A5023626251- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Cholesterol and Lipid Metabolism
- Adipose Tissue and Metabolism
- Cardiac Imaging and Diagnostics
- MicroRNA in disease regulation
- Peptidase Inhibition and Analysis
- Cardiac Fibrosis and Remodeling
- Neuropeptides and Animal Physiology
- Signaling Pathways in Disease
- Antioxidant Activity and Oxidative Stress
- Cardiovascular and exercise physiology
- Lipoproteins and Cardiovascular Health
- Diabetes Treatment and Management
- Chemotherapy-induced cardiotoxicity and mitigation
- Hypothalamic control of reproductive hormones
- Fatty Acid Research and Health
- Diet, Metabolism, and Disease
- Vitamin C and Antioxidants Research
- Protease and Inhibitor Mechanisms
- Nitric Oxide and Endothelin Effects
- Coenzyme Q10 studies and effects
- Diet and metabolism studies
- Dialysis and Renal Disease Management
- Pancreatic function and diabetes
University of Szeged
2015-2025
University of Pecs
2022
Abstract Background Metabolic syndrome (coexisting visceral obesity, dyslipidemia, hyperglycemia, and hypertension) is a prominent risk factor for cardiovascular morbidity mortality, however, its effect on cardiac gene expression pattern unclear. Therefore, we examined the possible alterations in male Zucker Diabetic Fatty (ZDF) rats, model of metabolic syndrome. Methods Fasting blood glucose, serum insulin, cholesterol triglyceride levels were measured at 6, 16, 25 wk age ZDF lean control...
Dipeptidyl peptidase-4 (DPP-4) inhibitors are a class of oral anti-diabetic drugs, implicated in pleiotropic secondary cardioprotective effects. The aim the study was to unveil unknown and possible targets that can be exerted by sitagliptin (Sitg) against ischemia-reperfusion (I/R) injury. Male wistar rats received 2 weeks' Sitg treatment different doses (25, 50, 100, 150 mg/kg/day), or saline as Control. Hearts were then isolated subjected two I/R injury protocols: 10 min perfusion, 45...
Abstract Chronic kidney disease (CKD) is a public health problem that increases the risk of cardiovascular morbidity and mortality. Heart failure with preserved ejection fraction (HFpEF) characterized by left ventricular hypertrophy (LVH) diastolic dysfunction common complication CKD. MicroRNA-212 (miR-212) has been demonstrated previously to be crucial regulator pathologic LVH in pressure-overload-induced heart via regulating forkhead box O3 (FOXO3)/calcineurin/nuclear factor activated...
Prediabetes is a condition affecting more than 35% of the population. In some forms, excessive carbohydrate intake (primarily refined sugar) plays prominent role. symptomless, mostly unrecognized disease which increases cardiovascular risk. our work, we examined effect fructose-enriched diet on cardiac function and lipidome as well proteome muscle. Male Wistar rats were divided into two groups. The control group received normal while fructose-fed 60% fructose-supplemented chow for 24 weeks....
Uremic cardiomyopathy, characterized by diastolic dysfunction, left ventricular hypertrophy (LVH), and fibrosis, is a common cardiovascular complication of chronic kidney disease (CKD). Men are at higher risk for renal diseases, compared to age-matched, pre-menopausal women. We aimed investigate the influence sex on severity uremic cardiomyopathy through characterization functional molecular indices myocardial remodeling in rat model. CKD was induced 5/6 nephrectomy 9-week-old male female...
Background: A deleterious, late-onset side effect of thoracic radiotherapy is the development radiation-induced heart disease (RIHD). It covers a spectrum cardiac pathology including also failure with preserved ejection fraction (HFpEF) characterized by left ventricular hypertrophy (LVH) and diastolic dysfunction. MicroRNA-212 (miR-212) crucial regulator pathologic LVH via FOXO3-mediated pathways in pressure-overload-induced failure. We aimed to investigate whether miR-212 its selected...
Introduction: The public health threat of substandard and falsified medicines has been well known in the last two decades, several studies focusing on identification products affected preventing consumption have published. However, number these reaching patients causing consequences adverse drug reactions is not a well-researched area. Objectives: Our aim was to identify describe characteristics cases that are related potentially originating from counterfeit medication using publicly...
Lipid accumulation in the liver and pancreas is primarily caused by combined hyperlipidemia. However, effect of isolated hypercholesterolemia without hypertriglyceridemia not fully described. Therefore, our aim was to investigate whether alone leads alterations both hepatic pancreatic lipid panel histology rats.Male Wistar rats were fed with 2% cholesterol +0.25% cholate-supplemented diet or standard chow for 12 weeks. Blood collected at weeks 0, 4, 8 measure serum triglyceride levels. At...
There is a spectacular rise in the global prevalence of type 2 diabetes mellitus (T2DM) due to worldwide obesity epidemic. However, significant proportion T2DM patients are non-obese and they also have an increased risk cardiovascular diseases. As Goto-Kakizaki (GK) rat well-known model T2DM, goal this study was investigate effect on cardiac alterations transcriptome GK rats. Fasting blood glucose, serum insulin cholesterol levels were measured at 7, 11, 15 weeks age male control Oral...
Inappropriate nutrition and a sedentary lifestyle can lead to obesity, one of the most common risk factors for several chronic diseases. Although regular physical exercise is an efficient approach improve cardiometabolic health, exact cellular processes are still not fully understood. We aimed analyze morphological, gene expression, lipidomic patterns in liver adipose tissues response exercise. Healthy (wild type on normal diet) hyperlipidemic, high-fat diet-fed (HFD-fed) apolipoprotein...
Chronic kidney disease is a global health problem affecting 10% to 12% of the population. Uremic cardiomyopathy often characterized by left ventricular hypertrophy, fibrosis, and diastolic dysfunction. Dysregulation neuregulin-1β signaling in heart known contributor failure. The systemically administered recombinant human for 10 days our 5/6 nephrectomy-induced model chronic alleviated progression uremic dysfunction type 4 cardiorenal syndrome. currently presented positive preclinical data...
Red palm oil (RPO) and rooibos have been shown to exhibit cardioprotective properties. RPO is rich in essential fatty acids fat soluble antioxidants while contains polyphenolic compounds with a unique composition of flavonoids. They exert their biological effects different cellular compartments. Therefore the combination these two natural food has potential enhance spectrum available dietary compartments, which could result an enhanced protection against certain pathological conditions such...
Uremic cardiomyopathy is characterized by diastolic dysfunction (DD), left ventricular hypertrophy (LVH), and fibrosis. Angiotensin-II plays a major role in the development of uremic via nitro-oxidative inflammatory mechanisms. In heart failure, beta-3 adrenergic receptor (β3-AR) up-regulated coupled to endothelial nitric oxide synthase (eNOS)-mediated pathways, exerting antiremodeling effects. We aimed compare effects angiotensin-II blocker losartan β3-AR agonist mirabegron cardiomyopathy....
Abstract Background Uremic cardiomyopathy is a common cardiovascular complication of chronic kidney disease (CKD) characterized by left ventricular hypertrophy (LVH) and fibrosis enhancing the susceptibility heart to acute myocardial infarction. In early stages CKD, approximately 60% patients are women. We aimed investigate influence sex on severity uremic infarct size-limiting effect ischemic preconditioning (IPRE) in experimental CKD. Methods CKD was induced 5/6 nephrectomy 9-week-old male...
Abstract Background and Aims The effect of red palm oil (RPO) supplementation on infarct size after ischaemia/reperfusion in a cholesterol enriched diet-induced hyperlipidemic animal model has not been reported. Previous studies reported results the RPO normal diet, whilst evidence protection linked to improved functional recovery, prosurvival kinase, anti-apoptosis NO-cGMP. Therefore, we aimed investigate effects dietary cholesterol-enriched rat involvement matrix metalloproteinase 2 (MMP2)...
Diabetic patients have an increased risk of developing cardiovascular diseases, which are the leading cause death in developed countries. Although multivitamin products widely used as dietary supplements, effects these not been investigated diabetic heart yet. Therefore, here we if a preparation different minerals, vitamins, and trace elements (MVT) affects cardiac gene expression pattern experimental diabetes. Two-day old male Wistar rats were injected with streptozotocin (i.p. 100 mg/kg)...
Radiation-induced heart disease (RIHD) is a potential late side-effect of thoracic radiotherapy resulting in left ventricular hypertrophy (LVH) and fibrosis due to complex pathomechanism leading failure. Angiotensin-II receptor blockers (ARBs), including losartan, are frequently used control failure various etiologies. Preclinical evidence lacking on the anti-remodeling effects ARBs RIHD, while results clinical studies controversial. We aimed at investigating losartan rat model RIHD. Male...
Despite the effectiveness of doxorubicin (DOXO) as a chemotherapeutic agent, dose-dependent development chronic cardiotoxicity limits its application. The angiotensin-II receptor blocker losartan is commonly used to treat cardiac remodeling various etiologies. beta-3 adrenergic agonist mirabegron was reported improve heart failure. Here we investigated effects losartan, and their combination on DOXO-induced cardiotoxicity. Male Wistar rats were divided into five groups: (i) control; (ii)...