A5057257315- Pancreatitis Pathology and Treatment
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Esophageal Cancer Research and Treatment
- Gastroesophageal reflux and treatments
- Neuroendocrine Tumor Research Advances
- Lung Cancer Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Eosinophilic Esophagitis
- Monoclonal and Polyclonal Antibodies Research
- Esophageal and GI Pathology
- Gastrointestinal Tumor Research and Treatment
- Lung Cancer Treatments and Mutations
- Inflammatory Bowel Disease
- Genetic factors in colorectal cancer
- HER2/EGFR in Cancer Research
- IgG4-Related and Inflammatory Diseases
- Toxin Mechanisms and Immunotoxins
- Colorectal Cancer Surgical Treatments
- Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Liver Disease Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Drug Transport and Resistance Mechanisms
University of Szeged
2015-2024
King's College London
2016
Centro Cardiologico Monzino
2016
Institute of Experimental Cardiology
2016
Imperial College London
2016
University of Florence
2016
Health First
2012
Hepatocellular carcinoma (HCC) is rare in young children. We attempted to see if immunohistochemical and mutational-analysis studies could demonstrate that deficiency of the canalicular bile acid transporter salt export pump (BSEP) mutation ABCB11 , encoding BSEP, underlay progressive familial intrahepatic cholestasis (PFIC)—or “neonatal hepatitis” suggesting PFIC—that was associated with HCC studied 11 cases pediatric setting PFIC or PFIC. Archival liver were retrieved immunostained for...
Several conditions associated with reduced gastric acid secretion confer an altered risk of developing a malignancy. Helicobacter pylori-induced atrophic gastritis predisposes to adenocarcinoma, autoimmune is precursor type I neuroendocrine tumours, whereas proton pump inhibitor (PPI) use does not affect stomach cancer risk. We hypothesised that each these was specific alterations in the microbiota and this influenced subsequent tumour 95 patients (in groups representing normal stomach, PPI...
Oral squamous cell carcinoma (OSCC) is a serious health issue worldwide that accounts for 2% to 4% of all cancer cases. Previous studies have revealed higher yeast carriage and diversity in oral patients than healthy individuals.
The in-hospital survival of patients suffering from acute pancreatitis (AP) is 95% to 98%. However, there growing evidence that discharged after AP may be at risk serious morbidity and mortality. Here, we aimed investigate the risk, causes, predictors most severe consequence post-AP period: mortality.A total 2613 well-characterized 25 centers were included followed by Hungarian Pancreatic Study Group between 2012 2021. A general a hospital-based population was used as control group.After an...
In most HCO(3)(-)-secreting epithelial tissues, SLC26 Cl(-)/HCO(3)(-) transporters work in concert with the cystic fibrosis transmembrane conductance regulator (CFTR) to regulate magnitude and composition of secreted fluid, a process that is vital for normal tissue function. By contrast, CFTR regarded as only exit pathway HCO(3)(-) airways. Here we show anion exchange makes major contribution transcellular transport airway serous cells. Real-time measurement intracellular pH from polarized...
Despite the large efforts to prepare super paramagnetic iron oxide nanoparticles (MNPs) for biomedical applications, number of FDA or EMA approved formulations is few. It not known commonly that in many instances have already been withdrawn discontinued by producers; at present, hardly any are produced and marketed. Literature survey reveals there a lack accepted physicochemical practice designing qualifying before they enter vitro vivo biological testing. Such standard procedure would...
Although accumulating evidence suggests that the crosstalk between malignant cells and cancer-associated fibroblasts (CAFs) actively contributes to tumour growth metastatic dissemination, therapeutic strategies targeting stroma are still not common in clinical practice. Metal-based nanomaterials have been shown exert excellent cytotoxic anti-cancerous activities, however, their effects on reactive never investigated details. Thus, using feasible vitro vivo systems model microenvironment, we...
To determine the expression of endogenous adhesion/growth-regulatory lectins and their binding sites using labeled tissue as well profile hyaluronic acid an approach to define new prognostic markers.Sections paraffin-embedded histological material 481 lungs from lung tumor patients following radical excision processed by a routine immunohistochemical method (avidin-biotin labeling, DAB chromogen). Specific antibodies against galectins-1 -3 heparin-binding lectin were tested. Staining...
Only limited data are available regarding the diagnostic accuracy of fecal matrix metalloprotease-9 [MMP-9] for inflammatory bowel disease [IBD]. The aims our study were to assess MMP-9 in patients with active Crohn's [CD], ulcerative colitis [UC], and pouchitis, compare calprotectin [CP] IBD. Stool blood samples collected 50 CD, 54 UC, 34 ileal pouch-anal anastomosis before control endoscopies performed. Biopsies taken histologic purposes. activities pouchitis defined use clinical,...
Stromal cells, including cancer-associated myofibroblasts (CAMs), are recognised to be determinants of cancer progression, but the mechanisms remain uncertain. The chemokine-like protein, chemerin, is upregulated in oesophageal squamous (OSC) CAMs compared with adjacent tissue (ATMs). In this study, we hypothesised that chemerin stimulates OSC cell invasion. Expression receptor, ChemR23, was examined by immunohistochemistry. invasion cells studied using Boyden chambers and organotypic...
Abstract Chronic pancreatitis (CP) is an end-stage disease with no specific therapy; therefore, early diagnosis of crucial importance. In this study, data from 1315 and 318 patients were analysed acute (AP) CP registries, respectively. The population the AP registry was divided into (n = 983), recurrent (RAP, n 270) 62) groups. prevalence in combination AP, RAP2, RAP3, RAP4 RAP5 + 0%, 1%, 16%, 50% 47%, respectively, suggesting that three or more episodes a strong risk factor for CP....
Nitric oxide (NO) has been implicated in the regulation of pancreatic circulation, promotion capillary integrity, and inhibition leukocyte adhesion.To investigate rates changes constitutive NO synthase (cNOS) inducible NOS (iNOS) activities role vascular permeability during development L-arginine (Arg)-induced acute pancreatitis.Acute pancreatitis was induced male Wistar rats by injecting 250 mg/100 g body weight Arg i.p. twice at an interval 1 hour, as a 20% solution 0.15 NaCl (group I)....
Intracellular pathogen receptor NOD1 is involved in the epithelial cell sensing Helicobacter pylori, which results a considerable interleukin (IL)-8 production. The aim of this study was to evaluate relationship between and IL-8 genetic polymorphisms development H. pylori-induced gastritis duodenal ulcer (DU), as compared with TLR4 polymorphisms.Eighty-five patients DU 135 were enrolled study. Seventy-five serologically pylori-positive subjects without gastric or symptoms served controls....
<h3>Background</h3> Acute pancreatitis is among the few inflammatory diseases for which no specific pharmacological treatment available. It has previously been shown that bile acids alter pancreatic ductal secretion and these effects are probably involved in pathogenesis of bile-induced pancreatitis. <h3>Objective</h3> To understand mechanism responsible hypersecretion and, particular, to identify molecular target native duct epithelial cells (PDECs). <h3>Methods</h3> Patch clamp recordings...
Stromal cells such as myofibroblasts influence tumor progression. The mechanisms are unclear but may involve effects on both and recruitment of bone marrow-derived mesenchymal stromal (MSCs) which then colonize tumors. Using iTRAQ LC-MS/MS we identified the adipokine, chemerin, overexpressed in esophageal squamous cancer associated (CAMs) compared with adjacent tissue (ATMs). chemerin receptor, ChemR23, is expressed by MSCs. Conditioned media (CM) from CAMs significantly increased MSC cell...
Background: Several epidemiological and laboratory studies have evidenced the fact that atmospheric particulate matter (PM) increases risk of respiratory morbidity.It is well known smallest fraction PM (PM1particulate having a diameter below 1 μm) penetrates deepest into airways.The ratio different size fractions in highly variable, but industrial areas PM1 can be significant.Despite these facts, health effects been poorly investigated air quality standards are based on PM10 PM2.5 (PM...