A5043019374- Renal cell carcinoma treatment
- Advanced Radiotherapy Techniques
- Prostate Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Treatment and Research
- Renal and related cancers
- Pelvic floor disorders treatments
- Cardiac Imaging and Diagnostics
- Cancer Genomics and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Urinary Bladder and Prostate Research
- Hungarian Social, Economic and Educational Studies
- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Cancer Immunotherapy and Biomarkers
- Urologic and reproductive health conditions
- Urinary Tract Infections Management
- Effects of Radiation Exposure
- Urinary and Genital Oncology Studies
- Head and Neck Cancer Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Kidney Stones and Urolithiasis Treatments
- Epigenetics and DNA Methylation
University of Szeged
2016-2025
Institute of Materials and Environmental Chemistry
2025
Budapest University of Technology and Economics
2025
Semmelweis University
2009-2024
Buda Health Center
2024
Albstadt-Sigmaringen University
2009-2023
Hungarian Meteorological Service
2023
Szent Imre Egyetemi Oktatókórház
2023
Massachusetts General Hospital
2023
University of Debrecen
2005-2022
Lymphadenectomy for prostate cancer is limited to obturator and external iliac lymph nodes, although the internal nodes represent primary landing zone of lymphatic drainage. We performed anatomically adequate extended pelvic lymphadenectomy assess incidence node metastasis in cases clinically localized cancer.A total 103 consecutive patients underwent at radical retropubic prostatectomy comprising 9 selective fields, namely iliac, common bilaterally, presacral nodes. Histopathological...
Chimeric monoclonal antibody G250 (WX-G250) binds to a cell surface antigen found on >90% of renal carcinoma (RCC). A multicentre phase II study was performed evaluate the safety and efficacy WX-G250 in metastatic RCC (mRCC) patients. In all, 36 patients with mRCC were included. given weekly by intravenous infusion for 12 weeks. Patients stable disease (SD) or response eligible receive additional treatment 8 None enrolled experienced any drug-related grade III IV toxicity. Only three had...
Hedgehog signaling is required for formation and patterning of the anterior pituitary gland. However, role in precursor cell specification subsequent placode not well understood. We analyzed lineages find that pitx3 distal-less3b (dlx3b) expression domains define lens positions. show pre-placode specification, whereas dlx3b dlx4b are to restrict size. In smoothened mutant embryos cannot transduce signals, median precursors mis-specified form an ectopic lens. Moreover, overexpression sonic...
Studying the clinical utility of deep-inspirational breath-hold (DIBH) in left breast cancer radiotherapy (RT) was aimed at focusing on dosimetry and feasibility aspects.In this prospective trial all enrolled patients went through planning CT supine position under both DIBH free breathing (FB); whole irradiation (WBI) cases prone also taken. In 3-dimensional conformal (3DCRT) plans heart, anterior descending coronary artery (LAD), ipsilateral lung contralateral doses were analyzed. The...
The pituitary gland consists of two major parts: the neurohypophysis, which is neural origin; and adenohypophysis, non-neural ectodermal origin. Development adenohypophysis governed by signaling proteins from infundibulum, a ventral structure diencephalon that gives rise to neurohypophysis. In mouse, fibroblast growth factors Fgf8, Fgf10 Fgf18 are thought affect multiple processes development: morphogenesis patterning adenohypophyseal anlage; survival, proliferation differential...
Background High-dose radiation-induced blood-brain barrier breakdown contributes to acute radiation toxicity syndrome and delayed brain injury, but there are few data on the effects of low dose cranial irradiation. Our goal was measure changes after (0.1 Gy), moderate (2 Gy) high (10 irradiation under in vivo vitro conditions. Methodology Cranial performed 10-day-old 10-week-old mice. Blood-brain permeability for Evans blue, body weight number peripheral mononuclear circulating endothelial...
The development of stable biopharmaceutical formulations, such as monoclonal antibodies, poses a great challenge in the pharmaceutical industry. This study investigated stabilizing effect 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) liquid and solid formulations infliximab during processing storage. formulation was produced by scaled-up high-speed electrospinning method, resulting product suitable for reconstitution with excellent dissolution properties. Liquid contained exclusively HP-β-CD...
Severe respiratory failure often requires veno-venous extracorporeal membrane oxygenation (v-v ECMO) treatment, a procedure frequently associated with acute kidney injury (AKI). Preclinical studies have demonstrated the anti-inflammatory properties of inhaled methane (CH4). This experimental protocol aimed to investigate whether CH4 gas administration could mitigate development AKI in clinically relevant large animal model v-v ECMO. Anesthetized miniature pigs were divided into three groups...
Background: A deleterious, late-onset side effect of thoracic radiotherapy is the development radiation-induced heart disease (RIHD). It covers a spectrum cardiac pathology including also failure with preserved ejection fraction (HFpEF) characterized by left ventricular hypertrophy (LVH) and diastolic dysfunction. MicroRNA-212 (miR-212) crucial regulator pathologic LVH via FOXO3-mediated pathways in pressure-overload-induced failure. We aimed to investigate whether miR-212 its selected...
Harninkontinenz ist neben Störungen der erektilen Funktionsfähigkeit die häufigste Funktionseinschränkung nach radikaler Prostatektomie (RPE) beim Prostatakarzinom (PCa). Die deutsche S3-Leitlinie empfiehlt, Patienten über mögliche Auswirkungen Therapieoptionen zu informieren (darunter Inkontinenz). Allerdings liegen bislang nur ungenaue Daten zur Kontinenz aus Routineversorgung im deutschsprachigen Raum RPE vor, was Information erschwert. Ziel dieser Arbeit es, Häufigkeit und Ausprägung...
An objective method for the quantitative measurement of coronary blood flow in ml./min. using a coincidence counting system with rubidium-84, positron emitter, is described. Accidental counts arising from independent annihilation positrons were greatly reduced by simple shielding. The was calculated extrapolation clearance values to zero time. At this time myocardial extraction ratio rubidium-84 unity and equal flow. accuracy demonstrated on isolated perfused dog heart. It found that rate...