A5070918373- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Genomics and Rare Diseases
- Pancreatic function and diabetes
- Pharmacological Effects of Medicinal Plants
- Renal and related cancers
- Colorectal Cancer Treatments and Studies
- Biomedical Text Mining and Ontologies
- RNA Interference and Gene Delivery
- 3D Printing in Biomedical Research
- Lipid Membrane Structure and Behavior
- Acute Myeloid Leukemia Research
- PI3K/AKT/mTOR signaling in cancer
- Electrospun Nanofibers in Biomedical Applications
- Congenital Heart Disease Studies
- Surfactants and Colloidal Systems
- Nanoparticle-Based Drug Delivery
- RNA modifications and cancer
- Catalysis for Biomass Conversion
- Radiopharmaceutical Chemistry and Applications
- Nanoplatforms for cancer theranostics
- Fluorine in Organic Chemistry
- Pluripotent Stem Cells Research
- Wikis in Education and Collaboration
- biodegradable polymer synthesis and properties
Leipzig University
2013-2023
Heinrich Heine University Düsseldorf
2022-2023
University Hospital Ulm
2021
La Roche College
2020-2021
Pharmaceutical Biotechnology (Czechia)
2021
King's College London
2018
Martin Luther University Halle-Wittenberg
2018
University of York
2017
Universität Ulm
2012
South Valley University
2012
A family of monomers, including 2,5-hexandiol, 2,7-octandiol, 2,5-furandicarboxylic acid (FDCA), terephthalic (TA), and branched-chain adipic pimelic derivatives, all find a common derivation in the biomass-derived platform molecule 5-(chloromethyl)furfural (CMF). The diol previously little known to polymer chemistry, have been combined with FDCA TA derivatives produce range novel polyesters. It is shown that use secondary diols leads polymers higher glass transition temperatures...
RNA interference opened new approaches for disease treatment but safe and efficient cell delivery remains a bottleneck. Extracellular vesicles (EVs) are known to naturally shuttle RNA. Due their potent internalization low-cost scalability, milk-derived EVs in particular considered promising systems. However, low drug loading currently impedes use. Here, innovative exogenous strategies small interfering (siRNA) explored systematically compared regarding encapsulation efficiency, capacity,...
The mammalian target of rapamycin (mTOR) is a key regulator cell growth and its uncontrolled activation hallmark cancer. Moreover, mTOR has been implicated in the resistance cancer cells to many anticancer drugs, rendering this pathway promising pharmacotherapeutic target. Here we explored capability semisynthetic compound intercept signaling. We synthesized chemically characterized novel, triterpenoid derivative, 3-cinnamoyl-11-keto-<i>β</i>-boswellic acid (C-K<i>β</i>BA). Its...
Patient-derived induced pluripotent stem cells (iPSCs) provide a unique platform to study hereditary disorders and predisposition syndromes by resembling germline mutations of affected individuals their potential differentiate into nearly every cell type the human body. We employed plucked hair from two siblings with family history cancer carrying pathogenic CDKN2A variant, P16-p.G101W/P14-p.R115L, generate patient-specific iPSCs in cancer-prone ancestry for downstream analytics. The...
Convection-enhanced delivery (CED) has been introduced as a concept in cancer treatment to generate high local concentrations of anticancer therapeutics and overcome the limited diffusional distribution, e.g., brain. RNA interference provides interesting therapeutic options fight cells but requires nanoparticulate (NP) carriers with size below 100 nm well low zeta potential for CED application. In this study, we investigated calcium phosphate NPs (CaP-NPs) siRNA Since CaP-NPs tend aggregate,...
Injectable gelatine-based hydrogels are valuable tools for drug and cell delivery due to their extracellular matrix-like properties that can be adjusted by the degree of cross-linking. We have established anhydride-containing oligomers cross-linking gelatine via anhydride-amine-conjugation. So far, this conversion required conditions not compatible with encapsulation or in vivo injection. In order overcome limitation, we developed an array quarter-oligomers varying comonomer composition...
This study evaluated the accuracy of NAVIFY Mutation Profiler, a cloud-based CE-IVD software that aids in interpreting clinically relevant variants detected somatic oncology next-generation sequencing tests. tool reports tiered classifications based on different levels clinical evidence from highly curated, regularly updated database derived medical guidelines, drug approvals, and peer-reviewed literature. A retrospective analysis was performed results 37 lung cancer cases treated with...
This study describes the synthesis, radiofluorination and purification of an anionic amphiphilic teroligomer developed as a stabilizer for siRNA-loaded calcium phosphate nanoparticles (CaP-NPs). As stabilizing amphiphile accumulates on nanoparticle surfaces, fluorine-18-labeled polymer should enable to track distribution CaP-NPs in brain tumors by positron emission tomography after application convection-enhanced delivery. At first, unmodified was synthesized with number average molecular...
Abstract 3‐O‐Acetyl‐11‐keto‐β‐boswelliasäure wurde aus pulverisiertem Weihrauchgranulat extrahiert und durch HPLC gereinigt. Alle analytischen Spektren sind vollständig entweder im Hauptteil oder in der supporting information wiedergegeben. Die NMR‐ sowie die Massenspektren werden eingehend interpretiert mit theoretischen Berechnungen 13 C‐chemischen Verschiebungen verglichen. Das Projekt stellt eine Fortsetzung des Buches “Classics Spectroscopy” von S. Berger D. Sicker (Wiley‐VCH 2009) dar.
Abstract INTRODUCTION: Assessing the actionability of variants identified in next-generation sequencing (NGS) solid tumors is challenging. Recommendations from AMP/ASCO/CAP/ACMG (Li et al. JMD 2017) provide guidelines for prioritizing based on clinical significance and actionability. Sirohi (JMD 2020) reported interrater agreement with AMP by distributing 51 tumor NGS to 20 participants at 10 US academic molecular diagnostics laboratories. Initial independent assessment amongst experts was...
e18086 Background: The increasing adoption of Next Generation Sequencing (NGS) in molecular profiling cancer presents a growing need for streamlined interpretation NGS results clinical labs. This can be achieved through bioinformatics tools equipped with highly-curated database on clinically important variants. Methods: We performed an initial assessment result tool called NAVIFY Mutation Profiler (NMP), which enabled us to process Variant Call Format (VCF) file and generate report consensus...
e14072 Background: Evolving medical guidelines and complex multi-variant data from next-generation sequencing (NGS) testing of cancer samples make routine clinical interpretation somatic variants challenging. We assessed the ability NAVIFY(R) Mutation Profiler*, a CE-IVD variant tool, to yield accurate time- geography-specific content on 2511 The Cancer Genome Atlas (TCGA) across six solid tumor types. Methods: Whole exomes lung adenocarcinoma (n = 469), squamous cell carcinoma 325), colon...
Technological advances have allowed for expanded applications of prenatal cell-free DNA (cfDNA) analysis to screen some subchromosomal copy number variants, but adoption into clinical care requires robust performance data demonstrate that testing can be implemented without significantly increasing false-positive rates. This study evaluates the a targeted cfDNA test (Harmony® test) 22q11.2 deletions in large cohort. Samples were obtained through prospective, multicentre collection maternal...