A5010445462- Diabetes Treatment and Management
- Regulation of Appetite and Obesity
- Gestational Diabetes Research and Management
- Pancreatic function and diabetes
- Diet and metabolism studies
- Health and Medical Studies
- Birth, Development, and Health
- School Health and Nursing Education
- Child and Adolescent Health
- Pregnancy and preeclampsia studies
- Pancreatitis Pathology and Treatment
- Diabetes Management and Education
- Metabolism, Diabetes, and Cancer
- Health Policy Implementation Science
- Advanced Fluorescence Microscopy Techniques
- Neurological Disorders and Treatments
- Heart Rate Variability and Autonomic Control
- Hypothalamic control of reproductive hormones
- Biochemical effects in animals
- Childhood Cancer Survivors' Quality of Life
- Extracellular vesicles in disease
- Adipose Tissue and Metabolism
- Adolescent and Pediatric Healthcare
- Cardiovascular Disease and Adiposity
- Bariatric Surgery and Outcomes
Ludwig-Maximilians-Universität München
2001-2024
University Hospital Ulm
2022-2024
Zimmer Biomet (Germany)
2023-2024
University of Tübingen
2021-2023
German Center for Diabetes Research
2019-2023
Universität Ulm
2022-2023
Helmholtz Zentrum München
2022
Institute of Diabetes Research
2019-2022
Heinrich Heine University Düsseldorf
2021-2022
Deutsches Diabetes-Zentrum e.V.
2021-2022
OBJECTIVE Insulin action in the human brain reduces food intake, improves whole-body insulin sensitivity, and modulates body fat mass its distribution. Obesity type 2 diabetes are often associated with resistance, resulting impaired brain-derived modulation of peripheral metabolism. So far, no pharmacological treatment for resistance has been established. Since sodium–glucose cotransporter (SGLT2) inhibitors lower glucose levels modulate energy metabolism, we hypothesized that SGLT2...
Insulin action in the human brain modulates eating behaviour, whole-body metabolism and body fat distribution1,2. In particular, insulin increases sensitivity, but these studies were mainly performed lean men3,4. Here we investigate metabolic hypothalamic effects of women with a focus on impact menstrual cycle ( ClinicalTrials.gov registration: NCT03929419 ).Eleven underwent four hyperinsulinemic-euglycemic clamps, two follicular phase luteal phase. Brain was introduced using nasal spray5-7...
Abstract Context Incretins are crucial stimulators of insulin secretion following food intake. Data on incretin and action during pregnancy sparse. Objective The aim the study was to investigate response an oral glucose tolerance test (OGTT) in pregnant women with without gestational diabetes mellitus (GDM). Design We analyzed data from ongoing observational PREG (NCT 04270578). Setting conducted at University Hospital Tübingen. Participants examined 167 (33 GDM) week 27 ± 2.2. Intervention...
Abstract Context Pharmacological lowering of low-density lipoprotein (LDL) cholesterol potently reduces cardiovascular risk while concurrently increasing type 2 diabetes risk. Objective The aim this study was to investigate the relationship between LDL concentrations and insulin secretion glucagon levels. Methods A total 3039 individuals without cholesterol-lowering therapy, but with increased for diabetes, underwent routine blood tests a 5-point oral glucose tolerance test (OGTT). Glucagon...
The green fluorescent protein (GFP)‐homologous red (RFP) from Discosoma (drFP583) which emits bright fluorescence peaking at 583 nm is an interesting novel genetic marker. We show here that RFP maturation involves a GFP‐like fluorophore can be stabilized by point mutations selected randomly mutated expression library. By homology modeling, these cluster near the imidazolidinone ring of chromophore. Exciting absorption band in mutant proteins produces both and fluorescence. Upon unfolding...
Ultrafast, intra-oligomer fluorescence resonance energy transfer (FRET) between an immature green-emitting GFP-like chromophore to the mature red-emitting is found in novel red fluorescent protein wt-DsRed (the picture shows steady-state absorption (solid line) and emission (dotted) spectra). Since FRET by its very nature a short range process, it represents highly suitable method probe oligomerization. This work describes preferentially applicable efficient screening of variants with...
Fat accumulation within the pancreatic parenchyma is known to be a risk factor for number of conditions, including cancer and chronic pancreatitis.1 There also growing evidence that fat may contribute pathogenesis diabetes.1, 2 Adipocytes pancreas could impair insulin secretion via secreted factors.1, 3 Some studies reported fatty linked reduced secretion, particularly in persons with prediabetes, while other trials did not detect any such associations.1 Previous findings DiRECT lifestyle...
Even well-treated gestational diabetes mellitus (GDM) might still have impact on long-term health of the mother and her offspring, although this relationship has not yet been conclusively studied. Using in-depth phenotyping we aim to elucidate maternal hyperglycaemia during pregnancy adequate treatment, its both child.
Parasympathetic nervous system innervates peripheral organs including pancreas, hepatic portal system, and gastrointestinal tract. It thereby contributes to the regulation of whole-body glucose metabolism especially in postprandial state when it promotes secretion insulin enhances its action major target organs. We now aimed evaluate effect parasympathetic modulation on human metabolism. used slow deep breathing maneuvers activate tested for effects during an oral tolerance test a...
Abstract The selection of carbohydrates or fat to generate intracellular energy is thought be crucial for long-term metabolic health. While most studies assess fuel after a challenge, the determinants substrate oxidation in fasted state remain largely unexplored. We therefore assessed respiratory quotient by indirect calorimetry as read-out following an overnight fast. This cross-sectional analysis consisted 192 (92 women, 100 men) either lean obese participants. Following fast, (RQ) was...
Ängste und Vorbehalte gegenüber einer indizierten Insulintherapie (psychologische Insulinresistenz=PIR) sind bei Patienten mit Diabetes weit verbreitet. Bisher ist unklar, in welchem Ausmaß multimorbide ältere Diabetiker hiervon betroffen sind. Ziel der Studie eine systematische Erfassung von PIR geriatrischen mellitus Typ 2 (DM) ohne Insulintherapie.
Zusammenfassung Einleitung Präventionsketten sind integrierte kommunale Strategien zur Förderung von Gesundheit und sozialer Teilhabe Kindern, Jugendlichen Familien sowie Vermeidung der Folgen Kinderarmut. Sie als intersektorale Netzwerke in mehreren Kommunen Deutschland etabliert. Der Aufbau Neubaugebieten wurde bislang noch nicht systematisch erforscht. Im Rahmen Prozessevaluation Präventionskette Freiham, die dem sich derzeit im Bau befindlichen gleichnamigen Münchner Stadtteil...
Introduction & Objectives: Research suggests that reduced regional brain volumes in specific areas are important for cognitive functions persons with type 2 diabetes. How this relates to novel diabetes endotypes is unknown. Methods: We therefore investigated MRI-derived from 464 participants of the UK-Biobank, who had up 5 years duration and available clinical data. estimated group membership clusters introduced by Ahlqvist et al. using approach proposed Antonio-Villa relies on BMI, HDL,...
Introduction & Objective: Individuals with type 2 diabetes (T2D) are thought to have a smaller pancreas; however, whether this is cause or consequence of T2D unclear. We investigated the association between pancreas volume and risk was modified by pancreatic fat. Methods: Using magnetic resonance imaging from UK Biobank, 25,389 individuals were classified into four groups based on median values (60 cm3) fat (8%). Odds ratios (ORs) for prevalent estimated using logistic regression....
Das Gehirn wurde lange als insulinunabhängiges Organ angesehen, da Insulin die Glukoseaufnahme in Neurone nicht beeinflusst. Mit dem Nachweis von Insulinrezeptoren im [1] rückte Aufklärung der Wirkung jedoch das Interesse Forschung. Erste Ergebnisse aus Tierexperimenten zeigen eine Verringerung Nahrungsaufnahme sowie des Körpergewichts nach direkter Verabreichung ins [2]. Auch beim Menschen beeinflusst Gehirnaktivität mit metabolischen und kognitiven Auswirkungen auf den Körper, welche...
Die Untersuchung intraindividueller Unterschiede des Stoffwechsels und Diabetesrisikos führte zur Identifizierung von Subgruppen Prädiabetes Diabetes mellitus. Diese unterscheiden sich in ihrem Risiko für Komplikationen ihrer Mortalität deutlich. mit hohem Komplikationsrisiko sind u. a. durch eine spezifische Körperfettverteilung vermehrtem viszeralem Fett gekennzeichnet. Ihr spezifischer Phänotyp ähnelt jenem Personen einer Insulinresistenz im Gehirn. Dies weist auf mögliche...
Introduction & Objective: Postprandial hypoglycemia describes a condition with abnormally low glucose within few hours after carbohydrate-rich meals. Underlying mechanisms are still unclear, hypotheses including an unusually rapid increase in blood glucose, excessive insulin release, or prolonged presence of elevated insulin. We now analyzed these possibilities large sample oral tolerance tests (oGTT). Methods: Patients without diabetes underwent (180 min) 75 g oGTT as part clinical work...
Abstract Context Central insulin has been shown to regulate eating behavior and cognitive processes in a sex-specific manner. Besides memory, the hippocampus is pivotal control of appetite. Objective This work aimed investigate how interacts with hippocampal food-cue response evaluate potential role sex hormones. Methods Using functional magnetic resonance imaging, we evaluated task-based connectivity (FC) during presentation 60 participants (age: 21-69 years; 30 women) after intranasal or...