whole-body metabolism and body fat distribution1,2. In particular, insulin increases sensitivity, but these studies were mainly performed lean men3,4. Here we investigate metabolic hypothalamic effects of women with a focus on impact menstrual cycle ( ClinicalTrials.gov registration: NCT03929419 ).Eleven underwent four hyperinsulinemic-euglycemic clamps, two follicular phase luteal phase. Brain was introduced using nasal spray5-7...
Exercise exerts many health benefits by directly inducing molecular alterations in physically utilized skeletal muscle. Molecular adaptations of subcutaneous adipose tissue (SCAT) might also contribute to the prevention metabolic diseases.To characterize response human SCAT based on changes transcripts and mitochondrial respiration acute repeated bouts exercise comparison muscle.Sedentary participants (27 ± 4 yrs) with overweight or obesity underwent 8-week supervised endurance 3×1h/week at...
Gestational diabetes (GDM) influences the fetal phenotype.In present study, our aim was to determine effect of GDM specifically on brain activity.Pregnant participants underwent an oral glucose tolerance test (OGTT, 75 g). At 0, 60, and 120 minutes, maternal metabolism determined, auditory evoked fields were recorded with a magnetoencephalographic device.All measurements performed at fMEG Center in Tübingen.Twelve women 28 normal glucose-tolerant (NGT) pregnant participated voluntary...
Abstract The number of pregnancies complicated by gestational diabetes (GDM) is increasing worldwide. To identify novel characteristics GDM, we studied miRNA profiles maternal and fetal whole blood cells (WBCs) from GDM normal glucose tolerant (NGT) pregnant women matched for body mass index age. After adjustment weight gain pregnancy week, identified 29 mature micro-RNAs (miRNAs) up-regulated in one which, i.e., miRNA-340, was validated qPCR. mRNA protein expression PAIP1, a miRNA-340...
Abstract Background/Objectives Central insulin action influences cognitive processes, peripheral metabolism, and eating behavior. However, the contribution of obesity sex on central insulin-mediated neural food cue processing still remains unclear. Subjects/Methods In a randomized within-participant design, including two visits, 60 participants (30 women, BMI 18–32 kg/m 2 , age 21–69 years) underwent functional MRI task measuring blood oxygen level-dependent (BOLD) signal in response to...
Abstract Context Incretins are crucial stimulators of insulin secretion following food intake. Data on incretin and action during pregnancy sparse. Objective The aim the study was to investigate response an oral glucose tolerance test (OGTT) in pregnant women with without gestational diabetes mellitus (GDM). Design We analyzed data from ongoing observational PREG (NCT 04270578). Setting conducted at University Hospital Tübingen. Participants examined 167 (33 GDM) week 27 ± 2.2. Intervention...
Recently, alterations in maternal lipid metabolism were associated with gestational diabetes mellitus (GDM). However, detailed plasma profiles and their relevance for placental fetal are currently not understood.Maternal characterized women GDM normal glucose tolerance (NGT). Inflammatory gene expression was compared placentas primary term trophoblasts between the groups. In addition, stimulated nonesterified fatty acids (NEFAs), effects on quantified. Finally, macrophage content cord blood...
Objective Gestational diabetes mellitus (GDM) potentially harms the child before birth. We previously found GDM to be associated with developmental changes in central nervous system. now hypothesise that may also impact on fetal autonomic system under metabolic stress like an oral glucose tolerance test (OGTT). Design measured heart rate variability (HRV) of mothers and fetuses during a three‐point OGTT using magnetocardiography (fMCG). Setting Measurements were performed fMEG Centre...
OBJECTIVE Bariatric surgery is an effective treatment option for individuals with obesity and type 2 diabetes (T2D). However, whether outcomes in subtypes of at risk T2D and/or comorbidities (Tübingen Clusters) differ, unknown. Of these, cluster 5 (C5) 6 (C6) are high-risk clusters developing comorbidities, while 4 (C4) a low-risk cluster. We investigated bariatric outcomes, hypothesizing that benefit most due to great potential metabolic improvement. RESEARCH DESIGN AND METHODS allocated...
<p dir="ltr">Objective</p><p dir="ltr">Bariatric surgery (BS) is an effective treatment option for individuals with obesity and type 2 diabetes (T2D). However, whether outcomes in subtypes of at risk T2D and/or comorbidities (Tübingen Clusters) differ, unknown. Of these, clusters 5 6 (C5, C6) are high-risk developing comorbidities, while cluster 4 (C4) a low-risk cluster. We investigated BS outcomes, hypothesizing benefit most due to great potential metabolic...
<p dir="ltr">Objective</p><p dir="ltr">Bariatric surgery (BS) is an effective treatment option for individuals with obesity and type 2 diabetes (T2D). However, whether outcomes in subtypes of at risk T2D and/or comorbidities (Tübingen Clusters) differ, unknown. Of these, clusters 5 6 (C5, C6) are high-risk developing comorbidities, while cluster 4 (C4) a low-risk cluster. We investigated BS outcomes, hypothesizing benefit most due to great potential metabolic...
<p dir="ltr">Objective</p><p dir="ltr">Bariatric surgery (BS) is an effective treatment option for individuals with obesity and type 2 diabetes (T2D). However, whether outcomes in subtypes of at risk T2D and/or comorbidities (Tübingen Clusters) differ, unknown. Of these, clusters 5 6 (C5, C6) are high-risk developing comorbidities, while cluster 4 (C4) a low-risk cluster. We investigated BS outcomes, hypothesizing benefit most due to great potential metabolic...
The identity of specific serine phosphorylation residues insulin receptor substrate (IRS)-2 and their impact on signal transduction are largely unknown. Ser(675) Ser(907) mouse IRS-2 adjacent to PI 3-kinase or Grb2 binding domains, respectively. Using monoclonal phosphosite-specific antibodies, we demonstrated the both serines after stimulation Fao hepatoma cells with insulin, anisomycin, phorbol esters. Phosphorylation sites was a late prolonged event during treatment also detected in liver...
Nonadherence to standard operating procedures (SOPs) during handling and processing of whole blood is one the most frequent causes affecting quality serum plasma. Yet, samples utmost importance for reliable, conclusive research findings, valid diagnostics, appropriate therapeutic decisions.UHPLC-MS-driven nontargeted metabolomics was applied identify biomarkers that reflected time samples, a targeted UHPLC-MS analysis used quantify validate these biomarkers.We found...