A5080155645- Pancreatic function and diabetes
- Pancreatitis Pathology and Treatment
- Ion Transport and Channel Regulation
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Cystic Fibrosis Research Advances
- Apelin-related biomedical research
- Electrochemical sensors and biosensors
- Diet, Metabolism, and Disease
- Phagocytosis and Immune Regulation
- Epigenetics and DNA Methylation
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- 3D Printing in Biomedical Research
- Ion Channels and Receptors
- Erythrocyte Function and Pathophysiology
- Genomics and Chromatin Dynamics
- Renal and related cancers
- Enzyme Catalysis and Immobilization
- Synthesis and properties of polymers
- Plasma and Flow Control in Aerodynamics
- DNA Repair Mechanisms
- Cellular Mechanics and Interactions
- Magnesium in Health and Disease
- Galectins and Cancer Biology
- Quantum Dots Synthesis And Properties
University of Szeged
1992-2024
MTA-SZTE Research Group on Artificial Intelligence
2015-2018
Montavid Thermodynamic Research Group
2017
Regardless of its aetiology, sustained intracellular Ca2+ overload is a well-known hallmark acute pancreatitis (AP). Toxic elevation induces pancreatic ductal cell damage characterized by impaired ion and fluid secretion - essential to wash out the protein-rich secreted acinar cells while maintaining alkaline intra-ductal pH under physiological conditions mitochondrial dysfunction. While prevention injury decreases severity AP, no specific drug target has yet been identified in cells....
Patients with recurrent acute pancreatitis (RAP) are at significant risk of developing early chronic (CP), which progresses into irreversible, end-stage CP severe symptoms. There is no specific therapy in RAP or that may hinder disease progression. The pathogenesis complex and involves interactions among multiple cell types, including pancreatic acinar, ductal, stellate cells (PSC). Therefore, it pivotal to identify common pathogenic pathways these could be targeted pharmacologically....
Key points Acute biliary pancreatitis is a significant clinical challenge as currently no specific pharmaceutical treatment exists. Intracellular Ca 2+ overload, increased reactive oxygen species (ROS) production, mitochondrial damage and intra‐acinar digestive enzyme activation caused by bile acids are hallmarks of acute pancreatitis. Transient receptor potential melastatin 2 (TRPM2) non‐selective cation channel that has recently emerged an important contributor to oxidative‐stress‐induced...
Smoking is recognised as an independent risk factor in the development of chronic pancreatitis (CP). Cystic fibrosis transmembrane conductance regulator (CFTR) function and ductal fluid bicarbonate secretion are also known to be impaired CP, so it crucial understand relationships between smoking, pancreatic CP.
Application of antioxidant enzymes in medical or industrial processes is limited due to their high sensitivity environmental conditions. Incorporation such nanostructures provides a promising route obtain highly efficient and robust biocatalytic system scavenge reactive oxygen species (ROS). Here, this question was addressed by confinement superoxide dismutase (SOD), horseradish peroxidase (HRP), catalase (CAT) into containing polyelectrolyte building blocks (alginate (Alg) trimethyl...
Epithelial ion and fluid secretion determine the physiological functions of a broad range organs, such as lung, liver, or pancreas. The molecular mechanism pancreatic is challenging to investigate due limited access functional human ductal epithelia. Patient-derived organoids may overcome these limitations, however direct accessibility apical membrane not solved. In addition, vectorial transport ions intraluminal pressure in elevated, which hinder study processes. To these, we developed an...
To efficiently harness the possible synergies, stemming from combination of organic conducting polymers and inorganic semiconductors, sophisticated assembling methods are required to control composition morphology at nanoscale. In this proof-of-concept study, we demonstrate in situ photocatalytic deposition CdS nanoparticles on poly(3-hexylthiophene) (P3HT) nanofibers, exploiting semiconducting nature polymer. The formation hybrid assembly was monitored by UV–vis Raman spectroscopy,...
In this paper, we present the first report on an organic conducting polymer film, which alone exhibits both superhydrophobicity and visible light photoactivity. The microstructure of poly(3-hexylthiophene) was optimized using controlled precipitation until superhydrophobic behavior achieved. Photocatalytic tests employing irradiation proved that degrades ethanol test molecule.
Abstract Background and Aims Crohn’s disease [CD] ulcerative colitis [UC] require lifelong treatment patient monitoring. Current biomarkers have several limitations; therefore, there is an unmet need to identify novel in inflammatory bowel [IBD]. Previously, the role of plasminogen activator inhibitor 1 [PAI-1] was established pathogenesis IBD suggested as a potential biomarker. Therefore, we aimed comprehensively analyse selectivity PAI-1 IBD, its correlation with activity, predict...
A hybrid material (SL-PPN-HEP-HRP) of dual enzyme function was prepared by co-immobilization papain (PPN) and horseradish peroxidase (HRP) on sulphate latex (SL) microspheres using heparin (HEP) polyelectrolyte as a building block in the sequential adsorption method. The doses PPN, HEP HRP were optimized each step preparation process to achieve high functional colloidal stability. enzymes strongly adsorbed oppositely charged surfaces via electrostatic forces, leakage not observed from...
The immobilization of catalase (CAT), a crucial oxidoreductase enzyme involved in quenching reactive oxygen species, on colloids and nanoparticles presents promising strategy to improve dispersion storage stability while maintaining its activity. Here, the CAT onto polymeric (positively (AL) or negatively (SL) charged) was implemented directly via surface functionalization with water-soluble chitosan derivatives (glycol (GC) methyl glycol (MGC)). interfacial properties were optimized obtain...
Abstract Since their discovery, 3D cell cultures have emerged as powerful tools across various basic, translational research, and industrial discovery projects. One such application is in the physiological pathophysiological modeling of pancreatic exocrine functions, which addresses critical clinical challenges, including acute chronic pancreatitis. While several methods now exist for generating epithelial organoids (derived from induced pluripotent, embryonic, or adult stem cells), advent...
Thiopurine-induced acute pancreatitis (TIP) is one of the most common adverse events among inflammatory bowel disease patients treated with azathioprine (AZA), representing a significant clinical burden. Previous studies focused on immune-mediated processes, however, exact pathomechanism TIP essentially unclear.To model in vivo, we triggered cerulein-induced experimental mice receiving daily oral dose 1.5 mg/kg AZA. Also, freshly isolated mouse pancreatic cells were exposed to AZA ex and...
ABSTRACT Exocrine pancreatic damage is a common complication of cystic fibrosis (CF), which can significantly debilitate the quality life and expectancy CF patients. The transmembrane conductance regulator (CFTR) has major role in ductal ion secretion, however, it presumably an influence on intracellular signaling as well. Here we describe multiple model systems, including iPSC-derived human organoids from patients, that activity PMCA4 impaired by decreased expression CFTR cells. regulation...
Abstract Background and aims. Alcoholic pancreatitis hepatitis are frequent, potentially lethal diseases with limited treatment options. Our previous study reported that the expression of CFTR Cl - channel is impaired by ethanol in pancreatic ductal cells leading to more severe alcohol-induced pancreatitis. In addition determining epithelial ion secretion, has multiple interactions other proteins, which may influence intracellular Ca 2+ signaling. Thus, we aimed investigate impact...