A5102812593- Clinical Laboratory Practices and Quality Control
- Acute Myeloid Leukemia Research
- Renal function and acid-base balance
- Meta-analysis and systematic reviews
- Renal cell carcinoma treatment
- Iron Metabolism and Disorders
- Pancreatic and Hepatic Oncology Research
- Financial Reporting and Valuation Research
- Risk Management in Financial Firms
- Healthcare cost, quality, practices
- Hemodynamic Monitoring and Therapy
- Folate and B Vitamins Research
- Drug Transport and Resistance Mechanisms
- Health and Medical Research Impacts
- Cancer Immunotherapy and Biomarkers
- Neonatal Health and Biochemistry
- Hematological disorders and diagnostics
- Neonatal Respiratory Health Research
- Neutropenia and Cancer Infections
- Pregnancy and Medication Impact
- Insurance and Financial Risk Management
- Metabolism and Genetic Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Sepsis Diagnosis and Treatment
- Statistical Methods in Clinical Trials
South Australia Pathology
2010-2024
Praxis für Hämatologie und Onkologie
2020-2023
Women's and Children's Hospital
2010-2019
The University of Adelaide
2014-2018
Capgemini (Netherlands)
2018
Women's and Children's Health Network
2017
Royal College of Pathologists of Australasia
2017
Finnish Institute for Health and Welfare
2015
New York University Press
2015
Cambridge University Press
2015
The multicenter, randomized, phase IV, intergroup AGO-B WSG PreCycle trial (NCT03220178) evaluated the impact of CANKADO-based electronic patient-reported outcome (ePRO) assessment on quality life (QoL) in hormone receptor-positive, human epidermal growth factor receptor 2-negative locally advanced or metastatic breast cancer (MBC) patients receiving palbociclib and an aromatase inhibitor + fulvestrant. CANKADO PRO-React, a European Union-registered medical device, is interactive autonomous...
Background: Rabeprazole has a faster onset of antisecretory action than omeprazole, and it is interest to determine whether this translates into symptom relief in patients with gastro‐oesophageal reflux disease. Aims: To assess the from heartburn after 3 days treatment standard‐dose rabeprazole or high‐dose omeprazole (primary end‐point). Secondary end‐points included decrease score for other symptoms disease, healing rates quantification antacid use. Methods: Patients endoscopically...
Pediatric within-individual biological variation (CVi) is a challenge to derive by direct sampling due clinical, logistical, and ethical barriers.Laboratory results of 22 basic biochemistry tests performed on 9,356 children who visited primary care physicians more than once over year were obtained from large laboratory network in Australia. The CVi calculated as (CVT (2) - CVa (2))(0.5), where CVT was the coefficient between repeat measurements analytical imprecision. Smoothed 50th centile...
Derivation of between-individual biological variation (CVg) data requires repeat sampling the same subject, which is undesirable and challenging in children. We describe an indirect (data mining) approach to obtain these children.Twenty-two serum biochemistry results from 6,989 children, who visited their primary care physician Queensland, Australia, were tested only twice within a year included. The CVg index individuality boys girls estimated by age, according procedures recommended Fraser...
The purpose of this study was to determine a cut-off above which result is considered abnormal for 'spot' calcium-to-creatinine ratio (Ca/Cr) in urine the paediatric age group. While cut-offs are not well established, there many published reports Ca/Cr excretion literature. Rather than undertaking difficult, time-consuming, expensive, and ultimately redundant study, an analysis these works undertaken laboratory.Fourteen studies reporting available literature were reviewed. Each abstracted...
Aims To describe the reference intervals and biological variation data for thyrotropin (TSH) free thyroxine (FT4) in a mixed Asian population using an indirect sampling approach to compare them with published reports. Methods TSH FT4 of children measured once or twice over 7-year period (2008–2014) at primary-care tertiary-care settings were extracted from laboratory information system. After excluding outliers, age-related derived Lambda-Mu-Sigma (LMS) approach, while age-partitioned...
There is currently a lack of an outcomes-based definition critical values for the pediatric population. This has contributed to highly heterogeneous value reporting practice between laboratories.Anonymized results were extracted from laboratory information system 10 biochemistry tests. The probability high-dependency/intensive care unit admission (as proxy adverse outcomes) each individual concentration was calculated and adjusted fit using polynomial function model trend. that intersected...
To derive outcome-based critical result thresholds in the adult patient population.We extracted deidentified laboratory results and outcomes (death or discharged) of patients 18 years older from Medical Information Mart for Intensive Care database. The lower upper were obtained nearest minimum maximum values, which corresponded to predicted probability death at 90%.The value sodium (<123, >153 mmol/L), potassium (<2.2, >6.6 bicarbonate (<15, >49 chloride (<82, >121 urea (>20 creatinine...
This multicenter open-label clinical trial was designed to investigate the safety and efficacy of donepezil, a selective acetylcholinesterase inhibitor, in treatment Alzheimer’s disease (AD) routine practice Germany. A total 237 patients with mild-to-moderate AD were treated donepezil for 24 weeks, 186 completed study according protocol. In completer group, mean MMSE score showed an improvement from baseline +1.6 points at week 12 (95% CI +1.1 +2.1) +0.5 +1.7). more than 80% patients, global...
[Extract] It's not as simple new for old: we need to follow a process “disinvestment” in existing medical procedures, services and technologies Criteria have been developed assessing the safety, effectiveness cost‐effectiveness of emerging health interventions, but additional challenges exist identifying opportunities reducing use technologies or procedures that are potentially overused, (cost‐)ineffective unsafe.1 Criteria proposed flag might warrant further investigation under quality...
Objective: To determine the biochemical screening rate of newborns in South Australia and factors associated with babies not being screened. Design: Matching data SA Newborn Screening Centre database (acquired from Guthrie cards) perinatal collection (compiled supplementary birth records) to how many missed screening. Risk for were identified sociodemographic clinical variables recorded analysed by multivariable unconditional logistic regression analysis. Patients setting: All live births (n...
We determined the relative strengths of association between 23 most commonly ordered laboratory tests and adverse outcome as indicators criticalness. The lowest highest results for tests, 24 hours prior to death during critical care unit (CCU) stay or discharge from CCU were extracted a publicly available database (Medical Information Mart Intensive Care-III). Following this, Random Forest model was applied assess outcomes (death discharge). mean decrease in Gini coefficient each test then...