A5024227612- Renal Diseases and Glomerulopathies
- Neuroendocrine Tumor Research Advances
- Renal Transplantation Outcomes and Treatments
- Renal and Vascular Pathologies
- Lung Cancer Research Studies
- Systemic Sclerosis and Related Diseases
- Neuroblastoma Research and Treatments
- Renal and related cancers
- Organ Transplantation Techniques and Outcomes
- AI in cancer detection
- Acute Kidney Injury Research
- Systemic Lupus Erythematosus Research
- Cardiac Arrest and Resuscitation
- Protease and Inhibitor Mechanisms
- Pancreatic and Hepatic Oncology Research
- HER2/EGFR in Cancer Research
- Hormonal Regulation and Hypertension
- Peptidase Inhibition and Analysis
- Cell Adhesion Molecules Research
- Blood Pressure and Hypertension Studies
- Pediatric Urology and Nephrology Studies
- Prenatal Screening and Diagnostics
- Pregnancy and Medication Impact
- Autoimmune Bullous Skin Diseases
- Chronic Kidney Disease and Diabetes
University of Szeged
2020-2025
Fibronectin glomerulopathy (FG) is caused by fibronectin 1 (FN1) gene mutations. A renal biopsy was performed on a 4-year-old girl with incidentally discovered proteinuria (150 mg/dL); her family history of disease negative. Markedly enlarged glomeruli (mean glomerular diameter: 196 μm; age-matched controls: 140 μm), α-SMA-positive and Ki-67-positive mesangial cell proliferation (glomerular index 1.76), the mild expansion areas, no immune or electron-dense deposits, normal basement membrane,...
The advent of digital nephropathology offers the potential to integrate deep learning algorithms into diagnostic workflow. We introduce PICASO, a novel permutation-invariant set operator dynamically aggregate histopathologic features from instances. applied PICASO two scenarios: detecting active crescent lesions in sets glomerular crops with IgA nephropathy and case-level classification for antibody-mediated rejection (AMR) kidney transplant. is Transformer-based that aggregates instances...
A primer aldosteronismus a leggyakoribb endokrin hypertoniaforma, az összes eset körülbelül 5-20%-a. Egy fiatal, obes nőbeteget először 2014-ben vizsgáltunk ki rezisztens hypertonia miatt, de akkor szekunder okot nem találtunk elhízáson kívül. 2023-ban vérnyomása megemelkedett, hypokalaemia jelent meg. Spironolaktonra szignifikánsan javult, szérumaldoszteron-koncentráció CT jobb oldali mellékvese-adenomát írt le. 2024 nyarán sikeres laparoszkópos adrenalectomia történt, utána monoterápiával...
Severe respiratory failure often requires veno-venous extracorporeal membrane oxygenation (v-v ECMO) treatment, a procedure frequently associated with acute kidney injury (AKI). Preclinical studies have demonstrated the anti-inflammatory properties of inhaled methane (CH4). This experimental protocol aimed to investigate whether CH4 gas administration could mitigate development AKI in clinically relevant large animal model v-v ECMO. Anesthetized miniature pigs were divided into three groups...
The Oxford Classification for IgA nephropathy is the most successful example of an evidence-based nephropathology classification system. aim our study was to replicate glomerular components scoring with end-to-end deep learning pipeline that involves automatic segmentation followed by mesangial hypercellularity (M), endocapillary (E), segmental sclerosis (S) and active crescents (C).A total number 1056 periodic acid-Schiff (PAS) whole slide images (WSIs), coming from 386 kidney biopsies,...
Pathogenic variants in the FAN1 gene lead to a systemic disease with karyomegalic interstitial nephritis (KIN) at forefront clinically. The phenotypic-genotypic features of mutation-related involving five members Hungarian Caucasian family are presented. Each had adult-onset chronic kidney unknown cause treated renal replacement therapy and elevated liver enzymes. Short stature, emaciation, latte-colored skin, freckles, hawk-like nose four patients, limited intellect two restrictive lung one...
ABSTRACT Background The decision to accept or discard the increasingly rare and marginal brain-dead donor kidneys in Eurotransplant (ET) countries has be made without solid evidence. Thus, we developed validated flexible clinicopathological scores called 2-Step Scores for prognosis of delayed graft function (DGF) 1-year death-censored transplant loss (1y-tl) reflecting current practice six ET including Croatia Belgium. Methods training set was n = 620 DGF 711 1y-tl, with validation sets 158...
Considering the specific clinical management of neuroendocrine (NE) neoplasms (NENs), immunohistochemistry (IHC) is required to confirm their diagnosis. Nowadays, synaptophysin (SYP), chromogranin A (CHGA), and CD56 are most frequently used NE immunohistochemical markers; however, sensitivity specificity less than optimal. Syntaxin 1 (STX1) a member membrane-integrated protein family involved in neuromediator release, its expression has been reported be restricted neuronal tissues. In this...
Introduction: A subset of breast neoplasia is characterized by features neuroendocrine differentiation. Positivity for Neuroendocrine markers immunohistochemistry required the diagnosis. Sensitivity and specificity currently used are limited; based on definitions WHO Classification Tumours, 5th edition, about 50% tumors with differentiation express chromogranin-A 16% synaptophysin. We assessed applicability two novel markers, syntaxin-1 insulinoma-associated protein 1 (INSM1) in carcinomas....
Abstract Background The diagnostic performance of PLA2R and IgG subclass staining kidney biopsies relative to anti-PLA2R seropositivity in the differentiation primary secondary membranous nephropathy (pMN, sMN) was examined. Besides – which has a lower specificity than antibody serology there is insufficient knowledge decide IgG1-4 subtype immunohistological patterns (IgG4-dominance, IgG4-dominance/IgG1-IgG4-codominance or IgG4-dominance/IgG4-codominance with any subtype) could be used...
Syntaxin‐1 (STX1) is a recently described highly sensitive and specific neuroendocrine marker. We evaluated the applicability of STX1 as an immunohistochemical marker in pulmonary neoplasms (NENs). compared with established markers, including insulinoma‐associated protein 1 (INSM1). Typical carcinoids (n = 33), atypical 7), small cell lung carcinomas ([SCLCs] n 30), large 17) were immunostained using tissue microarray for STX1, chromogranin A, synaptophysin, CD56, INSM1. Eighty‐four...
This study highlights the importance of a combined diagnostic approach in diagnosis rare diseases, such as adult-onset genetic FSGS. We present three adult patient cases evaluated with kidney biopsy for proteinuria, chronic disease, and hypertension, which were suggestive Renal samples formalin-fixed, paraffin-embedded fetal kidneys using standard light microscopical stainings, direct immunofluorescence on cryostat sections, electron microscopy. Clinical exome sequencing was performed each...
Veno-venous extracorporeal membrane oxygenation (vv-ECMO) can save lives in severe respiratory distress, but this innovative approach has serious side-effects and is accompanied by higher rates of iatrogenic morbidity. Our aims were, first, to establish a large animal model vv-ECMO study the pathomechanism complications within clinically relevant time frame and, second, investigate renal reactions increase likelihood identifying novel targets improve clinical outcomes vv-ECMO-induced acute...
Oligomeganephronic hypoplasia, commonly referred to as oligomeganephronia (OMN), is a rare pediatric disorder characterized by small kidneys. Histologically paucity of nephrons observed which show compensatory enlargement. Hyperfiltration injury leads end-stage kidney disease. Here we report 23-year-old Caucasian female patient who presented with 7-year history nonnephrotic proteinuria, slow worsening renal function, normal-sized kidneys, normal blood pressure, healthy weight, and...
Death with a functioning graft and death-censored renal allograft failure remain major problems for which effective preventative protocols are lacking. The retrospective cohort study aimed to determine whether histologic changes on 5-year surveillance kidney biopsy predict adverse outcomes after transplantation in recipients who had: both Type 2 diabetes (T2DM) obesity (BMI ≥ 30 kg/m2 ) at the time of (T2DM/Obesity, n = 75); neither (No T2DM/No obesity, 78); No T2DM/Obesity (n 41), 47). On...
Abstract Background and Aims Diagnostic applications of machine learning in nephropathology are only beginning to emerge. We hypothesized that we could develop a classifier for 12 different classes glomerulonephritis with CNN self-attention-based architectures, following the paradigm globally sclerosed glomeruli not useful diagnostic purposes. Method The dataset contains 11,000 PAS-stained glomerular crops from 350 biopsies (four institutions). Each crop retained diagnosis label ABMGN, ANCA,...
Background. Mesangial expansion (ME) is an understudied histologic lesion in renal allografts. The current Banff mm score not reproducible and may miss important ME features. study aimed to improve the quantification of using morphometry, assess changes over time, determine its association with allograft loss. Methods. We studied 1-y 5-y surveillance biopsies 835 kidney transplants performed between January 2000 December 2013. was assessed by a central pathologist morphometry. derived 3...
Histologic findings on 1-year biopsies such as inflammation with fibrosis and transplant glomerulopathy predict renal allograft loss by 5 years. However, almost half of the patients graft have a biopsy that is either normal or has only interstitial fibrosis. The goal this study was to determine if there gene expression profile in these relatively predicted subsequent decline function. Using transcriptome microarrays we measured intragraft mRNA levels retrospective Discovery cohort (170...
Abstract Background and Aims Machine learning (ML) holds great promise for improving diagnostics, prognostication theranostics in nephropathology. So far, applications have not gone much further than segmentation of tissue compartments on whole slide images (WSIs) paraffin sections. As a proof-of-concept study, we describe the development diagnostic classifier glomerulephritis based expert-annotated or automatically segmented glomerular transections from periodic-acid Schiff (PAS) sections...
Adenocarcinomas and noninvasive intraepithelial neoplasms (either polypoid or flat) are the most common gallbladder tumors; however, neuroendocrine (NENs) can also occur. The majority of NENs represented by carcinomas (NECs), while tumors (NETs) extremely rare in this location. Occasionally, NEN may present as a part mixed neoplasm, with coexisting non-neuroendocrine component. latest World Health Organization classification denotes these lesions neuroendocrine–non-NENs (MiNENs). A novel...