A5018450987- Renal cell carcinoma treatment
- Renal and related cancers
- Cancer Genomics and Diagnostics
- Sports Performance and Training
- Bladder and Urothelial Cancer Treatments
- Renal Transplantation Outcomes and Treatments
- Cancer Immunotherapy and Biomarkers
- Cardiovascular and exercise physiology
- High Altitude and Hypoxia
- Pancreatic and Hepatic Oncology Research
- Tuberous Sclerosis Complex Research
- Winter Sports Injuries and Performance
- Osteoarthritis Treatment and Mechanisms
- biodegradable polymer synthesis and properties
- Sports injuries and prevention
- Muscle metabolism and nutrition
- Medical and Health Sciences Research
- Parathyroid Disorders and Treatments
- Organ Donation and Transplantation
- Microplastics and Plastic Pollution
- Economic and Financial Impacts of Cancer
- Prostate Cancer Treatment and Research
- Urinary Tract Infections Management
- Prostate Cancer Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
Swiss Federal Institute of Sport Magglingen SFISM
2014-2025
Helios Klinikum Erfurt
2013-2024
University of Bayreuth
2020-2024
Semmelweis University
2024
Institute for Biomedical Engineering
2012-2021
ETH Zurich
2008-2021
Arbeitsgemeinschaft Urologische Onkologie
2017-2021
German Cancer Society
2017-2021
Committee on Publication Ethics
2018
Saarland University
2018
This study aims to investigate physical performance and hematological changes in 32 elite male team-sport players after 14 d of "live high-train low" (LHTL) training normobaric hypoxia (≥14 h·d at 2800-3000 m) combined with repeated-sprint (six sessions four sets 5 × 5-s sprints 25 s passive recovery) either 3000 m (LHTL + RSH, namely, LHTLH; n = 11) or normoxia RSN, LHTL; 12) compared controlled low-train (LLTL; 9) training.Before (Pre), immediately (Post-1), 3 wk (Post-2) the intervention,...
Abstract Research on the plastic contamination of organic fertilizer (compost) has largely concentrated particles and fragments > 1 mm. Small, submillimeter microplastic may be more hazardous to environment. However, research their presence in composts been impeded by difficulty univocally identify small such complex matrices. Here a method is proposed for analysis between 0.01 1.0 mm according number, size, polymer type compost. As first demonstration its potential, used determine large...
Abstract The aim of this study was to compare the accuracy among a high number current mobile cycling power meters used by elite and recreational cyclists against first principle-based mathematical model treadmill cycling. 54 from 9 manufacturers 32 were calibrated. While cyclist coasted downhill on motorised treadmill, back-pulling system adjusted counter force. then loaded 3 times with 4 different masses while pedalled keep his position. mean deviation (trueness) coefficient variation...
Abstract Biodegradable plastics (BDP) are expected to mineralize easily, in particular under conditions of technical composting. However, the complexity sample matrix has largely prevented degradation studies realistic conditions. Here composts and fertilizers from state-of-the-art municipal combined anaerobic/aerobic biowaste treatment plants were investigated for residues BDP. We found BDP fragments > 1 mm significant numbers final intended as fertilizer agriculture gardening. Compared...
Introduction Elite cross-country (XC) skiers undergo standardized testing to monitor their performance development and calibrate training prescriptions. However, the long-term progression of indicators, such as maximal oxygen uptake (VO2max), at second lactate threshold (LT2), time-trial over an athlete's career remains unclear. This study aimed investigate longitudinal data from > 15 years exercise with Swiss XC ski national team examine trajectories key indicators across careers male...
The purpose of this research was to compare individual hemoglobin mass (Hb ) changes following a live high-train low (LHTL) altitude training camp under either normobaric hypoxia (NH) or hypobaric (HH) conditions in endurance athletes. In crossover design with one-year washout, 15 male triathletes randomly performed two 18-day LHTL camps HH NH. All athletes slept at 2,250 meters and trained altitudes <1,200 meters. Hb measured duplicate the optimized carbon monoxide rebreathing method...
It is unclear if hemoglobin mass (Hbmass) and red cell volume (RCV) increase in endurance athletes with several years of training from adolescence to adulthood. The aim this study, therefore, was determine a controlled cross-sectional approach whether at the ages 16, 21, 28 yr are characterized by different Hbmass, RCV, plasma (PV), blood (BV).BV parameters (CO rebreathing), VO(2max) other blood, iron, training, anthropometric were measured three athlete groups AG16 (n = 14), AG21 AG28 16)...
To give an overview of the multicenter Prostate Cancer Outcomes (PCO) study, involving paper-based and web-based collection patient-reported outcome measures (PROM) in patients undergoing local treatment for prostate cancer certified centers Germany. The PCO study is part larger Movember-funded TrueNTH Global Registry. article reports on study's design provides a brief progress report after first 2 years data collection.Prostate (PCCs) according to German Society requirements were invited...
Abstract High-caloric-value household biowaste is an attractive substrate for the production of biogas and fertilizer. Most contaminated by plastics, typically in form bags foils from packaging. Operators municipal treatment plans take great care to remove these contaminants, often at cost reducing organic material entering process. This study compares residual plastic contamination fertilizer (composts, digestates) plants with compost produced greenery digestates agricultural processing...
Harninkontinenz ist neben Störungen der erektilen Funktionsfähigkeit die häufigste Funktionseinschränkung nach radikaler Prostatektomie (RPE) beim Prostatakarzinom (PCa). Die deutsche S3-Leitlinie empfiehlt, Patienten über mögliche Auswirkungen Therapieoptionen zu informieren (darunter Inkontinenz). Allerdings liegen bislang nur ungenaue Daten zur Kontinenz aus Routineversorgung im deutschsprachigen Raum RPE vor, was Information erschwert. Ziel dieser Arbeit es, Häufigkeit und Ausprägung...
We investigated the immunomodulatory capacity of primary cultures renal cell carcinomas (RCC) by assessing production cytokines and modulation mitogen-induced T lymphocyte blast transformation. The results clearly show that is a common feature RCC in vitro these tumors can produce interleukin-10 (IL-10) up to 20 ng/ml, IL-6 35 μg/ml (>250 kU/ml B9 system), IL-11 15 μg/ml, transforming growth factor-β1 (TGF-β1) 22 ng/ml. Furthermore, have modulate transformation over two orders magnitude each...
The discovery of metastasis markers in clear cell renal carcinoma is critical importance to define individual metastatic risk and select patients for new targeted therapies. We identified potential biomarkers by gene expression analysis.We performed transcriptional profiling 16 primary 18 nonmetastatic carcinomas with PIQOR™ microarrays. Differentially expressed genes were validated quantitative real-time polymerase chain reaction.Genes discriminating between tumors at q <0.001 significance...
It is unknown, whether endurance training stimulates hemoglobin mass (Hbmass) and maximal oxygen uptake (V˙O2max) increases during late adolescence. Therefore, this study assessed the influence of on Hbmass, blood volume parameters, V˙O2max in athletes control subjects from age 16 to 19 yr.Hemoglobin mass, anthropometric parameters were measured male elite yr 6-month intervals (n = 10), as well age-matched controls 12).Neither level Hbmass per lean body (LBM) (P 0.80) nor development 3 0.97)...
Compared with non-diabetic subjects, patients type 2 diabetes and end-stage renal disease (ESRD) have seldom been selected for transplantation. It was the aim of this study to compare long-term prognoses two groups after transplantation identify factors associated allograft rejection.In a retrospective analysis, we studied all 333 consecutive who received kidney transplant at our centre since 1992. Mean follow-up in 302 out (91%) 3.3+/-1.5 (0.1-11.7) years. At time transplantation, mellitus...
The main aim of the present study was to quantify magnitude differences introduced when estimating a given blood volume compartment (e.g. plasma volume) through direct determination another red cell by multiplication venous haematocrit and/or haemoglobin concentration. However, since whole body is higher than such an approach might comprise certain errors. To test this experimentally, four different methods for detecting volumes and mass (Hbmass) were compared, namely carbon monoxide (CO)...
Abstract Cross-country (XC) ski races involve a variety of formats, two different techniques and tracks with highly variable topography environmental conditions. In addition, XC skiing is major component both Nordic combined biathlon competitions. Research in this area, the laboratory field, encounters certain difficulties that may reduce reliability validity data obtained, as well complicate comparisons between studies. Here, 13 international experts propose specific guidelines designed to...
Abstract Background Microplastics (MP, plastic particles <5 mm) are ubiquitous in arable soils due to significant inputs via organic fertilizers, sewage sludges, and mulches. However, knowledge of typical MP loadings, their fate, ecological impacts on is limited. Aims We studied (1) background concentrations, (2) the fate added conventional biodegradable MP, (3) effects combination with fertilizers microbial abundance activity associated carbon (C) cycling, crop yields an soil. Methods On...