A5057177496- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Metabolism, Diabetes, and Cancer
- Nutrition, Genetics, and Disease
- Liver Disease Diagnosis and Treatment
- Dietary Effects on Health
- Nutritional Studies and Diet
- Diabetes Treatment and Management
- Digestive system and related health
- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Diabetes and associated disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Research
- Regulation of Appetite and Obesity
- Obesity, Physical Activity, Diet
- Eating Disorders and Behaviors
- Biochemical Analysis and Sensing Techniques
- Consumer Attitudes and Food Labeling
- Adipokines, Inflammation, and Metabolic Diseases
- Growth Hormone and Insulin-like Growth Factors
- Metabolomics and Mass Spectrometry Studies
- Consumer behavior in food and health
- Hormonal Regulation and Hypertension
- Blood disorders and treatments
Deutsches Diabetes-Zentrum e.V.
2017-2025
Charité - Universitätsmedizin Berlin
2017-2025
Helmholtz Zentrum München
2018-2025
German Center for Diabetes Research
2017-2025
Heinrich Heine University Düsseldorf
2017-2025
German Institute of Human Nutrition
2015-2024
Humboldt-Universität zu Berlin
2021-2024
Freie Universität Berlin
2021-2024
Phoenix Contact (Germany)
2024
Hochschule Düsseldorf University of Applied Sciences
2024
OBJECTIVE To evaluate whether the sodium–glucose cotransporter 2 inhibitor empagliflozin (EMPA) reduces liver fat content (LFC) in recent-onset and metabolically well-controlled type diabetes (T2D). RESEARCH DESIGN AND METHODS Patients with T2D (n = 84) (HbA1c 6.6 ± 0.5% [49 10 mmol/mol], known disease duration 39 27 months) were randomly assigned to 24 weeks of treatment 25 mg daily EMPA or placebo. The primary end point was difference change LFC as measured magnetic resonance methods from...
Gender differences in the regulation of body weight are well documented. Here, we assessed obesity-related influences gender on brain structure as performance Iowa Gambling Task. This task requires evaluation both immediate rewards and long-term outcomes thus mirrors trade-off between reward from eating effect overeating weight. In women, but not men, show that preference for salient face negative consequences is higher obese than lean subjects. addition, report structural left dorsal...
Lifestyle intervention (LI) can prevent type 2 diabetes, but response to LI varies depending on risk subphenotypes. We tested whether individuals with prediabetes low (LR) benefit from conventional and high (HR) an intensification of in a multicenter randomized controlled over 12 months years’ follow-up. A total 1,105 based American Diabetes Association glucose criteria were stratified into HR or LR phenotype previously described thresholds insulin secretion, sensitivity, liver fat content....
OBJECTIVE Progression of prediabetes to type 2 diabetes has been associated with β-cell dysfunction, whereas its remission normoglycemia related improvement insulin sensitivity. To understand the mechanisms and identify potential biomarkers trajectories, we compared proteomics metabolomics profile people progressing or reversing within 1 year. RESEARCH DESIGN AND METHODS The fasting plasma concentrations 1,389 proteins fasting, 30-min, 120-min post–oral glucose tolerance test (OGTT) 152...
Glucagon-like peptide-1 receptor agonists such as exenatide are known to influence neural activity in the hypothalamus of animals and reduce energy intake. In humans, however, significant weight loss has been observed only a subgroup patients. Why some individuals respond with others do not remains unclear. this functional magnetic resonance imaging (fMRI) study, we investigated differences hypothalamic connectivity between "responders" (reduction intake after infusion) "nonresponders."We...
Abstract Background and aims Non‐alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent nutrition intervention remains the most important therapeutic approach for NAFLD. Our aim was to investigate whether low‐ (LP) or high‐protein (HP) diets are more effective in reducing fat reversing NAFLD which mechanisms involved. Methods 19 participants with morbid obesity undergoing bariatric surgery were randomized into two hypocaloric (1500‐1600 kcal/day) diet groups, a low protein...
Angiotensin-converting enzyme (ACE) plays a major role in blood pressure regulation and cardiovascular homeostasis. Contrary to the assumption that ACE levels are stable, circulating has been shown be altered obesity weight loss. We sought examine effects of high-saturated-fat (HF) diet on within NUtriGenomic Analysis Twins (NUGAT) study.Forty-six healthy nonobese twin pairs initially consumed carbohydrate-rich, low-fat over period 6 weeks standardize for nutritional behavior prior study,...
Reduction of brain glucose transporter GLUT1 results in severe neurological dysfunction. VEGF is required to restore and maintain uptake across the blood barrier via GLUT1, which was shown be acutely diminished response a high fat diet (HFD) mice. The genetic HFD-related regulation association (SLC2A1) humans investigated NUtriGenomic Analysis Twins (NUGAT) study. 92 healthy non-obese twins were standardized high-carbohydrate low-fat for 6 weeks before switched 6-week HFD under isocaloric...
Insoluble cereal fibres have been shown in large prospective cohort studies to be highly effective preventing type 2 diabetes, but there is a lack of interventional data. Our year randomised double-blind intervention study compared the effect an insoluble oat fibre extract with that placebo on glucose metabolism and incidence diabetes. A total 180 participants impaired tolerance underwent modified version 1 lifestyle training programme PREvention DIAbetes Self-management (PREDIAS) were...
Obesity is associated with genetic and environmental factors but the underlying mechanisms remain poorly understood. Recent genome-wide association studies (GWAS) identified obesity- type 2 diabetes-associated variants located within or near genes that modulate brain activity development. Among top hits rs17782313 MC4R, encoding for melanocortin-4-receptor, which expressed in regions regulate eating. Here, we hypothesized rs17782313-associated changes human eating behavior. Therefore,...
High intake of cereal fibre is associated with reduced risk for type 2 diabetes and long-term complications. Within the first randomized controlled trial specifically targeting fibre, Optimal Fibre Trial (OptiFiT), insoluble oat was shown to significantly reduce glycaemia. Previous studies suggested that this effect might be limited subjects impaired fasting glucose (IFG).We stratified OptiFiT cohort normal (NFG, IFG) conducted a secondary analysis comparing effects supplementation between...
<p dir="ltr">Objective: Progression of prediabetes to type 2 diabetes has been associated with beta cell dysfunction, whereas its remission normoglycemia related improvement insulin sensitivity. To understand the mechanisms and identify potential biomarkers trajectories, we compared proteomics metabolomics profile people progressing or reversing within a year. </p><p dir="ltr">Research Design Methods: The fasting plasma concentrations 1389 proteins fasting, 30 min 120...
<p dir="ltr">Objective: Progression of prediabetes to type 2 diabetes has been associated with beta cell dysfunction, whereas its remission normoglycemia related improvement insulin sensitivity. To understand the mechanisms and identify potential biomarkers trajectories, we compared proteomics metabolomics profile people progressing or reversing within a year. </p><p dir="ltr">Research Design Methods: The fasting plasma concentrations 1389 proteins fasting, 30 min 120...