A5101584177- Pancreatic and Hepatic Oncology Research
- Pancreatic function and diabetes
- Pancreatitis Pathology and Treatment
- Laser-Matter Interactions and Applications
- Diabetes and associated disorders
- Magnetic properties of thin films
- NF-κB Signaling Pathways
- Spectroscopy and Quantum Chemical Studies
- Renal and related cancers
- Advanced Chemical Physics Studies
- Advanced Electron Microscopy Techniques and Applications
- Peptidase Inhibition and Analysis
- TGF-β signaling in diseases
- Immunotherapy and Immune Responses
- Diabetes Management and Research
- Esophageal and GI Pathology
- Immune Cell Function and Interaction
- Congenital heart defects research
- Endoplasmic Reticulum Stress and Disease
- Pluripotent Stem Cells Research
- Helicobacter pylori-related gastroenterology studies
- Quantum and electron transport phenomena
- Advanced Condensed Matter Physics
- Advanced X-ray Imaging Techniques
- Cancer Genomics and Diagnostics
Technical University of Munich
2012-2024
University Hospital Ulm
2007-2024
Universität Ulm
2010-2023
The George Institute for Global Health
2023
UNSW Sydney
2023
Max Planck Institute for Plasma Physics
2022
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2021
Institut für Technische und Angewandte Physik (Germany)
2015
Max Planck Computing and Data Facility
2015
Universitätsmedizin Greifswald
2015
Infection-related diabetes can arise as a result of virus-associated β-cell destruction. Clinical data suggest that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing disease 2019 (COVID-19), impairs glucose homoeostasis, but experimental evidence SARS-CoV-2 infect pancreatic tissue has been lacking. In present study, we show infects cells human exocrine and endocrine pancreas ex vivo in vivo. We demonstrate β-cells express viral entry proteins, replicates cultured...
Mouse embryonic stem (ES) cells differentiate into of all three primary germ layers including endodermal that produce insulin in vitro . We show constitutive expression Pax4 (Pax4 + ), and to a lesser extent Pdx1 (Pdx1 affects the differentiation ES significantly promote development insulin-producing cells. In overexpressing R1 cells, isl-1, ngn3, insulin, islet amyloid polypeptide, glucose transporter 2 (Glut-2) mRNA levels increase significantly. The number nestin-expressing (nestin+) also...
We report a long-wavelength helimagnetic superstructure in bulk samples of the ferrimagnetic insulator Cu2OSeO3. The magnetic phase diagram associated with modulation inferred from small angle neutron scattering and magnetisation measurements includes skyrmion lattice is strongly reminiscent MnSi, FeGe Fe1-xCoxSi, i.e., binary isostructural siblings Cu2OSeO3 that order helimagnetically. temperature dependence specific heat characteristic nearly critical spin fluctuations at transition. This...
A scannable laser beam is used to generate local thermal gradients in metallic (Co2FeAl) or insulating (Y3Fe5O12) ferromagnetic thin films. We study the resulting charge and spin currents that arise due anomalous Nernst effect (ANE) Seebeck (SSE), respectively. In ANE experiments, we detect voltage Co2FeAl film plane as a function of spot position external magnetic field magnitude orientation. The SSE detected similar fashion by exploiting inverse Hall Pt layer deposited on top Y3Fe5O12. Our...
Objective The generation of acinar and ductal cells from human pluripotent stem (PSCs) is a poorly studied process, although various diseases arise this compartment. Design We designed straightforward approach to direct PSCs towards pancreatic organoids resembling progeny. Results Extensive phenotyping the not only shows appropriate marker profile but also ultrastructural, global gene expression functional hallmarks pancreas in dish. Upon orthotopic transplantation into immunodeficient mice,...
This study describes a tumor progression model for ductal pancreatic cancer in mice overexpressing TGF-α. Activation of Ras and Erk causes induction cyclin D1-Cdk4 without increase E or PCNA lesions. Thus, TGF-α is able to promote throughout G 1 , but not S phase. Crossbreeding with p53 null accelerates development transgenic dramatically. In tumors developing these mice, biallelic deletion Ink4a/Arf LOH the Smad4 locus found suggesting that loci addition are involved antitumor activities....
Activation of matrix metalloproteinase-2 (MMP-2) by the membrane-type metalloproteinases (MT-MMPs) has been associated with tumor progression. In present study, we examined role MMP-2 and its activators MT1-MMP, MT2-MMP MT3-MMP in pancreatic cell invasion development desmoplastic reaction characteristic cancer tissues. Northern blot analyses revealed that transcript levels MT1-MMP MT2-MMP, but not MT3-MMP, were enhanced tissues (n = 18) compared both chronic pancreatitis 9) healthy pancreas...
We report detailed low-temperature magnetotransport and magnetization measurements in MnSi under pressures up to $\ensuremath{\sim}12\phantom{\rule{0.28em}{0ex}}\mathrm{kbar}$. Tracking the role of sample quality, pressure transmitter, field temperature history allows us link emergence a giant topological Hall resistivity $\ensuremath{\sim}50\phantom{\rule{0.28em}{0ex}}\mathrm{n}\ensuremath{\Omega}\phantom{\rule{0.16em}{0ex}}\mathrm{cm}$ skyrmion lattice phase at ambient pressure. show that...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is associated with accumulation of particular oncogenic mutations and recent genetic sequencing studies have identified ataxia telangiectasia-mutated (ATM) in PDAC cohorts. Here we report that conditional deletion ATM a mouse model induces greater number proliferative precursor lesions coupled pronounced fibrotic reaction. ATM-targeted mice display altered TGFβ-superfamily signalling enhanced epithelial-to-mesenchymal transition (EMT)...
Pancreatic ductal adenocarcinomas (PDAC) harbor recurrent functional mutations of the master DNA damage response kinase ATM, which has been shown to accelerate tumorigenesis and epithelial-mesenchymal transition. To study how ATM deficiency affects genome integrity in this setting, we evaluated molecular effects conditional Atm deletion a mouse model PDAC. was associated with increased mitotic defects, genomic rearrangements, deregulated checkpoints, reminiscent human We hypothesized that...
Abstract The transcription factor NF‐κB/Rel was found to be constitutively activated in human pancreatic cancer. RelA is present the nucleus primary cancer samples as well cell lines. NF‐κB/Rel–binding activity consists of NF‐κB1(p50) and RelA(p65). Constitutive correlates with IκB kinase (IKK) can blocked by dominant negative mutants IKKβ a lesser extent IKKα. transactivation potential RelA(p65) inhibited mutant Ras, PI3 inhibitor LY294002, or Akt kinase. Transfection epidermal growth...
The Dzyaloshinskii-Moriya interaction in the cubic chiral magnet MnSi stabilizes a magnetic helix - periodic one-dimensional modulation of magnetization. orientation this is determined by weak magnetocrystalline anisotropies, but it can be reoriented applying field. Here, authors have studied reorientation process means small-angle neutron scattering and susceptibility measurements. Their results are excellent agreement with predictions an effective mean-field theory taking into account...
(ATM) is the most frequently mutated DNA damage response gene, involved in homologous recombination (HR), pancreatic ductal adenocarcinoma (PDAC).
The pancreas morphology of transgenic mice that overexpress transforming growth factor-β1 (TGF-β1) in the resembles partially morphological features chronic pancreatitis, such as progressive accumulation extracellular matrix (ECM). Using this mouse model, we characterized composition pancreatic fibrosis and involved fibrogenic mediators. On day 14 after birth, fibrotic tissue was mainly composed collagen type I III. At time, mRNA levels TGF-β1 were increased. 70, ECM expanded by increased...
<h3>Background</h3> Tumour angiogenesis is crucially dependent on the communication between tumour and associated endothelium. Protein kinase D (PKD) isoenzymes mediate vascular endothelial growth factor-A (VEGF-A) induced cell proliferation migration are also highly expressed in various tumours. <h3>Aim</h3> To examine role of PKDs for selectively pancreatic gastric tumours tumour-associated endothelium vitro vivo. <h3>Methods</h3> PKD2 expression human was determined by...